公开(公告)号：US20180028693A1

公开(公告)日：2018-02-01

申请号：US15613104

申请日：2017-06-02

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anupama LAKSHMANAN ,  Arash FARHADI ,  Suchita P. NETY ,  Raymond W. BOURDEAU ,  Mikhail SHAPIRO

IPC: A61K49/22 ,  A61B8/08

CPC classification number: A61K49/223 ,  A61B8/481 ,  A61B8/5238 ,  A61K49/0002 ,  A61K49/0045 ,  A61K49/0093 ,  A61K49/221 ,  C07K14/195 ,  C07K2319/00

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

公开(公告)号：US20230277695A1

公开(公告)日：2023-09-07

申请号：US18046881

申请日：2022-10-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anupama LAKSHMANAN ,  Arash FARHADI ,  Suchita P. NETY ,  Raymond W. BOURDEAU ,  Mikhail SHAPIRO

IPC: A61K49/22 ,  A61B8/08 ,  C07K14/195 ,  A61K49/00

CPC classification number: A61K49/223 ,  A61B8/481 ,  A61K49/0002 ,  A61K49/0045 ,  A61K49/0093 ,  A61K49/221 ,  C07K14/195 ,  A61B8/5238 ,  C07K2319/00

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

公开(公告)号：US20210060185A1

公开(公告)日：2021-03-04

申请号：US17006591

申请日：2020-08-28

Applicant: California Institute of Technology

Inventor： Anupama LAKSHMANAN ,  Mikhail SHAPIRO ,  Suchita P. NETY ,  Zhiyang JIN

IPC: A61K49/22 ,  C07K14/195 ,  C12Q1/37

Abstract: Provided herein are engineered protease sensitive gas vesicles and related engineered protease genetically GvpC constructs, vectors, gas vesicles gene clusters, genetic circuits, cells, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging technique, to detect and report protease activity and related biological events in an imaging target site.

公开(公告)号：US20200164095A1

公开(公告)日：2020-05-28

申请号：US16656417

申请日：2019-10-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anupama LAKSHMANAN ,  Arash FARHADI ,  Suchita P. NETY ,  Raymond W. BOURDEAU ,  Mikhail SHAPIRO

IPC: A61K49/22 ,  A61K49/00 ,  C07K14/195 ,  A61B8/08

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.