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公开(公告)号：US20180066262A1
公开(公告)日：2018-03-08
申请号：US15557010
申请日：2016-03-09
申请人： Caris Science, Inc.
发明人： Valeriy DOMENYUK , Adam STARK , Nianqing XIAO , Zhenyu ZHONG , Mark MIGLARESE , David SPETZLER
IPC分类号： C12N15/115 , C12Q1/68 , C40B20/08 , G01N33/50
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/3519 , C12N2320/10 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C40B20/08 , G01N33/5005
摘要： Methods and compositions are provided for oligonucleotide probes and oligonucleotide probe libraries that recognize targets of interest. The targets include circulating biomarkers such as microvesicles, including those derived from various diseases.
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公开(公告)号：US20190310172A1
公开(公告)日：2019-10-10
申请号：US16376851
申请日：2019-04-05
申请人： Caris Science, Inc.
发明人： Zhenyu ZHONG , David SPETZLER
摘要： Methods and compositions are provided for enriching extracellular vesicles, e.g., from bodily fluids. The vesicles may be indicative of various diseases. Vesicle characterization can be used for diagnostic, theranostic and other purposes.
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公开(公告)号：US20180268937A1
公开(公告)日：2018-09-20
申请号：US15762932
申请日：2016-09-24
申请人： Caris Science, Inc.
发明人： David SPETZLER , Quanyuan HE , Nianqing XIAO
IPC分类号： G16H50/20 , G06F3/0484 , G16H50/70 , G16H10/40
CPC分类号： G16H50/20 , G06F3/0484 , G06F3/04842 , G06F16/00 , G06T11/206 , G06T11/60 , G16B20/00 , G16B45/00 , G16H10/40 , G16H50/70
摘要： A method, apparatus, and computer program product for analyzing biological data with an application that provides a graphical user interface are disclosed. A method in accordance with the disclosure may include receiving patient data associated with various patient attributes, determining an interrelationship between any one of those attributes, performing a therapeutic regime analysis, and displaying at least one graphical user interface. The method may further include assisting in providing patient care based on the interrelationships displayed on the graphical user interface. Patient attributes may include biomarker status that corresponds with the expression, sequence, or other state, of various biomarkers. The method, apparatus, and computer program product are useful for analyzing molecular profiling data.
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公开(公告)号：US20200270610A1
公开(公告)日：2020-08-27
申请号：US16694851
申请日：2019-11-25
申请人： Caris Science, Inc.
发明人： Valeriy DOMENYUK , Adam STARK , Nianqing XIAO , Zhenyu ZHONG , Mark MIGLARESE , David SPETZLER
IPC分类号： C12N15/115 , C12Q1/6886 , C40B20/08 , G01N33/50
摘要： Methods and compositions are provided for oligonucleotide probes and oligonucleotide probe libraries that recognize targets of interest. The targets include circulating biomarkers such as microvesicles, including those derived from various diseases.
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公开(公告)号：US20190078093A1
公开(公告)日：2019-03-14
申请号：US16084504
申请日：2017-03-18
申请人： Caris Science, Inc.
IPC分类号： C12N15/115 , C12N15/10 , C12Q1/6883
摘要： Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.
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公开(公告)号：US20170356903A1
公开(公告)日：2017-12-14
申请号：US15528417
申请日：2015-11-23
申请人： Caris Science, Inc.
IPC分类号： G01N33/53 , C12Q1/68 , C12N15/113 , G01N33/574 , G01N33/564 , G01N33/68 , C12N15/115
CPC分类号： G01N33/5308 , C12N15/113 , C12N15/115 , C12N2310/113 , C12N2310/16 , C12N2320/10 , C12Q1/34 , C12Q1/6876 , C12Q1/6883 , C12Q1/6886 , C12Q2600/178 , G01N33/564 , G01N33/574 , G01N33/6893 , G01N33/6896 , G01N2333/922 , Y02A50/58
摘要： Methods and compositions are provided to identify oligonucleotide probes that can detect various targets of interest. The targets include microvesicles, microvesicle antigens, and nucleic acids. The target detection may be used to provide a diagnosis, prognosis or theranosis of a medical condition, a disease or a disorder.
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公开(公告)号：US20160069889A1
公开(公告)日：2016-03-10
申请号：US14652728
申请日：2013-12-19
申请人： CARIS SCIENCE, INC.
IPC分类号： G01N33/574 , G01N33/53 , C12N15/10
CPC分类号： G01N33/57488 , C12N15/1048 , C12Q1/6811 , C12Q1/6886 , G01N33/5076 , G01N33/5308 , C12Q2525/205
摘要： Methods are provided for selecting aptamers that are specific to a target of interest from amongst a library of potential aptamer sequences. Aptamers disclosed can be used to detect and/or characterize biological entities of interest, e.g. microvesicles and/or surface antigens. Further disclosed are biomarkers that can be used for diagnosing different disorders including different types of cancer.
摘要翻译： 提供了从潜在的适配子序列库中选择特异于目的靶标的适体的方法。 所公开的适配子可用于检测和/或表征感兴趣的生物实体，例如， 微泡和/或表面抗原。 进一步公开的是可用于诊断不同类型癌症的不同疾病的生物标志物。
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