SUPER-RESOLUTION OPTICAL MICROSCOPY USING ALUMINOSILICATE NANOPARTICLES

    公开(公告)号:US20220113315A1

    公开(公告)日:2022-04-14

    申请号:US17501854

    申请日:2021-10-14

    IPC分类号: G01N33/58 G01N21/64 A61K49/00

    摘要: Methods of obtaining and kits that can be used to obtain an optical super-resolution image of a sample or a portion thereof or an individual or a portion thereof. In various examples, the individual is an individual with cancer. In various examples, a method includes contacting a sample or individual with one or more aluminosilicate nanoparticle(s) that have at least one organic fluorophore molecule covalently bonded to the aluminosilicate network of the nanoparticle(s), or a composition including the aluminosilicate nanoparticle(s); irradiating the sample or the individual, thereby exciting at least one of the fluorophore molecules of an individual aluminosilicate nanoparticle; and obtaining a fluorescence image or a sequence of fluorescence images, which can be processed to obtain a super-resolution image of the sample or the individual. In various examples, the sample is a biological sample, living or fixed tissues and/or cells, or a biopsy obtained from an individual.

    FILMS DERIVED FROM TWO OR MORE CHEMICALLY DISTINCT BLOCK COPOLYMERS, METHODS OF MAKING SAME, AND USES THEREOF

    公开(公告)号:US20200216618A1

    公开(公告)日:2020-07-09

    申请号:US16813444

    申请日:2020-03-09

    摘要: Methods of making blended, isoporous, asymmetric (graded) films (e.g. ultrafiltration membranes) comprising two or more chemically distinct block copolymers and blended, isoporous, asymmetric (graded) films (e.g. ultrafiltration membranes) comprising two or more chemically distinct block copolymers. The generation of blended membranes by mixing two chemically distinct block copolymers in the casting solution demonstrates a pathway to advanced asymmetric block copolymer derived films, which can be used as ultrafiltration membranes, in which different pore surface chemistries and associated functionalities can be integrated into a single membrane via standard membrane fabrication, i.e. without requiring laborious post-fabrication modification steps. The block copolymers may be diblock, triblock and/or multiblock mixes and some block copolymers in the mix may be functionally modified. Triblock copolymers comprising a reactive group (e.g., sulfhydryl group) terminated block and films comprising the triblock copolymers.

    Functionalized nanoparticles and methods of making and using same

    公开(公告)号:US11419952B2

    公开(公告)日:2022-08-23

    申请号:US16614975

    申请日:2018-05-21

    摘要: Described is a versatile surface modification approach to, for example, modularly and orthogonally functionalize nanoparticles (NPs) such as, for example, PEGylated nanoparticles, ith various types of different functional ligands (functional groups) on the NP surface. It enables the synthesis of, for example, penta-functional PEGylated nanoparticles integrating a variety of properties into a single NP, e.g., fluorescence detection, specific cell targeting, radioisotope chelating/labeling, ratiometric pH sensing, and drug delivery, while the overall NP size remains, for example, below 10 nm.

    CRYSTALLINE ORGANIC-INORGANIC HALIDE PEROVSKITE THIN FILMS AND METHODS OF PREPARATION
    10.
    发明申请
    CRYSTALLINE ORGANIC-INORGANIC HALIDE PEROVSKITE THIN FILMS AND METHODS OF PREPARATION 有权
    晶体有机无机材料薄膜薄膜及其制备方法

    公开(公告)号:US20160251303A1

    公开(公告)日:2016-09-01

    申请号:US15054988

    申请日:2016-02-26

    IPC分类号: C07C211/63 B05D3/00

    摘要: A film comprising a crystalline halide perovskite composition having the following formula: AMX3   (1) wherein: A is an organic cation selected from the group consisting of methylammonium, tetramethylammonium, formamidinium, and guanidinium; M is at least one divalent metal; and X is independently selected from halide atoms; wherein the crystalline film of the halide perovskite composition possesses at least one of an average grain size of at least 30 microns, substantial crystal orientation evidenced in an ordering parameter of at least 0.6, and a level of crystallinity of at least 90%. Methods for producing films of these halide perovskite compositions using ionic liquids instead of volatile organic solvents are also described herein.

    摘要翻译: 一种包含具有下式的结晶卤化物钙钛矿组合物的膜:AMX3(1)其中:A是选自甲基铵,四甲基铵,甲脒和胍的有机阳离子; M是至少一种二价金属; 并且X独立地选自卤素原子; 其中所述卤化钙钙钛矿组合物的结晶膜具有至少30微米的平均晶粒尺寸,在至少0.6的有序参数中证实的显着晶体取向和至少90%的结晶度水平中的至少一种。 本文还描述了使用离子液体代替挥发性有机溶剂来生产这些卤化钙钙钛矿组合物的膜的方法。