公开(公告)号：US09834541B2

公开(公告)日：2017-12-05

申请号：US14437561

申请日：2013-10-02

Applicant: Merck Patent GmbH ,  CANCER RESEARCH TECHNOLOGY LIMITED

Inventor： Kai Schiemann ,  Frank Stieber ,  Julian Blagg ,  Aurelie Mallinger ,  Dennis Waalboer ,  Christian Rink ,  Simon Ross Crumpler

IPC: C07D471/10 ,  A61K31/444 ,  A61K31/4545 ,  C07D401/04 ,  C07D401/14 ,  A61K31/5377 ,  A61K31/499 ,  A61K31/4709 ,  C07D417/14 ,  C07D491/10 ,  C07D498/10

CPC classification number: C07D401/14 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/499 ,  A61K31/5377 ,  C07D401/04 ,  C07D417/14 ,  C07D471/10 ,  C07D491/10 ,  C07D498/10

Abstract: The invention provides novel substituted 2-aminopyridine compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.

公开(公告)号：US20140350015A1

公开(公告)日：2014-11-27

申请号：US14303448

申请日：2014-06-12

Applicant: Cancer Research Technology Limited

Inventor： Edward McDonald ,  Julian Blagg ,  Mark Pichowicz ,  Simon Ross Crumpler

IPC: C07D471/10 ,  C07D413/14 ,  C07D417/14 ,  C07D409/14 ,  C07D401/04 ,  C07D401/14

CPC classification number: C07D471/10 ,  C07D213/74 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to pyridine and pyrimidine based compounds, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and/or prevention of cancer.

Abstract translation: 本发明涉及基于吡啶和嘧啶的化合物，包含这些化合物的药物组合物及其作为用于治疗和/或预防癌症的治疗剂的潜在用途。

公开(公告)号：US09926319B2

公开(公告)日：2018-03-27

申请号：US15129338

申请日：2015-03-10

Applicant: MERCK PATENT GMBH ,  CANCER RESEARCH TECHNOLOGY LIMITED

Inventor： Kai Schiemann ,  Frank Stieber ,  Michel Calderini ,  Julian Blagg ,  Aurelie Mallinger ,  Dennis Waalboer ,  Christian Rink ,  Simon Ross Crumpler

IPC: A61P19/02 ,  A61P35/00 ,  C07D471/10 ,  A61K31/444 ,  A61P25/16 ,  C07D401/14 ,  C07D471/20 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/499 ,  A61K31/5377 ,  A61K45/06 ,  C07D417/14 ,  C07D498/10 ,  C07D519/00

CPC classification number: C07D471/20 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/499 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D417/14 ,  C07D471/10 ,  C07D498/10 ,  C07D519/00

Abstract: The invention provides novel substituted pyridyl piperidine compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.