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公开(公告)号:US20170107258A1
公开(公告)日:2017-04-20
申请号:US15372732
申请日:2016-12-08
发明人: Joerg Bartsch , Garrit Koller
CPC分类号: C07K7/56 , A61K38/00 , A61K38/005 , A61K38/12 , C07K5/0202 , C07K5/12 , C07K5/123 , C07K5/126 , C07K7/06 , C07K7/64 , C07K14/8146 , C07K16/40 , C07K2317/76 , C12N9/6489 , C12Y304/24046
摘要: The invention relates to a method for inhibiting an ADAM protease, comprising inhibiting binding to an integrin-binding loop of a disintegrin domain in the ADAM protease. Also provided are cyclic peptides which inhibit binding to an integrin-binding loop of an ADAM protease, as well as associated pharmaceutical compositions, uses and methods of treatment.
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公开(公告)号:US10472393B2
公开(公告)日:2019-11-12
申请号:US15372732
申请日:2016-12-08
发明人: Joerg Bartsch , Garrit Koller
IPC分类号: C07K4/00 , C07K5/00 , C07K5/12 , C07K7/64 , A61K38/03 , A61K38/12 , C07K7/56 , A61K38/00 , C07K5/02 , C07K14/81 , C12N9/64 , C07K7/06 , C07K16/40
摘要: The invention relates to a method for inhibiting an ADAM protease, comprising inhibiting binding to an integrin-binding loop of a disintegrin domain in the ADAM protease. Also provided are cyclic peptides which inhibit binding to an integrin-binding loop of an ADAM protease, as well as associated pharmaceutical compositions, uses and methods of treatment.
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