公开(公告)号：US11325884B2

公开(公告)日：2022-05-10

申请号：US16899376

申请日：2020-06-11

申请人： CORTEXYME, INC.

发明人： Andrei W. Konradi ,  Robert A. Galemmo, Jr. ,  Stephen S. Dominy ,  Casey C. Lynch ,  Leslie J. Holsinger

IPC分类号： C07C233/62 ,  C07D213/82 ,  C07D239/34 ,  C07D239/36 ,  C07D413/12 ,  C07D257/04 ,  C07D261/12 ,  C07D213/70 ,  C07C317/28 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07B59/00 ,  C07C237/42 ,  C07D401/12 ,  C07C381/00 ,  C07C323/42 ,  C07D213/65 ,  C07D213/68 ,  C07D239/38 ,  C07C247/18 ,  C07F5/02 ,  A61P31/04 ,  A61P25/00 ,  A61K31/165 ,  A61K31/167 ,  A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/513 ,  A61K31/655 ,  A61K45/06 ,  C07C245/08 ,  C07C247/16 ,  C07C323/40 ,  C07D213/81

摘要： The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

公开(公告)号：US10689480B2

公开(公告)日：2020-06-23

申请号：US16073107

申请日：2016-03-01

申请人： TOYO TIRE & RUBBER CO., LTD.

发明人： Yuki Hidaka

IPC分类号： C08G18/48 ,  C07C43/23 ,  C07C245/08 ,  C09K19/14 ,  C09K19/24 ,  C09K19/12 ,  C09K19/22 ,  C07C251/24 ,  C07C235/56 ,  C08G18/32 ,  C08G18/38 ,  C08G18/72 ,  C08G18/73 ,  C08G18/76

摘要： One purpose of the present invention is to provide a liquid-crystal compound which exhibits liquid crystallinity at low temperatures. Another purpose of the present invention is to provide a thermally responsive material which exhibits liquid crystallinity and rubber elasticity at low temperatures (around room temperature) ever, though a large amount of a liquid-crystal compound is contained therein, and a method for producing this thermally responsive material. A liquid-crystal compound according to the present invention is obtained by adding an alkylene oxide and/or styrene oxide to a mesogenic group-containing compound that has an active hydrogen group.

公开(公告)号：US10301430B2

公开(公告)日：2019-05-28

申请号：US15715414

申请日：2017-09-26

申请人： The United States of America, as represented by the Secretary of the Air Force

发明人： Loon-Seng Tan ,  David Huabin Wang ,  Jeong Jae Wie ,  Timothy J. White

IPC分类号： C08G73/10 ,  C07C323/48 ,  C07C245/08 ,  C08G69/32 ,  C09B35/021 ,  C09B69/10 ,  C09B43/16

摘要： Bis(azo-benzene) diamine monomers and a method of synthesizing the monomers are provided. The bis(azo-benzene) diamine monomers, in combination with amine reactive monomers, form polymers, such as polyimides and copolyimides, having photomechanical and thermomechanical properties.

公开(公告)号：US20180230385A1

公开(公告)日：2018-08-16

申请号：US15954045

申请日：2018-04-16

申请人： DIC Corporation

发明人： Fumiaki Kodera ,  Yoshitaka Saito ,  Hiroshi Hasebe ,  Masanao Takashima ,  Shuuhei Yamamoto ,  Kouzi Satou ,  Sayaka Nose ,  Kazuki Obi ,  Hiroyuki Itou

IPC分类号： C09K19/56 ,  C07C245/08 ,  C08F220/30 ,  C08F222/20 ,  G02F1/1337

摘要： A compound and a polymer which can each form a photo-alignment film having excellent ability of controlling alignment, a photo-alignment film obtained using the polymer and an optically anisotropic body and a liquid crystal display element each having the photo-alignment film are provided. A compound represented by the general formula (1). In the formula, P represents a polymerizable group, Z and Z1 represent divalent linking groups, A and A1 represent divalent cyclic groups, and X1 to X5 each independently represent a hydrogen atom, a fluorine atom, a chlorine atom, a hydroxy group, a nitro group, a cyano group or an alkyl group having 1 to 40 carbon atoms which may have a substituent, provided that X1, X2, X4 and X5 are not simultaneously hydrogen atoms.

公开(公告)号：US09758469B2

公开(公告)日：2017-09-12

申请号：US14926178

申请日：2015-10-29

申请人： Noxell Corporation

发明人： Garry Steven Garrett ,  Heike Gertrud Abel ,  Armin Osan ,  John Michael Gardlik ,  Bryan Patrick Murphy ,  Markus Speckbacher ,  Ingo Reinhold Weber

IPC分类号： C07C213/02 ,  C07C245/20 ,  C07C245/24 ,  C07C245/08

CPC分类号： C07C213/02 ,  C07C245/08 ,  C07C245/20 ,  C07C245/24 ,  C07C217/76

摘要： A process for the preparation of 2-substituted-1,4-benzenediamines, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely the 2-substituted aniline.

公开(公告)号：US20170240504A1

公开(公告)日：2017-08-24

申请号：US15518679

申请日：2015-12-02

申请人： LG Chem, Ltd. ,  IUCF-HYU (Industry-University Cooperation Foundation Hanyang University)

发明人： Yang Kyoo Han ,  In-Joon Byun ,  Sung Soo Yoon ,  Je Gwon Lee

IPC分类号： C07C245/08 ,  G01N33/20 ,  C08F120/36

CPC分类号： C07C245/08 ,  C08F20/34 ,  C08F120/36 ,  G01N33/1813 ,  G01N33/20

摘要： According to one embodiment of the present invention, an azo polymer forms a complex with a lithium ion and a sodium ion among alkali metal ions, but does not form a complex with a potassium ion. Therefore, the azo polymer is expected to be utilized as a material for a sensor capable of selectively detecting a specific alkali metal ion, or as a novel material capable of selectively trapping a specific alkali metal ion from a solution in which metal ions are mixed.

公开(公告)号：US20170226052A1

公开(公告)日：2017-08-10

申请号：US15205083

申请日：2016-07-08

申请人： NATIONAL CHUNG SHAN INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： WEN-CHIUNG SU ,  RU-JONG JENG ,  CHIEN-HSIN WU ,  YU-WEN LAI ,  SHIH-CHIEH YEH

IPC分类号： C07C245/08

CPC分类号： C07C245/08 ,  C08G69/00

摘要： Epoxy/MMT composite material and a crosslinking method for epoxy/MMT composite material with second order nonlinear optical properties are introduced. Chromophore-containing intercalating agents are applied to modify montmorillonites (MMTs) to form organoclays by an ion-exchange process, wherein the chrmophores are neatly packed on exfoliated epoxy/organoclay nanocomposites. As a result, optical nonlinearity, i.e. the Pockels effect is observed for the nanocomposites without resorting to the poling process due to self-assembly process. Furthermore, a series of epoxy/MMT nanocomposites comprising thermally reversible furan-norbornene Diels-Alder adducts are prepared to establish a crosslinking feature. Self-alignment behavior, electro-optical (EO) coefficient and temporal stability of the epoxy/MMT nanocomposites are improved by the Diels-Alders crosslinking.

公开(公告)号：US09365501B2

公开(公告)日：2016-06-14

申请号：US14397352

申请日：2013-04-30

申请人： KOWA COMPANY, LTD.

发明人： Masahiro Tamura ,  Takahide Oshita

IPC分类号： C07C245/08 ,  A61L27/16 ,  C08F220/68 ,  C09B29/12 ,  C08F220/60 ,  A61L27/50 ,  C09B29/01 ,  C09B69/10

CPC分类号： C07C245/08 ,  A61F2/16 ,  A61F2002/16965 ,  A61L27/16 ,  A61L27/50 ,  A61L2430/16 ,  C08F220/00 ,  C08F220/60 ,  C08F220/68 ,  C09B29/0003 ,  C09B29/12 ,  C09B69/106 ,  C08L33/26

摘要： A polymerizable UV-absorbing colorant monomer is provided, which is excellent in stability under alkaline conditions and which is available for a useful material polymer for an intraocular lens. A compound, which is represented by the following general formula (1), is used as a polymerizable UV-absorbing monomer available for a material polymer for an intraocular lens: (in the general formula (1), R1 is a hydrogen atom, a hydroxy group, a carboxy group, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a sulfonic acid group, or a benzyloxy group, R2 is a hydrogen atom, a hydroxy group, or an alkoxy group having 1 to 4 carbon atoms, and R3 is represented by the following formula (2)): (in the general formula (2), R4 is a hydrogen atom or a methyl group, and R5 is a single bond or an alkylene group having 1 to 4 carbon atoms which may have a substituent or substituents.)

摘要翻译： 提供了一种可聚合的UV吸收着色剂单体，其在碱性条件下的稳定性优异，并且可用于眼内透镜的有用材料聚合物。 使用由以下通式（1）表示的化合物作为可用于眼内透镜材料聚合物的可聚合的UV吸收单体：（在通式（1）中，R 1是氢原子， 羟基，羧基，碳原子数1〜8的烷基，碳原子数1〜8的烷氧基，磺酸基或苄氧基，R2是氢原子，羟基或烷氧基 具有1至4个碳原子的基团，R 3由下式（2）表示）：（在通式（2）中，R 4是氢原子或甲基，R 5是单键或亚烷基 具有1至4个可具有取代基的碳原子。）

公开(公告)号：US09255065B1

公开(公告)日：2016-02-09

申请号：US13866524

申请日：2013-04-19

申请人： The United States of America, as represented by the Secretary of the Air Force

发明人： Loon-Seng Tan ,  David Huabin Wang

IPC分类号： C07C245/08

CPC分类号： C07C245/08 ,  C07C217/90 ,  C07F9/5325 ,  C08G73/1085

摘要： Photo-active cross-linkers derived from a tris(azobenzene)-containing compound with the following generic structure: wherein for meta-azo substitution, R is equal to H, and for para-azo substitution, R is selected from the group consisting of H, F, Cl, CF3, and CH3.

摘要翻译： 衍生自具有以下一般结构的三（偶氮苯）的化合物的光活性交联剂：其中对于偶氮偶氮取代，R等于H，对偶氮取代为R选自 H，F，Cl，CF 3，和CH 3。

公开(公告)号：US09126899B2

公开(公告)日：2015-09-08

申请号：US14361599

申请日：2012-11-30

申请人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

发明人： Yasuo Norikane

IPC分类号： C07C245/08 ,  C09K9/02 ,  C09J201/00 ,  C09J11/06 ,  C08K5/23

CPC分类号： C07C245/08 ,  C08K5/23 ,  C09B29/0003 ,  C09B29/12 ,  C09B43/28 ,  C09J11/06 ,  C09J201/00 ,  C09K9/02 ,  C09K2211/1007 ,  C09K2211/1014 ,  G03F7/004

摘要： The present invention addresses the problem of providing with a simple production process and with high efficiency a new photosensitive azobenzene derivative which is capable of freely controlling phase transition by photostimulation, and the problem is solved by using an azobenzene derivative represented by general formula (1). (1) (In the formula, R1 and R6 are independently an alkoxyl group having 6-18 carbon atoms, R2-R5 and R7-R10 are independently a hydrogen atom or an alkyl group having 1-4 carbon atoms which may have branches, provided that not all of R2-R5 and R7-R10 are hydrogen).

摘要翻译： 本发明解决了提供简单的制备方法和高效率地提供能够通过光刺激自由控制相变的新的感光偶氮苯衍生物的问题，并且通过使用由通式（1）表示的偶氮苯衍生物来解决问题， 。 （1）（式中，R 1和R 6分别为碳原子数为6〜18的烷氧基，R 2 -R 5，R 7 -R 10分别为氢原子或可具有分支的碳原子数为1〜4的烷基， 只要不是所有的R2-R5和R7-R10都是氢）。