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公开(公告)号：US20210355527A1
公开(公告)日：2021-11-18
申请号：US17280729
申请日：2019-09-27
Applicant: Cortexyme, Inc.
Inventor： Debasish Raha , Leslie J. Holsinger , Stephen S. Dominy , Casey C. Lynch
Abstract: Methods for detecting microbial nucleic acids in a body fluid of a subject are provided. The methods include highly sensitive and specific procedures for detecting DNA derived from the bacteria such as Porphyromonas gingivalis, e.g., using PCR amplification and qPCR detection, in clinical and/or laboratory samples containing CSF or other biofluids.
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公开(公告)号：US20190210960A1
公开(公告)日：2019-07-11
申请号：US16353786
申请日：2019-03-14
Applicant: CORTEXYME, INC.
Inventor： Andrei W. Konradi , Robert A. Galemmo, JR. , Stephen S. Dominy , Casey C. Lynch , Leslie J. Holsinger
IPC: C07C233/62 , A61K45/06 , A61K31/165 , C07C233/78 , A61K31/167 , C07C247/16 , A61K31/655 , C07D257/04 , A61K31/41 , C07C323/40 , C07C317/28 , C07C235/50 , C07D213/81 , A61K31/44 , C07D213/82 , C07D239/36 , A61K31/513 , A61K31/4406 , C07C245/08 , C07C235/10 , C07D261/12 , A61K31/42 , A61K31/4402 , A61K31/4409 , C07D413/12 , A61K31/4439 , C07D239/34 , A61K31/505 , C07D213/70 , A61P31/04 , A61P25/00
Abstract: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
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Patent Agency Ranking
公开(公告)号：US20210053908A1
公开(公告)日：2021-02-25
申请号：US16899376
申请日：2020-06-11
Applicant: CORTEXYME, INC.
Inventor： Andrei W. Konradi , Robert A. Galemmo, JR. , Stephen S. Dominy , Casey C. Lynch , Leslie J. Holsinger
IPC: C07C233/62 , C07D213/82 , C07D239/34 , C07D239/36 , C07D413/12 , C07D257/04 , C07D261/12 , C07D213/70 , C07C317/28 , C07C233/78 , C07C235/10 , C07C235/50 , C07B59/00 , C07C237/42 , C07D401/12 , C07C381/00 , C07C323/42 , C07D213/65 , C07D213/68 , C07D239/38 , C07C247/18 , C07F5/02 , A61P31/04 , A61P25/00 , A61K31/165 , A61K31/167 , A61K31/41 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/505 , A61K31/513 , A61K31/655 , A61K45/06 , C07C245/08 , C07C247/16 , C07C323/40 , C07D213/81
Abstract: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
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公开(公告)号：US10730826B2
公开(公告)日：2020-08-04
申请号：US16353786
申请日：2019-03-14
Applicant: CORTEXYME, INC.
Inventor： Andrei W. Konradi , Robert A. Galemmo, Jr. , Stephen S. Dominy , Casey C. Lynch , Leslie J. Holsinger
IPC: C07C233/62 , C07D213/82 , C07D239/34 , C07D239/36 , C07D413/12 , C07D257/04 , C07D261/12 , C07D213/70 , C07C317/28 , C07C233/78 , C07C235/10 , C07C235/50 , C07B59/00 , C07C237/42 , C07D401/12 , C07C381/00 , C07C323/42 , C07D213/65 , C07D213/68 , C07D239/38 , C07C247/18 , C07F5/02 , A61P31/04 , A61P25/00 , A61K31/165 , A61K31/167 , A61K31/41 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/505 , A61K31/513 , A61K31/655 , A61K45/06 , C07C245/08 , C07C247/16 , C07C323/40 , C07D213/81
Abstract: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
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公开(公告)号：US12110263B2
公开(公告)日：2024-10-08
申请号：US17740260
申请日：2022-05-09
Applicant: CORTEXYME, INC.
Inventor： Andrei W. Konradi , Robert A. Galemmo, Jr. , Stephen S. Dominy , Casey C. Lynch , Leslie J. Holsinger
IPC: C07C233/62 , A61K31/165 , A61K31/167 , A61K31/41 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/505 , A61K31/513 , A61K31/655 , A61K45/06 , A61P25/00 , A61P31/04 , C07B59/00 , C07C233/78 , C07C235/10 , C07C235/50 , C07C237/42 , C07C245/08 , C07C247/16 , C07C247/18 , C07C317/28 , C07C323/40 , C07C323/42 , C07C381/00 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/81 , C07D213/82 , C07D239/34 , C07D239/36 , C07D239/38 , C07D257/04 , C07D261/12 , C07D401/12 , C07D413/12 , C07F5/02
CPC classification number: C07C233/62 , A61K31/165 , A61K31/167 , A61K31/41 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/505 , A61K31/513 , A61K31/655 , A61K45/06 , A61P25/00 , A61P31/04 , C07B59/001 , C07C233/78 , C07C235/10 , C07C235/50 , C07C237/42 , C07C245/08 , C07C247/16 , C07C247/18 , C07C317/28 , C07C323/40 , C07C323/42 , C07C381/00 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/81 , C07D213/82 , C07D239/34 , C07D239/36 , C07D239/38 , C07D257/04 , C07D261/12 , C07D401/12 , C07D413/12 , C07F5/02 , C07C2601/08
Abstract: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
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公开(公告)号：US20230142714A1
公开(公告)日：2023-05-11
申请号：US17740260
申请日：2022-05-09
Applicant: CORTEXYME, INC.
Inventor： Andrei W. Konradi , Robert A. Galemmo, JR. , Stephen S. Dominy , Casey C. Lynch , Leslie J. Holsinger
IPC: C07C233/62 , C07D401/12 , A61K31/655 , A61K31/165 , C07C245/08 , C07C323/42 , C07C247/18 , C07D261/12 , C07C237/42 , C07D213/82 , A61K31/513 , C07D239/34 , C07D239/36 , A61P31/04 , C07F5/02 , A61K31/4402 , A61K31/4439 , A61K31/4409 , C07D413/12 , C07C323/40 , A61K31/4406 , A61K31/505 , C07C233/78 , C07C235/50 , A61K31/44 , C07D257/04 , A61K45/06 , C07D239/38 , C07C317/28 , A61K31/42 , C07C381/00 , C07D213/81 , A61K31/41 , C07D213/65 , C07C247/16 , C07D213/70 , C07B59/00 , A61K31/167 , C07C235/10 , C07D213/68 , A61P25/00
CPC classification number: C07C233/62 , C07D401/12 , A61K31/655 , A61K31/165 , C07C245/08 , C07C323/42 , C07C247/18 , C07D261/12 , C07C237/42 , C07D213/82 , A61K31/513 , C07D239/34 , C07D239/36 , A61P31/04 , C07F5/02 , A61K31/4402 , A61K31/4439 , A61K31/4409 , C07D413/12 , C07C323/40 , A61K31/4406 , A61K31/505 , C07C233/78 , C07C235/50 , A61K31/44 , C07D257/04 , A61K45/06 , C07D239/38 , C07C317/28 , A61K31/42 , C07C381/00 , C07D213/81 , A61K31/41 , C07D213/65 , C07C247/16 , C07D213/70 , C07B59/001 , A61K31/167 , C07C235/10 , C07D213/68 , A61P25/00 , C07C2601/08
Abstract: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
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公开(公告)号：US11325884B2
公开(公告)日：2022-05-10
申请号：US16899376
申请日：2020-06-11
Applicant: CORTEXYME, INC.
Inventor： Andrei W. Konradi , Robert A. Galemmo, Jr. , Stephen S. Dominy , Casey C. Lynch , Leslie J. Holsinger
IPC: C07C233/62 , C07D213/82 , C07D239/34 , C07D239/36 , C07D413/12 , C07D257/04 , C07D261/12 , C07D213/70 , C07C317/28 , C07C233/78 , C07C235/10 , C07C235/50 , C07B59/00 , C07C237/42 , C07D401/12 , C07C381/00 , C07C323/42 , C07D213/65 , C07D213/68 , C07D239/38 , C07C247/18 , C07F5/02 , A61P31/04 , A61P25/00 , A61K31/165 , A61K31/167 , A61K31/41 , A61K31/42 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/505 , A61K31/513 , A61K31/655 , A61K45/06 , C07C245/08 , C07C247/16 , C07C323/40 , C07D213/81
Abstract: The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
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