公开(公告)号：US20210060185A1

公开(公告)日：2021-03-04

申请号：US17006591

申请日：2020-08-28

Applicant: California Institute of Technology

Inventor： Anupama LAKSHMANAN ,  Mikhail SHAPIRO ,  Suchita P. NETY ,  Zhiyang JIN

IPC: A61K49/22 ,  C07K14/195 ,  C12Q1/37

Abstract: Provided herein are engineered protease sensitive gas vesicles and related engineered protease genetically GvpC constructs, vectors, gas vesicles gene clusters, genetic circuits, cells, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging technique, to detect and report protease activity and related biological events in an imaging target site.