公开(公告)号：US20050154536A1

公开(公告)日：2005-07-14

申请号：US10925862

申请日：2004-08-25

申请人： Carson Chow ,  Yoram Vodovotz ,  Gilles Clermont ,  Mitchell Fink ,  John Bartels ,  Steven Chang

发明人： Carson Chow ,  Yoram Vodovotz ,  Gilles Clermont ,  Mitchell Fink ,  John Bartels ,  Steven Chang

IPC分类号： A61B20060101 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

CPC分类号： G01N33/5091 ,  G16B5/00 ,  G16C20/30

摘要： A mathematical prognostic in which changes in a number of physiologically significant factors are measured and interpolated to determine a “damage fluction” incident to bacterial infection or other serious inflammation, followed by either or both of in vitro or in vivo investigations of a particular active agent (drug) and adjustment of the model so as better to evaluate the particular active agent. By measuring a large number of physiologically significant factors including, but not limited to, Interleukin 6 (IL-6), Interleukin 10 (IL-10), Nitric Oxide (NO), and others, it is possible to predict life versus death by the damage function, dD/dt. To evaluate one or more drug candidates against inflammation, the mathematical model is applied first, followed by in vivo and/or in vitro investigations, and the in vivo and/or in vitro investigations are in turn used to adjust or to enhance, if applicable, the mathematical model as it is applied to the particular drug candidate.

摘要翻译： 一种数学预测，其中测量和内插多个生理学重要因素的变化以确定对细菌感染或其他严重炎症的“损伤流感”事件，随后是特定活性剂的体外或体内研究中的任一个或两者 （药物）和模型的调整，以便更好地评估特定的活性剂。 通过测量大量的生理学显着因子，包括但不限于白细胞介素6（IL-6），白细胞介素10（IL-10），一氧化氮（NO）等），可以预测寿命与死亡 损伤函数dD / dt。 为了评估一种或多种抗炎症候选药物，首先应用数学模型，然后进行体内和/或体外研究，并且如果适用，体内和/或体外研究又被用于调节或增强 ，它被应用于特定药物候选人的数学模型。