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公开(公告)号：US11679129B2
公开(公告)日：2023-06-20
申请号：US16958649
申请日：2019-01-10
Inventor： Chan Hyuk Kim , Young-Ho Lee , Yujean Lee , HyeongJi Lee , Sang Hoon Lee
IPC: C12N15/113 , A61K35/17 , A61P35/00 , A61K31/7088 , A61K38/17 , A61K39/395 , C07K14/725 , C07K14/705 , C07K16/28 , C07K14/47 , C12N5/0783 , A61K39/00
CPC classification number: A61K35/17 , A61K31/7088 , A61K38/177 , A61K38/1774 , A61K39/3955 , A61P35/00 , C07K14/4702 , C07K14/7051 , C07K14/70521 , C07K14/70578 , C07K16/2803 , C12N5/0637 , C12N15/1138 , A61K2039/505 , A61K2039/5154 , A61K2039/5158 , C07K2317/53 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33 , C07K2319/715 , C12N2310/122 , C12N2310/14 , C12N2310/531 , C12N2320/31 , C12N2320/32 , C12N2510/00
Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.
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公开(公告)号：US12285438B2
公开(公告)日：2025-04-29
申请号：US17701535
申请日：2022-03-22
Inventor： Chan Hyuk Kim , Young-Ho Lee , Yujean Lee , HyeongJi Lee , Sang Hoon Lee
IPC: A61K31/7088 , A61K38/17 , A61K39/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K14/705 , C07K14/725 , C07K16/28 , C12N5/0783 , C12N15/113
Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.
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