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    CELL CULTURE SUBSTRATE HAVING UNIFORM SURFACE COATING
    1.
    发明申请
    CELL CULTURE SUBSTRATE HAVING UNIFORM SURFACE COATING 审中-公开
    具有均匀表面涂层的细胞培养基底

    公开(公告)号：US20140141503A1

    公开(公告)日：2014-05-22

    申请号：US13892697

    申请日：2013-05-13

    Applicant: Corning Incorporated

    Inventor： Yulong Hong ,  Jennifer Lynn Hunt ,  Meenal Pauddar Soni ,  Hui Su ,  Jian Tan

    IPC: C12M1/00

    CPC classification number: C12M23/34 ,  C12M23/10 ,  C12M23/20

    Abstract: An article for culturing cells includes (i) a substrate having a surface; (ii) a plurality of pillars extending from the surface of the substrate; and (iii) a polymeric coating disposed on the surface of the substrate between the pillars, forming a plurality of mini-menisci on the surface of the substrate between the plurality of pillars. The mini-menisci may have diameters of from about 20 to about 250 micrometers. The plurality of pillars are spaced apart from one another in a manner to encourage cell growth on the mini-menisci rather than the on top of the pillars. Such articles may effectively address issues associated with the meniscus effect on a global scale.

    Abstract translation: 用于培养细胞的制品包括（i）具有表面的基材; （ii）从所述基板的表面延伸的多个支柱; 和（iii）在所述支柱之间设置在所述基板的表面上的聚合物涂层，在所述多个支柱之间的所述基板的表面上形成多个微型半月板。 微型半月板可以具有约20至约250微米的直径。 多个支柱以鼓励小型半月板而不是在柱顶上的细胞生长的方式彼此间隔开。 这样的文章可以在全球范围内有效地解决与半月板效应相关的问题。

    Glass-based articles with stress profiles having regions of enhanced stress
    2.
    发明授权
    Glass-based articles with stress profiles having regions of enhanced stress 有权

    公开(公告)号：US12240780B2

    公开(公告)日：2025-03-04

    申请号：US17623791

    申请日：2020-07-01

    Applicant: CORNING INCORPORATED

    Inventor： Jennifer Lynn Hunt ,  Rostislav Vatchev Roussev

    IPC: C03C17/02 ,  C03C3/085 ,  C03C21/00

    Abstract: Glass-based articles comprise: a lithium-based aluminosilicate composition; a glass-based substrate having opposing first and second surfaces defining a substrate thickness (t), wherein t is less than or equal to 0.74 mm; and a stress profile comprising: a spike region extending from the first surface to a tail region. A stress profile comprises: a maximum compressive stress (CSmax) of greater than or equal to 450 MPa; a spike region extending from the first surface to a tail region; and the tail region extending to a center of the glass-based article; wherein the tail region comprises: a region of enhanced stress having a first average compressive stress (CSavg−1) of greater than or equal to 100 MPa; and a FSM depth of layer (DOLFSM) located at a depth of greater than or equal to 13 micrometers.

    GLASS-BASED ARTICLES WITH STRESS PROFILES HAVING REGIONS OF ENHANCED STRESS
    6.
    发明申请
    GLASS-BASED ARTICLES WITH STRESS PROFILES HAVING REGIONS OF ENHANCED STRESS 有权

    公开(公告)号：US20220242780A1

    公开(公告)日：2022-08-04

    申请号：US17623791

    申请日：2020-07-01

    Applicant: CORNING INCORPORATED

    Inventor： Jennifer Lynn Hunt ,  Rostislav Vatchev Roussev

    IPC: C03C17/02 ,  C03C21/00 ,  C03C3/085

    Abstract: Glass-based articles comprise: a lithium-based aluminosilicate composition; a glass-based substrate having opposing first and second surfaces defining a substrate thickness (t), wherein t is less than or equal to 0.74 mm; and a stress profile comprising: a spike region extending from the first surface to a tail region. A stress profile comprises: a maximum compressive stress (CSmax) of greater than or equal to 450 MPa; a spike region extending from the first surface to a tail region; and the tail region extending to a center of the glass-based article; wherein the tail region comprises: a region of enhanced stress having a first average compressive stress (CSavg−1) of greater than or equal to 100 MPa; and a FSM depth of layer (DOLFSM) located at a depth of greater than or equal to 13 micrometers.

    Tempered and colorless antimicrobial soda lime glass and methods of making and using same
    7.
    发明授权
    Tempered and colorless antimicrobial soda lime glass and methods of making and using same 有权

    公开(公告)号：US10723652B2

    公开(公告)日：2020-07-28

    申请号：US15324173

    申请日：2015-07-06

    Applicant: CORNING INCORPORATED

    Inventor： Hongmei Hu ,  Jennifer Lynn Hunt ,  Sumalee Likitvanichkul ,  Ananthanarayanan Subramanian ,  Li Yao

    IPC: C03C21/00 ,  C03C15/00 ,  C03C3/087 ,  A01N25/08 ,  A01N59/16 ,  C03C3/04 ,  C03C4/18

    Abstract: Described herein are various antimicrobial soda lime glass articles that have improved resistance to discoloration when exposed to harsh conditions, including manufacturing conditions. The improved antimicrobial glass articles described herein generally include a SLG substrate that has a thickness, t; a compressive stress layer of about 0.15*t or greater; and an antimicrobial agent-containing region having an antimicrobial agent and a thickness less than the thickness of the compressive stress layer. Roughly 2 to 20 microns of the primary surfaces of the glass substrate can be removed prior to development of the compressive stress and antimicrobial agent-containing region. In some aspects, prior-annealed and tempered, or prior-annealed, SLG is employed as the substrate. In some aspects, the substrate includes tin at one surface. The improved SLG substrates experience substantially no discoloration when exposed to harsh conditions. Methods of making and using the glass articles are also described.

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