公开(公告)号：US11072583B2

公开(公告)日：2021-07-27

申请号：US16767389

申请日：2018-08-06

申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

发明人： Chandrasekhar Srivari ,  Prathama Satyendra Mainkar ,  Chada Raji Reddy ,  Srigiridhar Kotamraju ,  Pavan Kumar Togapur ,  Subbarao Mohan Venkata Muppidi ,  Somesh Sharma ,  Ashok Kumar Jha ,  Prem Kumar Arumugam

IPC分类号： C07D209/40 ,  B01J31/24

摘要： Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R1, R2, R3, R4, R5, and R6 are hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.

公开(公告)号：US10343991B2

公开(公告)日：2019-07-09

申请号：US15802003

申请日：2017-11-02

申请人： Council of Scientific & Industrial Research

发明人： Raji Reddy Chada ,  Srigiridhar Kotamraju ,  Santosh Karnewar ,  Nagendra Babu Bathini ,  Nagarsenkar Atulya ,  Anuradha Singampalli

IPC分类号： C07D209/34 ,  C07D491/048 ,  C07D403/14 ,  C07D409/06 ,  C07D403/06 ,  C07D405/06

摘要： The present invention describes the C5,C6 Substituted and/or fused oxindole compounds useful as anti-cancer agents and process for preparation thereof. Particularly the present invention relates to C5,C6 Substituted and/or fused oxindole compounds of formula I. wherein, A=C, CH, CH2, None B=C or CH part of open chain and/or cyclic alkyl/aryl/heteroaryl moiety G=alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalkyl, alkoxy, aryloxy-all these optionally substituted with one or more substituents D=O, N, S, OH, SH, NH, None Z=C, CH2 Ring E=aryl/heteroaryl/cycloalkyl optionally substituted with one or more substituents Ring C=aryl/heteroaryl/cycloalkyl optionally substituted with one or more substituents L=H, alkyl, alkoxy, halogen, CN, OH, amino, NO2 K=H, alkyl, alkoxy, halogen, CN, OH, amino, NO2 X=H, alkyl, alkoxy, halogen, CN, OH, amino, NO2 Y=H, alkyl, alkoxy, halogen, CN, OH, amino, NO2 R1=H, alkyl R2=H, alkyl, halogen, CN, NO2, alkoxy, amino, OH

公开(公告)号：US20180127365A1

公开(公告)日：2018-05-10

申请号：US15802003

申请日：2017-11-02

申请人： Council of Scientific & Industrial Research

发明人： Raji Reddy CHADA ,  Srigiridhar Kotamraju ,  Santosh Karnewar ,  Nagendra Babu Bathini ,  Nagarsenkar Atulya ,  Anuradha Singampalli

IPC分类号： C07D209/34 ,  C07D491/048 ,  C07D405/06 ,  C07D409/06 ,  C07D403/06 ,  C07D403/14

CPC分类号： C07D209/34 ,  C07D403/06 ,  C07D403/14 ,  C07D405/06 ,  C07D409/06 ,  C07D491/048

摘要： The present invention describes the C5,C6 Substituted and/or fused oxindole compounds useful as anti-cancer agents and process for preparation thereof. Particularly the present invention relates to C5,C6 Substituted and/or fused oxindole compounds of formula I. wherein, A=C, CH, CH2, None B=C or CH part of open chain and/or cyclic alkyl/aryl/heteroaryl moiety G=alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalkyl, alkoxy, aryloxy-all these optionally substituted with one or more substituents D=O, N, S, OH, SH, NH, None Z=C, CH2 Ring E=aryl/heteroaryl/cycloalkyl optionally substituted with one or more substituents Ring C=aryl/heteroaryl/cycloalkyl optionally substituted with one or more substituents L=H, alkyl, alkoxy, halogen, CN, OH, amino, NO2 K=H, alkyl, alkoxy, halogen, CN, OH, amino, NO2 X=H, alkyl, alkoxy, halogen, CN, OH, amino, NO2 Y=H, alkyl, alkoxy, halogen, CN, OH, amino, NO2 R1=H, alkyl R2=H, alkyl, halogen, CN, NO2, alkoxy, amino, OH