公开(公告)号：US20170158706A1

公开(公告)日：2017-06-08

申请号：US15417191

申请日：2017-01-26

Applicant: Cancer Research Technology Limited

Inventor： Bruce D. Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R. Ott ,  Jonathan R.A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC: C07D495/04 ,  C07D495/20 ,  C07D495/14 ,  C07D519/00

CPC classification number: C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07D519/00 ,  C07F7/0812

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US09604994B2

公开(公告)日：2017-03-28

申请号：US14285007

申请日：2014-05-22

Applicant: Cancer Research Technology Limited ,  Ignyta, Inc.

Inventor： Bruce D Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R Ott ,  Jonathan R. A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC: C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07F7/08 ,  A61P35/00

CPC classification number: C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07D519/00 ,  C07F7/0812

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US09914730B2

公开(公告)日：2018-03-13

申请号：US14038915

申请日：2013-09-27

Applicant: Ignyta, Inc. ,  Cancer Research Technology Limited

Inventor： Henry J. Breslin ,  Bruce D. Dorsey ,  Benjamin J Dugan ,  Katherine M. Fowler ,  Robert L Hudkins ,  Eugen F. Mesaros ,  Nathaniel J. T. Monck ,  Emma L. Morris ,  Ikeoluwa Olowoye ,  Gregory R. Ott ,  Gregoire A. Pave ,  Jonathan R. Roffey ,  Christelle N. Soudy ,  Ming Tao ,  Craig A. Zificsak ,  Allison L. Zulli

IPC: A61K31/675 ,  C07D471/04 ,  C07D519/00 ,  C07D493/08 ,  C07D498/04 ,  C07F9/6584

CPC classification number: C07D471/04 ,  C07D493/08 ,  C07D498/04 ,  C07D519/00 ,  C07F9/6584

Abstract: The present application provides azaquinazoline compounds as defined herein. This application further describes compositions comprising the same. These azaquinazoline compounds and their salts have atypical protein kinase C (“aPKC”) inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US20140323435A1

公开(公告)日：2014-10-30

申请号：US14285007

申请日：2014-05-22

Applicant: Cancer Research Technology Limited ,  Cephalon, Inc.

Inventor： Bruce D. Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R. Ott ,  Jonathan R.A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC: C07D495/04 ,  C07D495/20 ,  C07F7/08 ,  C07D495/14

CPC classification number: C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07D519/00 ,  C07F7/0812

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

Abstract translation: 本申请提供式（I）化合物或其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，A，G，M，Q和X如本文所定义。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。

公开(公告)号：US10954251B2

公开(公告)日：2021-03-23

申请号：US16212582

申请日：2018-12-06

Applicant: Cancer Research Technology Limited

Inventor： Bruce D. Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R. Ott ,  Jonathan R. A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC: C07D495/04 ,  C07D495/20 ,  C07D495/14 ,  C07F7/08 ,  C07D519/00

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have a PKC inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US10414763B2

公开(公告)日：2019-09-17

申请号：US14668022

申请日：2015-03-25

Applicant: CANCER RESEARCH TECHNOLOGY LIMITED

Inventor： Bruce D. Dorsey ,  Benjamin J. Dugan ,  Katherine M. Fowler ,  Robert L. Hudkins ,  Eugen F. Mesaros ,  Nathaniel J T Monck ,  Emma L. Morris ,  Ikeoluwa Olowoye ,  Gregory R. Ott ,  Gregoire A. Pave ,  Jonathan R. A. Roffey ,  Christelle N. Soudy ,  Craig A. Zificsak ,  Allison L. Zulli

IPC: C07D471/04 ,  C07D519/00 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61K31/437

Abstract: The present application provides a compound of formula (I) and/or a salt thereof, wherein R1, G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders. Compositions comprising a compound of Formula (I) and/or a salt thereof are also provided.

公开(公告)号：US20140113882A1

公开(公告)日：2014-04-24

申请号：US14038915

申请日：2013-09-27

Applicant: Cancer Research Technology Limited ,  Cephalon, Inc.

Inventor： Henry J. Breslin ,  Bruce D. Dorsey ,  Benjamin J. Dugan ,  Katherine M. Fowler ,  Robert L. Hudkins ,  Eugen F. Mesaros ,  Nathaniel J.T. Monck ,  Emma L. Morris ,  Ikeoluwa Olowoye ,  Gregory R. Ott ,  Gregoire A. Pave ,  Jonathan R. Roffey ,  Christelle N. Soudy ,  Ming Tao ,  Craig A. Zificsak ,  Allison L. Zulli

IPC: C07D471/04 ,  C07F9/6584 ,  C07D498/04 ,  C07D493/08

CPC classification number: C07D471/04 ,  C07D493/08 ,  C07D498/04 ,  C07D519/00 ,  C07F9/6584

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

Abstract translation: 本申请提供式（I）化合物或其盐，其中R 7，R 8，R 9，G和X如本文所定义。 本申请进一步描述了包含该组合物的组合物。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。

公开(公告)号：US10183950B2

公开(公告)日：2019-01-22

申请号：US15417191

申请日：2017-01-26

Applicant: Cancer Research Technology Limited

Inventor： Bruce D. Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R. Ott ,  Jonathan R. A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC: C07D495/04 ,  A61K31/519 ,  C07D495/14 ,  C07D495/20 ,  C07D519/00 ,  C07F7/08 ,  A61P35/02 ,  A61P35/04

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US09896446B2

公开(公告)日：2018-02-20

申请号：US14975605

申请日：2015-12-18

Applicant: IGNYTA, INC. ,  Cancer Research Technology Limited

Inventor： Henry J. Breslin ,  Bruce D. Dorsey ,  Benjamin J. Dugan ,  Robert L. Hudkins ,  Eugen F. Mesaros ,  Gregory R. Ott ,  Craig A. Zificsak ,  Allison L. Zulli ,  Ming Tao ,  Katherine M. Fowler ,  Emma L. Morris ,  Gregoire A. Pave ,  Jonathan R. A. Roffey ,  Nathaniel J. T. Monck ,  Christelle N. Soudy ,  Ikeoluwa Olowoye

IPC: A61K31/407 ,  C07D471/04 ,  C07D519/00 ,  C07D493/08 ,  C07D498/04 ,  C07F9/6584

CPC classification number: C07D471/04 ,  C07D493/08 ,  C07D498/04 ,  C07D519/00 ,  C07F9/6584

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative diseases.

公开(公告)号：US20160102094A1

公开(公告)日：2016-04-14

申请号：US14975605

申请日：2015-12-18

Applicant: Cancer Research Technology Limited ,  IGNYTA, INC.

Inventor： Henry J. Breslin ,  Bruce D. Dorsey ,  Benjamin J. Dugan ,  Robert L. Hudkins ,  Eugen F. Mesaros ,  Gregory R. Ott ,  Craig A. Zificsak ,  Allison L. Zulli ,  Ming Tao ,  Katherine M. Fowler ,  Emma L. Morris ,  Gregoire A. Pave ,  Jonathan R.A. Roffey ,  Nathaneil J.T. Monck ,  Christelle N. Soudy ,  Ikeoluwa Olowoye

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D493/08 ,  C07D498/04 ,  C07D519/00 ,  C07F9/6584

Abstract: The present application provides a compound of formula (1) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative diseases.

Abstract translation: 本申请提供式（1）化合物或其盐，其中R 7，R 8，R 9，G和X如本文所定义。 本申请进一步描述了包含该组合物的组合物。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。