公开(公告)号：US11324798B2

公开(公告)日：2022-05-10

申请号：US16986802

申请日：2020-08-06

申请人： CYTOGEL PHARMA, LLC

发明人： Theodore E. Maione ,  Constantine Basil Maglaris

IPC分类号： A61K38/07 ,  A61P25/36 ,  A61P25/30 ,  A61K38/04

摘要： The subject invention pertains to peptides and salts thereof that are useful as anti-inflammatory agents and to compositions containing such peptides and salts as active ingredients. Specifically exemplified herein are endomorphin-1 peptide (EM-1), analogs and salts thereof, and uses for modulation of calcitonin gene-related peptide (CGRP) production and/or substance P (SP) and for treatment of inflammation, particularly neurogenic inflammation.

公开(公告)号：US12037416B2

公开(公告)日：2024-07-16

申请号：US16609840

申请日：2018-11-19

申请人： CYTOGEL PHARMA, LLC

发明人： Theodore E. Maione ,  James Hamsher ,  Constantine Basil Maglaris

IPC分类号： C07K7/06 ,  A61K38/00 ,  A61K47/54 ,  A61K47/60 ,  A61K47/61 ,  A61K47/62 ,  C07K5/107

CPC分类号： C07K7/06 ,  A61K47/542 ,  A61K47/60 ,  A61K47/61 ,  A61K47/62 ,  C07K5/1016 ,  A61K38/00

摘要： The subject invention provides compositions and methods for alleviating pain. Specifically, the subject invention provides pharmaceutical formulations of polymers, and/or their salts, having advantageous μ-opioid receptor binding activity.

公开(公告)号：US10975121B2

公开(公告)日：2021-04-13

申请号：US15962200

申请日：2018-04-25

申请人： Cytogel Pharma, LLC

发明人： Theodore E. Maione ,  Constantine Basil Maglaris

IPC分类号： C07K5/107 ,  A61K47/40 ,  A61K38/07 ,  A61K47/69 ,  A61K47/61 ,  A61K9/08 ,  A61K31/724

摘要： The subject invention provides compositions and methods for alleviating pain. Specifically, the subject invention provides pharmaceutical formulations of peptides, and/or their salts, having advantageous μ-opioid receptor binding activity.

公开(公告)号：US11603385B2

公开(公告)日：2023-03-14

申请号：US17061728

申请日：2020-10-02

申请人： Cytogel Pharma, LLC.

发明人： Theodore E. Maione ,  Constantine Basil Maglaris

IPC分类号： C07K5/107 ,  A61K47/40 ,  A61K38/07 ,  A61K47/69 ,  A61K47/61 ,  A61K9/08 ,  A61K31/724

摘要： The subject invention provides compositions and methods for alleviating pain. Specifically, the subject invention provides pharmaceutical formulations of peptides, and/or their salts, having advantageous μ-opioid receptor binding activity.

公开(公告)号：US10441625B2

公开(公告)日：2019-10-15

申请号：US16035274

申请日：2018-07-13

申请人： Cytogel Pharma, LLC

发明人： Theodore E. Maione ,  Constantine Basil Maglaris

IPC分类号： A61K38/07

摘要： The subject invention pertains to peptides and salts thereof that are useful as anti-inflammatory agents and to compositions containing such peptides and salts as active ingredients. Specifically exemplified herein are endomorphin-1 peptide (EM-1), analogs and salts thereof, and uses for modulation of calcitonin gene-related peptide (CGRP) production and/or substance P (SP) and for treatment of inflammation, particularly neurogenic inflammation.