公开(公告)号：US20180257864A1

公开(公告)日：2018-09-13

申请号：US15941274

申请日：2018-03-30

申请人： Cargill Incorporated

发明人： Catherine Asleson Dundon ,  Pirrko Suominen ,  Aristos Aristidou ,  Brian J. Rush ,  Kari Koivuranta ,  Benjamin Matthew Hause ,  Thomas William McMullin ,  Kevin Roberg-Perez

IPC分类号： B65G15/12 ,  B65G17/12 ,  E01B29/32

CPC分类号： B65G15/12 ,  B65G17/12 ,  C12N15/52 ,  C12P7/06 ,  C12P7/40 ,  C12P7/56 ,  E01B29/32 ,  Y02E50/17 ,  Y10T137/85986

摘要： Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.

公开(公告)号：US20210155411A1

公开(公告)日：2021-05-27

申请号：US17154190

申请日：2021-01-21

申请人： Cargill, Incorporated

发明人： Catherine Asleson DUNDON ,  Pirrko Suominen ,  Aristos Aristidou ,  Brian J. Rush ,  Kari Koivuranta ,  Benjamin Matthew Hause ,  Thomas William McMullin ,  Kevin Roberg-Perez

IPC分类号： B65G15/12 ,  C12P7/06 ,  C12P7/40 ,  C12N15/52 ,  C12P7/56 ,  B65G17/12 ,  E01B29/32

摘要： Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.

公开(公告)号：US10899544B2

公开(公告)日：2021-01-26

申请号：US15941274

申请日：2018-03-30

申请人： Cargill Incorporated

发明人： Catherine Asleson Dundon ,  Pirrko Suominen ,  Aristos Aristidou ,  Brian J. Rush ,  Kari Koivuranta ,  Benjamin Matthew Hause ,  Thomas William McMullin ,  Kevin Roberg-Perez

IPC分类号： C12P7/06 ,  C12P7/40 ,  C12N15/52 ,  C12P7/56 ,  B65G15/12 ,  B65G17/12 ,  E01B29/32

摘要： Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.

公开(公告)号：US20200377302A9

公开(公告)日：2020-12-03

申请号：US15941274

申请日：2018-03-30

申请人： Cargill Incorporated

发明人： Catherine Asleson Dundon ,  Pirrko Suominen ,  Aristos Aristidou ,  Brian J. Rush ,  Kari Koivuranta ,  Benjamin Matthew Hause ,  Thomas William McMullin ,  Kevin Roberg-Perez

IPC分类号： B65G15/12 ,  B65G17/12 ,  E01B29/32

摘要： Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.

公开(公告)号：US20150315616A1

公开(公告)日：2015-11-05

申请号：US14720899

申请日：2015-05-25

申请人： Cargill Incorporated

发明人： Catherine Asleson Dundon ,  Pirrko Suominen ,  Aristos Aristidou ,  Brian J. Rush ,  Kari Koivuranta ,  Benjamin Matthew Hause ,  Thomas William McMullin ,  Kevin Roberg-Perez

IPC分类号： C12P7/56 ,  C12P7/40 ,  C12P7/06

CPC分类号： B65G15/12 ,  B65G17/12 ,  C12N15/52 ,  C12P7/06 ,  C12P7/40 ,  C12P7/56 ,  E01B29/32 ,  Y02E50/17 ,  Y10T137/85986

摘要： Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyveromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.

摘要翻译： 酵母细胞被遗传修饰以破坏从二羟丙酮到甘油的天然代谢途径。 在某些方面，酵母细胞是克鲁维酵母属，假丝酵母​​属或发chen类。 在其它方面，酵母细胞能够产生至少一种有机酸，如乳酸盐。 酵母细胞比野生型菌株产生明显较少的甘油，并且通常产生更高产量的所需发酵产物。 本发明的酵母细胞在培养时经常生长良好，尽管它们的甘油产量减少。