公开(公告)号：US20140323435A1

公开(公告)日：2014-10-30

申请号：US14285007

申请日：2014-05-22

申请人： Cancer Research Technology Limited ,  Cephalon, Inc.

发明人： Bruce D. Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R. Ott ,  Jonathan R.A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC分类号： C07D495/04 ,  C07D495/20 ,  C07F7/08 ,  C07D495/14

CPC分类号： C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07D519/00 ,  C07F7/0812

摘要： The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

摘要翻译： 本申请提供式（I）化合物或其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，A，G，M，Q和X如本文所定义。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。

公开(公告)号：US20170158706A1

公开(公告)日：2017-06-08

申请号：US15417191

申请日：2017-01-26

申请人： Cancer Research Technology Limited

发明人： Bruce D. Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R. Ott ,  Jonathan R.A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC分类号： C07D495/04 ,  C07D495/20 ,  C07D495/14 ,  C07D519/00

CPC分类号： C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07D519/00 ,  C07F7/0812

摘要： The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US10954251B2

公开(公告)日：2021-03-23

申请号：US16212582

申请日：2018-12-06

申请人： Cancer Research Technology Limited

发明人： Bruce D. Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R. Ott ,  Jonathan R. A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC分类号： C07D495/04 ,  C07D495/20 ,  C07D495/14 ,  C07F7/08 ,  C07D519/00

摘要： The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US09604994B2

公开(公告)日：2017-03-28

申请号：US14285007

申请日：2014-05-22

申请人： Cancer Research Technology Limited ,  Ignyta, Inc.

发明人： Bruce D Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R Ott ,  Jonathan R. A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC分类号： C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07F7/08 ,  A61P35/00

CPC分类号： C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07D519/00 ,  C07F7/0812

摘要： The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US10183950B2

公开(公告)日：2019-01-22

申请号：US15417191

申请日：2017-01-26

申请人： Cancer Research Technology Limited

发明人： Bruce D. Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R. Ott ,  Jonathan R. A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC分类号： C07D495/04 ,  A61K31/519 ,  C07D495/14 ,  C07D495/20 ,  C07D519/00 ,  C07F7/08 ,  A61P35/02 ,  A61P35/04

摘要： The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.