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1.发明授权Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof 有权手性烯胺酮的合成及其衍生物及其生物活性研究公开(公告)号：US09518034B2
公开(公告)日：2016-12-13
申请号：US14514001
申请日：2014-10-14
Applicant: California Institute of Technology
Inventor： Brian M. Stoltz , Dennis A. Dougherty , Douglas Duquette , Noah Duffy
IPC: C07D295/116 , C07D209/88
CPC classification number: C07D295/116 , C07D209/88
Abstract: This invention provides enantioenriched heterocyclic enaminone compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.
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