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1.发明申请公开(公告)号：US20220218619A1
公开(公告)日：2022-07-14
申请号：US17604994
申请日：2020-06-11
申请人： Capsugel Belgium NV
发明人： Takahisa Takubo , Hitomi Doi , Kaori Sato
摘要： Problem to be solved: To provide a whitened or opacified capsule and film without using a white pigment such as titanium dioxide. Solution: A film, a capsule and a film-forming composition characterized by containing a film-forming polymer component selected from gelatin and pullulan and an opacifying agent consisting of a water-soluble salt except calcium salt carbonate and bicarbonate, wherein the salt is selected from a sodium salt, potassium salt, an ammonium salt and a magnesium salt.
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公开(公告)号：US20210275404A1
公开(公告)日：2021-09-09
申请号：US17253103
申请日：2019-07-03
申请人： Capsugel Belgium NV
发明人： Kaori Sato , Takahisa Takubo , Hitomi Doi
摘要： [Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.
[Solution] Provided is a film, a capsule, and a film forming composition, characterized by comprising: a film-forming polymer; and a whitening agent including either a surfactant or both a surfactant and a salt, and characterized in that the surfactant is selected from a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and a saponin.-
公开(公告)号：US20180256506A1
公开(公告)日：2018-09-13
申请号：US15976622
申请日：2018-05-10
申请人： Capsugel Belgium NV
IPC分类号： A61K9/48
CPC分类号： A61K9/4816
摘要： Publicly available pullulan hard capsule shells present certain drawbacks, notably a non fully satisfactory shell mechanical strength (i.e. shell brittleness) at shell low LOD. Improving this property is a particularly desirable goal for pullulan hard capsule shells. The present invention solves this and other objects by providing new hard pullulan capsule shells and capsules comprising (I) moisture, (II) a mono-, di-, and oligosaccharides free pullulan and (III) a setting system. Also provided are an aqueous composition and a dip-molding manufacturing method for the manufacture of such shells and capsules.
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4.发明公开公开(公告)号：US20240058225A1
公开(公告)日：2024-02-22
申请号：US18371163
申请日：2023-09-21
申请人： Capsugel Belgium NV
发明人： Kaori Sato , Takahisa Takubo , Hitomi Doi
CPC分类号： A61K8/0204 , A61K8/11 , A61K8/37 , A61K8/46 , A61K8/65 , A61K8/731 , A61K8/86 , A61K2800/10 , A61K2800/26 , A61K2800/43 , A61K2800/594 , A61K2800/92
摘要： [Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.
[Solution] Provided is a film, a capsule, and a film forming composition, characterized by comprising: a film-forming polymer; and a whitening agent including either a surfactant or both a surfactant and a salt, and characterized in that the surfactant is selected from a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and a saponin.-
公开(公告)号：US20150140084A1
公开(公告)日：2015-05-21
申请号：US14402669
申请日：2013-05-20
申请人： Capsugel Belgium NV
发明人： Takahisa Takubo
CPC分类号： A61K9/4833 , A23L33/10 , A23V2002/00 , A61K9/4858 , A61K9/4866 , A61K9/4883 , A61K9/4891 , A61K31/167 , A61K47/10 , A61K47/46
摘要： The present disclosure relates to acid resistant banding solutions for two piece hard capsules, and methods of making the same. The present disclosure also relates, in part, to a method for banding such capsules which provides an acid resistant seal between the capsule parts and achieves an increased acid resistance in vitro. The instant disclosure further relates to a capsule sealing solution formula that comprises shellac ink or shellac ink vehicle component.
摘要翻译： 本公开内容涉及用于两片硬胶囊的耐酸性条带溶液及其制备方法。 本公开还部分涉及用于将这种胶囊捆扎的方法，其在胶囊部件之间提供耐酸密封并且在体外实现增加的耐酸性。 本公开进一步涉及胶囊密封溶液配方，其包含虫胶油墨或虫胶油墨载体组分。
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6.发明公开公开(公告)号：US20240299259A1
公开(公告)日：2024-09-12
申请号：US18667925
申请日：2024-05-17
申请人： Capsugel Belgium NV
发明人： Kaori Sato , Takahisa Takubo , Hitomi Doi
CPC分类号： A61K8/0204 , A61K8/11 , A61K8/37 , A61K8/46 , A61K8/65 , A61K8/731 , A61K8/86 , A61K2800/10 , A61K2800/26 , A61K2800/43 , A61K2800/594 , A61K2800/92
摘要： [Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.
[Solution] Provided is a film, a capsule, and a film forming composition, characterized by comprising: a film-forming polymer; and a whitening agent including either a surfactant or both a surfactant and a salt, and characterized in that the surfactant is selected from a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and a saponin.-
公开(公告)号：US11878079B2
公开(公告)日：2024-01-23
申请号：US18145463
申请日：2022-12-22
申请人： Capsugel Belgium NV
CPC分类号： A61K9/4816 , A61K47/36
摘要： The instant disclosure provides a capsule composition comprising pullulan, a setting system and a surfactant system that is a sucroglyceride or a sugar fatty acid ester, and methods for making such capsules.
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公开(公告)号：US20220008296A1
公开(公告)日：2022-01-13
申请号：US17486739
申请日：2021-09-27
申请人： Capsugel Belgium NV
发明人： Keith Hutchison , Takahisa Takubo
摘要： [Technical Problem] A problem of the present invention is, in one aspect, to provide a capsule formulation including an active ingredient and the like that may deteriorate upon contacting an acid, wherein the capsule formulation makes it possible not to deteriorate the active ingredient and the like by a gastric acid which enters into a capsule film.
[Technical Solution] A capsule formulation comprising an active ingredient and oil, wherein said capsule of said formulation is an enteric capsule comprising a water soluble film forming polymer and gellan gum; said oil is an oil acceptable for pharmaceuticals or foods; and said active ingredient is encapsulated in said capsule together with said oil, and the production method thereof, are provided.-
公开(公告)号：US20160015651A1
公开(公告)日：2016-01-21
申请号：US14771161
申请日：2014-03-03
申请人： CAPSUGEL BELGIUM NV
发明人： Takahisa Takubo
CPC分类号： A61K9/4875 , A23L33/00 , A23P10/30 , A61K9/4858 , A61K9/4866 , A61K35/50 , A61K38/164 , A61K38/43 , A61K38/482 , C12Y304/21062
摘要： A problem of the present disclosure is, in one embodiment, to create a hard capsule formulation that includes a pharmaceutical agent or the like whose components deteriorate upon contact with an acid, in which the pharmaceutical agent or the like does not deteriorate due to gastric acid penetrating into the outer shell of the hard capsule. A hard capsule formulation comprising a hard capsule with acid resistance, in which the hard capsule is not treated with enteric coating, and the hard capsule formulation comprises an agent to inhibit invasion of gastric fluid and a pharmaceutical agent in the hard capsule.
摘要翻译： 在一个实施方案中，本发明的一个问题是产生一种硬胶囊制剂，其包括与酸接触时其组分劣化的药剂等，其中药剂等不会由于胃酸而劣化 渗入硬胶囊的外壳。 一种硬胶囊制剂，其包含具有耐酸性的硬胶囊，其中所述硬胶囊不经肠溶包衣处理，并且所述硬胶囊制剂包含抑制胃液侵入的药剂和硬胶囊中的药剂。
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10.发明授权公开(公告)号：US11801205B2
公开(公告)日：2023-10-31
申请号：US17253103
申请日：2019-07-03
申请人： Capsugel Belgium NV
发明人： Kaori Sato , Takahisa Takubo , Hitomi Doi
CPC分类号： A61K8/0204 , A61K8/11 , A61K8/37 , A61K8/46 , A61K8/65 , A61K8/731 , A61K8/86 , A61K2800/10 , A61K2800/26 , A61K2800/43 , A61K2800/594 , A61K2800/92
摘要： [Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.
[Solution] Provided is a film, a capsule, and a film forming composition, characterized by comprising: a film-forming polymer; and a whitening agent including either a surfactant or both a surfactant and a salt, and characterized in that the surfactant is selected from a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and a saponin.
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