公开(公告)号：US11702546B2

公开(公告)日：2023-07-18

申请号：US16661535

申请日：2019-10-23

Applicant: California Institute of Technology

Inventor： John B. Jarman ,  Dennis A. Dougherty

IPC: C09B23/08 ,  A61N5/06

CPC classification number: C09B23/086 ,  A61N5/062 ,  A61N2005/0659

Abstract: This current disclosure is directed to charge-transfer heptamethine dyes for NIR singlet oxygen generation, each such dye comprising a near-infrared (NIR) absorbing dye having heptamethine linkages orthogonally coupled to an optionally substituted cationic heteroaryl ring moiety as a charge-transfer partner and uses thereof.

公开(公告)号：US10406227B2

公开(公告)日：2019-09-10

申请号：US14650208

申请日：2013-12-18

Applicant: University of Southern California ,  California Institute of Technology

Inventor： Robert H. Chow ,  Mark S. Humayun ,  Harry B. Gray ,  Robert H. Grubbs ,  Dennis A. Dougherty ,  Mark E. Thompson ,  Lionel E. Cheruzel ,  Melanie A. Yen

IPC: A61K41/00 ,  C12N13/00 ,  A61N5/06 ,  A61B3/113

Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.

公开(公告)号：US10232043B2

公开(公告)日：2019-03-19

申请号：US15240997

申请日：2016-08-18

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Melanie A. Yen ,  Dennis A. Dougherty ,  Robert H. Grubbs ,  Harry B. Gray ,  Robert H. Chow ,  Mark S. Humayun ,  Mark E. Thompson ,  Lionel E. Cheruzel

IPC: C12N13/00 ,  A61K41/00 ,  A61N5/06 ,  A61F9/007

Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.

公开(公告)号：US20140311890A1

公开(公告)日：2014-10-23

申请号：US14362887

申请日：2012-12-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Dennis A. Dougherty ,  Robert H. Grubbs ,  Clinton J. Regan

IPC: B01J19/12 ,  C07D209/20 ,  C07D209/12 ,  C07C59/66

CPC classification number: B01J19/122 ,  A61K9/0085 ,  A61K41/0042 ,  A61K47/54 ,  A61K47/545 ,  A61K47/64 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  A61N5/062 ,  A61N2005/0659 ,  C07C59/66 ,  C07D209/12 ,  C07D209/20

Abstract: A photoacid compound having a light absorbing moiety attaching a payload moiety through a linker, in which the linker comprises a geminal dialkyl linked to a carbonyl group attaching the payload moiety, and the linker is configured to present the carbonyl oxygen for reaction with a hydroxyl group presented on the light absorbing moiety in ortho position to the linker.

Abstract translation: 具有光吸收部分的光酸化合物，其通过接头连接有效载荷部分，其中连接体包含与连接有效载荷部分的羰基连接的偕二烷基，连接体被配置为呈现羰基氧以与羟基反应 呈现在与接头相邻的光吸收部分上。

公开(公告)号：US20140308208A1

公开(公告)日：2014-10-16

申请号：US14362888

申请日：2012-12-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Dennis A. Dougherty ,  Robert H. Grubbs ,  Mark Humayun ,  Clinton J. Regan ,  Azita Emami-Neyestanak

IPC: A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61N5/06

CPC classification number: B01J19/122 ,  A61K9/0085 ,  A61K41/0042 ,  A61K47/54 ,  A61K47/545 ,  A61K47/64 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  A61N5/062 ,  A61N2005/0659 ,  C07C59/66 ,  C07D209/12 ,  C07D209/20

Abstract: Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength absorber, the long wavelength being a wavelength greater than or equal to 750 nm; and irradiating the biological environment to excite the long wavelength absorber with light at a wavelength in a range from 900-1100 nm, thus decaging the compound.

Abstract translation: 描述了相关的装置，组合物和系统，其中将笼式化合物施用于生物环境，笼式化合物用长波长吸收剂笼养，长波长为大于或等于750nm的波长; 并照射生物环境以用900-1100nm波长的光激发长波长吸收剂，从而分解化合物。

公开(公告)号：US20170189530A1

公开(公告)日：2017-07-06

申请号：US15240997

申请日：2016-08-18

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Melanie A. Yen ,  Dennis A. Dougherty ,  Robert H. Grubbs ,  Harry B. Gray ,  Robert H. Chow ,  Mark S. Humayun ,  Mark Thompson ,  Oliver Shafaat ,  Erin Lamb

IPC: A61K41/00 ,  A61F9/007 ,  A61N5/06

CPC classification number: A61K41/0057 ,  A61F9/0079 ,  A61K41/00 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/0626 ,  A61N2005/0648

Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.

公开(公告)号：US09636656B2

公开(公告)日：2017-05-02

申请号：US14362888

申请日：2012-12-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Dennis A. Dougherty ,  Robert H. Grubbs ,  Mark Humayun ,  Clinton J. Regan ,  Azita Emami

IPC: A61K41/00 ,  A61K49/00 ,  B01J19/12 ,  A61K9/00 ,  A61K47/48 ,  A61N5/06 ,  C07C59/66 ,  C07D209/12 ,  C07D209/20

CPC classification number: B01J19/122 ,  A61K9/0085 ,  A61K41/0042 ,  A61K47/54 ,  A61K47/545 ,  A61K47/64 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  A61N5/062 ,  A61N2005/0659 ,  C07C59/66 ,  C07D209/12 ,  C07D209/20

Abstract: Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength absorber, the long wavelength being a wavelength greater than or equal to 750 nm; and irradiating the biological environment to excite the long wavelength absorber with light at a wavelength in a range from 900-1100 nm, thus decaging the compound.

公开(公告)号：US09518034B2

公开(公告)日：2016-12-13

申请号：US14514001

申请日：2014-10-14

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Dennis A. Dougherty ,  Douglas Duquette ,  Noah Duffy

IPC: C07D295/116 ,  C07D209/88

CPC classification number: C07D295/116 ,  C07D209/88

Abstract: This invention provides enantioenriched heterocyclic enaminone compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II): with a transition metal catalyst under alkylation conditions.