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    METHODS FOR PREDICTING OVERALL SURVIVAL OF CANCER PATIENTS BASED ON NUMBERS OF CIRCULATING TUMOR CELLS
    1.
    发明申请
    METHODS FOR PREDICTING OVERALL SURVIVAL OF CANCER PATIENTS BASED ON NUMBERS OF CIRCULATING TUMOR CELLS 审中-公开
    基于循环肿瘤细胞数量预测癌症患者总体存活的方法

    公开(公告)号：US20160178630A1

    公开(公告)日：2016-06-23

    申请号：US14974889

    申请日：2015-12-18

    Applicant: Creatv MicroTech, Inc.

    Inventor： Daniel L. ADAMS ,  Cha-Mei TANG

    IPC: G01N33/574 ,  G01N15/10

    CPC classification number: G01N33/57415 ,  G01N15/1456 ,  G01N33/57492 ,  G01N2001/4088 ,  G01N2015/1062 ,  G01N2333/4742 ,  G01N2333/70589

    Abstract: Cytokeratin (CK)+/CD45−/DAPI+ cells in the blood of cancer patients have been considered by most as circulating tumor cells (CTCs). Different methods of isolating CTCs results in a wide range of numbers and subgroups of CTCs from same patient. As a result, the clinical significance of the number of CTCs becomes cloudy. Provided herein is methodology to categorize CTCs into morphologically distinct subpopulations, and to use one of the subpopulations in methods for predicting overall survival of a patient having cancer.

    Abstract translation: 癌症患者血液中的细胞角蛋白（CK）+ / CD45- / DAPI +细胞被认为是循环肿瘤细胞（CTC）。 分离CTC的不同方法导致来自同一患者的CTC的数量和亚组范围很广。 结果，CTC数量的临床意义变得多云。 本文提供了将CTC分类到形态上不同的亚群的方法，并且在用于预测具有癌症的患者的总体存活的方法中使用一个亚群。

    POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES
    7.
    发明申请
    POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES 审中-公开

    公开(公告)号：US20190324014A1

    公开(公告)日：2019-10-24

    申请号：US16400600

    申请日：2019-05-01

    Applicant: Creatv MicroTech, Inc.

    Inventor： Cha-Mei TANG

    IPC: G01N33/50 ,  B01D39/16 ,  B01L3/00 ,  B01L9/00 ,  B01D29/00 ,  G01N1/40

    Abstract: A microfilter comprising a polymer layer formed from photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer layer. Methods of forming apertures in one or more layers of photo-definable dry film are also disclosed. Filter holder designs and methods appropriate to hold microfilters to collect the rare cells and to perform of assays in the filter holder are provided. Microfiltration chip designs and methods appropriate to collect the rare cells and to perform assays in the microfluidic chips are provided. The invention also describes the use of the microfilter, filter holder and microfilter chips to collect rare cells from body fluids and perform assays, and these rare cells can be used for medical and biological research applications.

    USE OF CIRCULATING TUMOR CELL MITOTIC INDEX IN CANCER STRATIFICATION AND DIAGNOSTICS
    9.
    发明申请
    USE OF CIRCULATING TUMOR CELL MITOTIC INDEX IN CANCER STRATIFICATION AND DIAGNOSTICS 有权

    公开(公告)号：US20220034888A1

    公开(公告)日：2022-02-03

    申请号：US17503872

    申请日：2021-10-18

    Applicant: CREATV MICROTECH INC.

    Inventor： Daniel ADAMS ,  Cha-Mei TANG

    IPC: G01N33/574 ,  G01N33/50

    Abstract: Circulating tumor cells (CTCs) are associated with metastasis of malignant solid tumors in a patient. Presented here is evidence that CTCs exhibit cell cycle phase variability and that there is a strong correlation between the number of CTCs in a mitotic cell cycle phase and the prospects for long term survival of the subject from which the cells were obtained. Also presented herein are methods of determining the mitotic cell cycle phase of CTCs from a patient having cancer and using the information in grading malignant solid tumors and predicting the likelihood of survival of the patient.

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