专利检索 ap:("Cancer Research Technology Limited" OR "IGNYTA, INC.") AND inv:"Jonathan R.A. Roffey" 第 1 页

1.

发明申请
Azaquinazoline Inhibitors of Atypical Protein Kinase C 有权
标题翻译： Azaquinazoline非典型蛋白激酶C抑制剂

公开(公告)号：US20160102094A1

公开(公告)日：2016-04-14

申请号：US14975605

申请日：2015-12-18

申请人： Cancer Research Technology Limited , IGNYTA, INC.

发明人： Henry J. Breslin , Bruce D. Dorsey , Benjamin J. Dugan , Robert L. Hudkins , Eugen F. Mesaros , Gregory R. Ott , Craig A. Zificsak , Allison L. Zulli , Ming Tao , Katherine M. Fowler , Emma L. Morris , Gregoire A. Pave , Jonathan R.A. Roffey , Nathaneil J.T. Monck , Christelle N. Soudy , Ikeoluwa Olowoye

IPC分类号： C07D471/04

CPC分类号： C07D471/04 , C07D493/08 , C07D498/04 , C07D519/00 , C07F9/6584

摘要： The present application provides a compound of formula (1) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative diseases.

摘要翻译： 本申请提供式（1）化合物或其盐，其中R 7，R 8，R 9，G和X如本文所定义。本申请进一步描述了包含该组合物的组合物。式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。

2.

发明申请
Azaquinazoline Inhibitors Of Atypical Protein Kinase C 有权
标题翻译： Azaquinazoline抑制剂的非典型蛋白激酶C

公开(公告)号：US20150274720A1

公开(公告)日：2015-10-01

申请号：US14668022

申请日：2015-03-25

申请人： Ignyta, Inc. , Cancer Research Technology Limited

发明人： Bruce D. Dorsey , Benjamin J. Dugan , Katherine M. Fowler , Robert L. Hudkins , Eugen F. Mesaros , Nathaniel JT Monck , Emma L. Morris , Ikeoluwa Olowoye , Gregory R. Ott , Gregoire A. Pave , Jonathan R.A. Roffey , Christelle N. Soudy , Craig A. Zificsak , Allison L. Zulli

IPC分类号： C07D471/04 , C07D519/00

CPC分类号： C07D471/04 , A61P35/00 , A61P35/02 , A61P35/04 , C07D519/00

摘要： The present application provides a compound of formula (I) and/or a salt thereof, wherein R1, G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders. Compositions comprising a compound of Formula (I) and/or a salt thereof are also provided.

摘要翻译： 本申请提供式（I）化合物和/或其盐，其中R 1，G和X如本文所定义。式（I）化合物和/或其盐具有PKC抑制活性，可用于治疗增殖性疾病。还提供了包含式（I）化合物和/或其盐的组合物。

3.

发明申请
Thienopyrimidine Inhibitors of Atypical Protein Kinase C 有权
标题翻译：非典型蛋白激酶C的噻吩并嘧啶抑制剂

公开(公告)号：US20140323435A1

公开(公告)日：2014-10-30

申请号：US14285007

申请日：2014-05-22

申请人： Cancer Research Technology Limited , Cephalon, Inc.

发明人： Bruce D. Dorsey , Keith S. Learn , Emma L. Morris , Gregory R. Ott , Jonathan R.A. Roffey , Christelle N. Soudy , Jason C. Wagner

IPC分类号： C07D495/04 , C07D495/20 , C07F7/08 , C07D495/14

CPC分类号： C07D495/04 , C07D495/14 , C07D495/20 , C07D519/00 , C07F7/0812

摘要： The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

摘要翻译： 本申请提供式（I）化合物或其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，A，G，M，Q和X如本文所定义。式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。

4.

发明申请
THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C 审中-公开

公开(公告)号：US20170158706A1

公开(公告)日：2017-06-08

申请号：US15417191

申请日：2017-01-26

申请人： Cancer Research Technology Limited

发明人： Bruce D. Dorsey , Keith S. Learn , Emma L. Morris , Gregory R. Ott , Jonathan R.A. Roffey , Christelle N. Soudy , Jason C. Wagner

IPC分类号： C07D495/04 , C07D495/20 , C07D495/14 , C07D519/00

CPC分类号： C07D495/04 , C07D495/14 , C07D495/20 , C07D519/00 , C07F7/0812

摘要： The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.