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1.发明授权公开(公告)号：US11371994B2
公开(公告)日：2022-06-28
申请号：US14485243
申请日：2014-09-12
Applicant: California Institute of Technology
Inventor： James R. Heath , Arundhati Nag , Samir Das , Joseph O. Varghese , Ryan K. Henning
IPC: C07K7/06 , C12Q1/48 , G01N33/574 , C07K7/08 , G01N33/58
Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
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2.发明申请PHOSPHORYLATED AKT-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING 审中-公开磷酸钾特异性捕获剂，组合物和使用和制备方法公开(公告)号：US20150219657A1
公开(公告)日：2015-08-06
申请号：US14485243
申请日：2014-09-12
Applicant: California Institute of Technology
Inventor： James R. Heath , Arundhati Nag , Samir Das , Joseph O. Varghese , Ryan K. Henning
IPC: G01N33/574 , G01N33/58 , C07K7/06
Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
Abstract translation: 本申请提供了稳定的基于肽的Akt捕获剂以及用作检测和诊断试剂以及用于治疗疾病和病症的方法。 该应用进一步提供了使用迭代的珠粒原位点击化学制造Akt捕获剂的方法。
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3.发明申请公开(公告)号：US20230019342A1
公开(公告)日：2023-01-19
申请号：US17850743
申请日：2022-06-27
Applicant: California Institute of Technology
Inventor： James R. Heath , Arundhati Nag , Samir Das , Joseph O. Varghese , Ryan K. Henning
IPC: G01N33/574 , C07K7/06 , C07K7/08 , C12Q1/48 , G01N33/58
Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
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