公开(公告)号：US11965201B2

公开(公告)日：2024-04-23

申请号：US17203617

申请日：2021-03-16

申请人： LanzaTech NZ, Inc.

发明人： Kaspar Valgepea ,  Michael Koepke ,  James Bruce Yarnton Haycock Behrendorff ,  Esteban Marcellin ,  Lars K. Nielsen ,  Renato de S. P. Lemgruber

IPC分类号： C12P7/56 ,  C12N1/20 ,  C12N1/38 ,  C12N9/06 ,  C12N9/10 ,  C12N9/12 ,  C12N9/78 ,  C12N9/90 ,  C12N15/52 ,  C12P7/04 ,  C12P7/06 ,  C12P7/18 ,  C12P7/40 ,  C12P7/54

CPC分类号： C12P7/56 ,  C12N1/20 ,  C12N1/38 ,  C12N9/0016 ,  C12N9/1018 ,  C12N9/1029 ,  C12N9/1217 ,  C12N9/78 ,  C12N9/90 ,  C12N15/52 ,  C12P7/04 ,  C12P7/065 ,  C12P7/18 ,  C12P7/40 ,  C12P7/54 ,  C12Y104/01012 ,  C12Y201/03003 ,  C12Y207/02002 ,  C12Y305/03006 ,  C12Y501/01012 ,  C12Y504/03005 ,  Y02E50/10

摘要： The invention provides methods for improving efficiency of fermentation by arginine supplementation, and genetically modified bacterium for use therefor. More particularly the invention provides methods for (i) increasing the production ATP intensive products with arginine supplementation, (ii) increasing utilization of arginine by a C1-fixing bacterium; and (iii) providing C1-fixing bacterium with optimized arginine de-aminase pathways.

公开(公告)号：US11959065B2

公开(公告)日：2024-04-16

申请号：US17836261

申请日：2022-06-09

申请人： Pro Farm Group, Inc.

发明人： Ratnakar Asolkar ,  Ana Lucia Cordova-Kreylos ,  Margarita Rodriguez ,  Carly Todd ,  Debora Wilk ,  Pamela G. Marrone

IPC分类号： C12N1/20 ,  A01N37/10 ,  A01N63/22 ,  A01P5/00 ,  C12P7/40 ,  C12R1/11

CPC分类号： C12N1/20 ,  A01N37/10 ,  A01N63/22 ,  A01P5/00 ,  C12N1/205 ,  C12P7/40 ,  C12R2001/11 ,  A01N37/10 ,  A01N2300/00

摘要： Provided are bioactive compositions and metabolites derived from Bacillus and particularly Bacillus megaterium cultures responsible for controlling pests as well as their methods of use for controlling pests. Further provided are pesticidal Bacillus megaterium strains.

公开(公告)号：US20240117389A1

公开(公告)日：2024-04-11

申请号：US18470284

申请日：2023-09-19

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Youngsoon UM ,  Deurim YUN ,  Sun Mi LEE ,  Gyeongtaek GONG ,  Ja Kyong KO ,  Jung Ho AHN

IPC分类号： C12P7/40 ,  C12P7/02 ,  C12P7/16 ,  C12P7/52

CPC分类号： C12P7/40 ,  C12P7/02 ,  C12P7/16 ,  C12P7/52

摘要： The present disclosure is to provide a method capable of producing an organic acid in high yield from an acetic acid strain using synthesis gas as a substrate. According to the present disclosure, the productivity of metabolites with C2 to C6 carbon atoms derived from synthesis gas and the selectivity of hexanoic acid production among metabolites can be improved through a first fermentation step of simultaneously providing a substrate comprising synthesis gas and sugar; and a second fermentation step of semi-mixotrophic fermentation of providing only the substrate comprising the synthesis gas. Therefore, the disclosure can contribute to sustainable chemical production using synthesis gas.

公开(公告)号：US11753660B2

公开(公告)日：2023-09-12

申请号：US17506130

申请日：2021-10-20

申请人： Mitsubishi Chemical UK Limited

发明人： Graham Ronald Eastham ,  Gill Stephens ,  Andrew Yiakoumetti

IPC分类号： C12P7/40 ,  C07C67/00 ,  C08F120/06 ,  C08F120/14 ,  C12N9/02 ,  C12N9/16 ,  C12P5/02 ,  C12P7/62 ,  C12N9/10

CPC分类号： C12P7/40 ,  C07C67/00 ,  C08F120/06 ,  C08F120/14 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/16 ,  C12P5/026 ,  C12P7/62 ,  C12Y103/03006 ,  C12Y203/01084 ,  C12Y301/02023 ,  Y02E50/30

摘要： A process of producing methacrylic acid and/or derivatives thereof including the following steps: (a) biologically converting isobutyryl-CoA into methacrylyl-CoA by the action of an oxidase; and (b) converting methacrylyl-CoA into methacrylic acid and/or derivatives thereof. The invention also extends to microorganisms adapted to conduct the steps of the process.

公开(公告)号：US11718864B2

公开(公告)日：2023-08-08

申请号：US16917099

申请日：2020-06-30

申请人： PFIZER INC.

发明人： Gregory Walter Hiller ,  Jeffrey Joseph Mitchell ,  Bhanu Chandra Mulukutla ,  Pamela Mary Pegman

IPC分类号： C12N15/62 ,  C12P7/62 ,  C12P7/42 ,  C12P7/52 ,  C07K16/00 ,  C12P7/56 ,  C12P7/40 ,  C12P17/18

CPC分类号： C12P7/62 ,  C07K16/00 ,  C12P7/40 ,  C12P7/42 ,  C12P7/52 ,  C12P7/56 ,  C12P17/182 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2511/00

摘要： The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in fed-batch culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.

公开(公告)号：US11684067B2

公开(公告)日：2023-06-27

申请号：US16949008

申请日：2020-10-09

申请人： ECOLAB USA INC.

发明人： Junzhong Li ,  Allison Brewster ,  Richard Staub ,  Steven J. Lange ,  Taz Cheritu ,  Jonathan P. Fast ,  Catherine Hanson

IPC分类号： A01N37/16 ,  C07C407/00 ,  C11D3/00 ,  C12P7/40 ,  C11D3/39 ,  C11D3/48 ,  C07C409/24 ,  A01N37/00 ,  A61L2/00 ,  A61L2/16 ,  A61K8/38 ,  A61Q17/00

CPC分类号： A01N37/16 ,  A01N37/00 ,  A61K8/38 ,  A61L2/00 ,  A61L2/16 ,  A61Q17/005 ,  C07C407/00 ,  C07C409/24 ,  C11D3/00 ,  C11D3/3947 ,  C11D3/48 ,  C12P7/40 ,  C07C407/00 ,  C07C409/24 ,  A01N37/16 ,  A01N59/00

摘要： The present invention relates generally to peroxyformic acid forming compositions, methods for forming peroxyformic acid, preferably in situ, using the peroxyformic acid forming compositions. The present invention also relates to the peroxyformic acid formed by the above compositions and methods. The present invention further relates to the uses of the peroxyformic acid, preferably in situ, for treating a surface or a target. The present invention further relates to methods for treating a biofilm using peroxyformic acid, including peroxyformic acid generated in situ.

公开(公告)号：US20190233863A1

公开(公告)日：2019-08-01

申请号：US16377037

申请日：2019-04-05

申请人： XYLECO, INC.

发明人： Marshall MEDOFF ,  Thomas Craig MASTERMAN ,  James LYNCH

IPC分类号： C12P19/14 ,  C12P19/04 ,  C12N9/42 ,  C12P19/12 ,  C12P7/10 ,  C12P5/02 ,  C12P7/04 ,  C12P7/16 ,  C12P7/24 ,  C12P7/28 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/48 ,  C12P7/52 ,  C12P7/56 ,  C12P7/62 ,  C12P19/02

CPC分类号： C12P19/14 ,  C12N9/2434 ,  C12N9/2437 ,  C12P5/02 ,  C12P5/023 ,  C12P7/04 ,  C12P7/10 ,  C12P7/16 ,  C12P7/24 ,  C12P7/28 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/48 ,  C12P7/52 ,  C12P7/56 ,  C12P7/62 ,  C12P19/02 ,  C12P19/04 ,  C12P19/12 ,  C12P2201/00 ,  C12Y302/01004 ,  Y02E50/16 ,  Y02E50/17 ,  Y02E50/343

摘要： Provided herein are methods for processing biomass materials that are disposed in one or more structures or carriers, e.g., a bag, a shell, a net, a membrane, a mesh or any combination of these. Containing the material in this manner allows it to be readily added or removed at any point and in any sequence during processing.

公开(公告)号：US20190218505A1

公开(公告)日：2019-07-18

申请号：US16327695

申请日：2017-08-23

申请人： Eleftherios T. Papoutsakis ,  Kamil Charubin ,  Alexander A. Mitkas

发明人： Eleftherios T. Papoutsakis ,  Kamil Charubin ,  Alexander A. Mitkas

IPC分类号： C12N1/20 ,  C12P7/14 ,  C12P1/04

CPC分类号： C12N1/20 ,  C12P1/04 ,  C12P7/04 ,  C12P7/065 ,  C12P7/10 ,  C12P7/14 ,  C12P7/16 ,  C12P7/28 ,  C12P7/40 ,  C12P39/00 ,  C12P2203/00 ,  Y02E50/17

摘要： Syntrophic co-cultures containing at least two microorganisms, wherein (a) at least one of the microorganisms is a solventogen able to metabolize biomass to produce metabolic byproduct(s) therefrom, (b) at least one of the microorganisms is a microorganism different from the solventogen, wherein the microorganism different from the primary solventogen depends on the metabolites and/or the metabolism of the primary solventogen for survival and growth and is able to fix or metabolize the metabolic byproducts produced by the solventogen to produce metabolic byproduct(s) therefrom, and (c) the solventogen is able to metabolize the metabolic byproduct(s) produced by the microorganism different from the solventogen to produce further metabolic byproducts, such as liquid fuels and commodity chemicals, as well as methods for using these syntrophic co-cultures to produce such products via fermentation, are disclosed.

公开(公告)号：US20190194029A1

公开(公告)日：2019-06-27

申请号：US16068989

申请日：2017-01-19

申请人： PURAC BIOCHEM BV

发明人： Johannes Jeichienus DE VRIES ,  Raymon FREDIANSYAH

IPC分类号： C01F5/30 ,  C01F5/10 ,  C01B7/03 ,  B01D1/26 ,  B01D1/28 ,  C12P7/52 ,  C07C51/02 ,  C12P7/48 ,  C12P7/44 ,  C12P7/40 ,  C12P7/56 ,  C12P17/04 ,  C12P7/42 ,  C12P7/46

CPC分类号： C01F5/30 ,  B01D1/26 ,  B01D1/28 ,  C01B7/035 ,  C01F5/10 ,  C07C51/02 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P7/48 ,  C12P7/52 ,  C12P7/56 ,  C12P17/04 ,  C07C55/10 ,  C07C59/08 ,  C07C59/06 ,  C07C59/01

摘要： Magnesium chloride solutions including providing aqueous magnesium chloride solution with magnesium chloride concentration of 10-30 wt. % to concentration step where water is evaporated, resulting in concentrated magnesium chloride solution with magnesium chloride concentration of 30-50 wt. %, wherein concentration step is carried out in one or more stages, wherein at least one of the stages is conducted at elevated pressure, withdrawing concentrated magnesium chloride solution from concentration step, and providing it to thermohydrolysis reactor of at least 300° C., withdrawing MgO from thermohydrolysis reactor in solid form, and withdrawing a HCl containing gas stream of at least 300° C. from thermohydrolysis reactor, providing the HCl-containing gas stream of at least 300° C. to cooling step, where HCl-containing gas stream is contacted with cooling liquid, withdrawing HCl-containing gas stream below 150° C. from cooling step, circulating cooling liquid through heat exchanger where energy is transferred to heating liquid which circulates from heat exchanger to concentration step.

公开(公告)号：US20190153553A1

公开(公告)日：2019-05-23

申请号：US16194923

申请日：2018-11-19

申请人： University of Massachusetts

发明人： Derek R. LOVLEY ,  Toshiyuki UEKI ,  Kelly N. LOVLEY

IPC分类号： C12R1/01 ,  C12P7/40 ,  C12P5/00 ,  C12M1/42

CPC分类号： C12R1/01 ,  C12M21/12 ,  C12M29/04 ,  C12M35/02 ,  C12N9/0006 ,  C12N9/1025 ,  C12P5/00 ,  C12P7/065 ,  C12P7/40

摘要： A genetically engineered strain of Geobacter sulfurreducens exhibits improved function as a cathode biofilm compared to the wild type strain. The genetically engineered Geobacter sulfurreducens strain is capable of using carbon dioxide as a carbon source and electrical current as an energy source for producing a carbonaceous chemical using a reverse tricarboxylic acid pathway.