公开(公告)号：US12258613B2

公开(公告)日：2025-03-25

申请号：US16492588

申请日：2018-03-08

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： James R. Heath ,  Songming Peng ,  Alphonsus Hon-Chung Ng

IPC: C12Q1/6804 ,  B01L3/00 ,  C12N15/10

Abstract: Compositions and methods for identifying antigen-specific T cells, including determining paired T cell receptor sequences for a specific antigen, are described. Compositions and methods for identifying neoantigen-specific T cells are also described. Microfluidic devices useful for identifying antigen-specific T cells, and methods of using the same, are also described.

公开(公告)号：US20220380409A1

公开(公告)日：2022-12-01

申请号：US17844456

申请日：2022-06-20

Applicant: California Institute of Technology

Inventor： James R. Heath ,  Rosemary Dyane Rohde ,  Arundhati Nag ,  Samir Das ,  Aiko Umeda

IPC: C07K7/64 ,  A61K49/00 ,  C07K5/06 ,  C07K5/08 ,  A61K51/08 ,  C07K1/04 ,  C07K5/10 ,  C07K7/56 ,  C07K14/00 ,  G01N33/573 ,  G01N33/68

Abstract: Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1 Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed.

公开(公告)号：US10913774B2

公开(公告)日：2021-02-09

申请号：US16031840

申请日：2018-07-10

Applicant: California Institute of Technology

Inventor： Ryan K. Henning ,  Ashwin N. Ram ,  Samir Das ,  Arundhati Nag ,  James R. Heath

IPC: A61K38/00 ,  C07K7/64 ,  G01N33/574 ,  C07K14/82 ,  C07K7/06

Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.

公开(公告)号：US09595653B2

公开(公告)日：2017-03-14

申请号：US13853987

申请日：2013-03-29

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Slobodan Mitrovic ,  Jen-Kan Yu ,  James R. Heath

IPC: H01L35/26 ,  H01L21/22

CPC classification number: H01L35/26 ,  H01L21/22 ,  H01L35/32 ,  H01L35/34 ,  Y10T428/24273 ,  Y10T428/24802

Abstract: Phononic structures, devices related to phononic structures, and methods related to fabrication of the phononic structures are described. The phononic structure can include a sheet of material, where the sheet of material can include a plurality of regions. Adjacent regions in the sheet of material can have dissimilar phononic patterns.

Abstract translation: 描述了声子结构，与声子结构有关的装置，以及与声子结构的制造有关的方法。 声子结构可以包括一片材料，其中该片材料可以包括多个区域。 材料片中的相邻区域可以具有不同的声子模式。

公开(公告)号：US20170052199A1

公开(公告)日：2017-02-23

申请号：US15211759

申请日：2016-07-15

Applicant: California Institute of Technology ,  Indi Molecular, Inc.

Inventor： James R. Heath ,  Heather Agnew ,  Blake Farrow ,  David Bunck ,  Jingxin Liang ,  Arundhati Nag ,  Samir Das ,  Bert Tsunyin Lai ,  Suresh Mark Pitram

IPC: G01N33/68 ,  C07K7/64

CPC classification number: G01N33/6869 ,  C07K7/06 ,  C07K7/64 ,  C07K14/54 ,  C07K2319/00 ,  G01N2333/54

Abstract: The present application provides stable peptide-based IL-17F capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.

Abstract translation: 本申请提供稳定的基于肽的IL-17F捕获剂和用作检测剂的方法。 该应用进一步提供了制造IL-17F捕获剂的方法。

公开(公告)号：US20150093758A1

公开(公告)日：2015-04-02

申请号：US14444328

申请日：2014-07-28

Applicant: Indi Molecular, Inc. ,  California Institute of Technology

Inventor： James R. Heath ,  Heather Dawn Agnew ,  Suresh Mark Pitram

IPC: G01N33/574 ,  C07K14/00

CPC classification number: G01N33/57434 ,  A61K47/545 ,  A61K47/551 ,  C07K7/08 ,  C07K14/001 ,  C12N9/6424 ,  G01N2333/96455

Abstract: Disclosed herein are novel synthetic prostate specific antigen (PSA)-targeted capture agents that specifically bind PSA. In certain embodiments, these PSA capture agents are biligand or triligand capture agents containing two or three target-binding moieties, respectively.

Abstract translation: 本文公开了特异性结合PSA的新型合成前列腺特异性抗原（PSA）靶向捕获剂。 在某些实施方案中，这些PSA捕获剂分别是含有两个或三个靶结合部分的双配位体或三配位体捕获剂。

公开(公告)号：US20240280573A1

公开(公告)日：2024-08-22

申请号：US18469907

申请日：2023-09-19

Applicant: California Institute of Technology

Inventor： Rong Fan ,  Habib Ahmad ,  James R. Heath

IPC: G01N33/543 ,  B01J19/00 ,  B01L3/00 ,  G01N33/58

CPC classification number: G01N33/54393 ,  B01J19/0046 ,  B01L3/502746 ,  B01L3/502753 ,  G01N33/54366 ,  G01N33/582 ,  B01J2219/00547 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00621 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2300/0636 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/084 ,  G01N2458/10

Abstract: Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.

公开(公告)号：US11719705B2

公开(公告)日：2023-08-08

申请号：US16010347

申请日：2018-06-15

Applicant: Indi Molecular, Inc. ,  California Institute of Technology

Inventor： Heather Agnew ,  Bert Tsunyin Lai ,  Suresh Mark Pitram ,  Blake Farrow ,  James R. Heath ,  David Bunck ,  Jingxin Liang ,  Arundhati Nag ,  Samir Das

IPC: G01N33/68 ,  C07K7/06 ,  C07K14/54

CPC classification number: G01N33/6869 ,  C07K7/06 ,  C07K14/54

Abstract: The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.

公开(公告)号：US11371994B2

公开(公告)日：2022-06-28

申请号：US14485243

申请日：2014-09-12

Applicant: California Institute of Technology

Inventor： James R. Heath ,  Arundhati Nag ,  Samir Das ,  Joseph O. Varghese ,  Ryan K. Henning

IPC: C07K7/06 ,  C12Q1/48 ,  G01N33/574 ,  C07K7/08 ,  G01N33/58

Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US11353448B2

公开(公告)日：2022-06-07

申请号：US15045241

申请日：2016-02-16

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Min Xue ,  Wei Wei ,  James R. Heath

IPC: G01N33/53 ,  G01N33/573

Abstract: Methods and compositions for quantifying the cellular concentration of cyclic adenosine monophosphate (cAMP), cyclic guanine monophosphate (cGMP), glutathione, glucose, and glutamine in a single cell include the use of conjugates and analogs in immunofluorescent assays for on-chip quantification. These metabolite immunofluorescent assays may be incorporated with proteomic assays for simultaneous single cell analysis of metabolites and proteins.