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公开(公告)号:US11059786B2
公开(公告)日:2021-07-13
申请号:US16678700
申请日:2019-11-08
申请人: Cortexyme, Inc.
IPC分类号: C07D213/73 , C07D217/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D413/12 , C07D491/048 , A61P25/28
摘要: The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I and Formula III, as described herein, and pharmaceutically acceptable salts thereof.
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公开(公告)号:US11325884B2
公开(公告)日:2022-05-10
申请号:US16899376
申请日:2020-06-11
申请人: CORTEXYME, INC.
发明人: Andrei W. Konradi , Robert A. Galemmo, Jr. , Stephen S. Dominy , Casey C. Lynch , Leslie J. Holsinger
IPC分类号: C07C233/62 , C07D213/82 , C07D239/34 , C07D239/36 , C07D413/12 , C07D257/04 , C07D261/12 , C07D213/70 , C07C317/28 , C07C233/78 , C07C235/10 , C07C235/50 , C07B59/00 , C07C237/42 , C07D401/12 , C07C381/00 , C07C323/42 , C07D213/65 , C07D213/68 , C07D239/38 , C07C247/18 , C07F5/02 , A61P31/04 , A61P25/00 , A61K31/165 , A61K31/167 , A61K31/41 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/505 , A61K31/513 , A61K31/655 , A61K45/06 , C07C245/08 , C07C247/16 , C07C323/40 , C07D213/81
摘要: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
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公开(公告)号:US10730826B2
公开(公告)日:2020-08-04
申请号:US16353786
申请日:2019-03-14
申请人: CORTEXYME, INC.
发明人: Andrei W. Konradi , Robert A. Galemmo, Jr. , Stephen S. Dominy , Casey C. Lynch , Leslie J. Holsinger
IPC分类号: C07C233/62 , C07D213/82 , C07D239/34 , C07D239/36 , C07D413/12 , C07D257/04 , C07D261/12 , C07D213/70 , C07C317/28 , C07C233/78 , C07C235/10 , C07C235/50 , C07B59/00 , C07C237/42 , C07D401/12 , C07C381/00 , C07C323/42 , C07D213/65 , C07D213/68 , C07D239/38 , C07C247/18 , C07F5/02 , A61P31/04 , A61P25/00 , A61K31/165 , A61K31/167 , A61K31/41 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/505 , A61K31/513 , A61K31/655 , A61K45/06 , C07C245/08 , C07C247/16 , C07C323/40 , C07D213/81
摘要: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
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