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公开(公告)号：US20050154536A1
公开(公告)日：2005-07-14
申请号：US10925862
申请日：2004-08-25
申请人： Carson Chow , Yoram Vodovotz , Gilles Clermont , Mitchell Fink , John Bartels , Steven Chang
发明人： Carson Chow , Yoram Vodovotz , Gilles Clermont , Mitchell Fink , John Bartels , Steven Chang
IPC分类号： A61B20060101 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G01N33/5091 , G16B5/00 , G16C20/30
摘要： A mathematical prognostic in which changes in a number of physiologically significant factors are measured and interpolated to determine a “damage fluction” incident to bacterial infection or other serious inflammation, followed by either or both of in vitro or in vivo investigations of a particular active agent (drug) and adjustment of the model so as better to evaluate the particular active agent. By measuring a large number of physiologically significant factors including, but not limited to, Interleukin 6 (IL-6), Interleukin 10 (IL-10), Nitric Oxide (NO), and others, it is possible to predict life versus death by the damage function, dD/dt. To evaluate one or more drug candidates against inflammation, the mathematical model is applied first, followed by in vivo and/or in vitro investigations, and the in vivo and/or in vitro investigations are in turn used to adjust or to enhance, if applicable, the mathematical model as it is applied to the particular drug candidate.
摘要翻译： 一种数学预测，其中测量和内插多个生理学重要因素的变化以确定对细菌感染或其他严重炎症的“损伤流感”事件，随后是特定活性剂的体外或体内研究中的任一个或两者 （药物）和模型的调整，以便更好地评估特定的活性剂。 通过测量大量的生理学显着因子，包括但不限于白细胞介素6（IL-6），白细胞介素10（IL-10），一氧化氮（NO）等），可以预测寿命与死亡 损伤函数dD / dt。 为了评估一种或多种抗炎症候选药物，首先应用数学模型，然后进行体内和/或体外研究，并且如果适用，体内和/或体外研究又被用于调节或增强 ，它被应用于特定药物候选人的数学模型。
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公开(公告)号：US08630810B2
公开(公告)日：2014-01-14
申请号：US13423714
申请日：2012-03-19
申请人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
发明人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
摘要： Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.
摘要翻译： 提供了模拟组织愈合的方法。 该方法包括使用炎症，组织损伤或功能障碍和组织愈合的相关作用的机械计算机模型来预测受损组织在体内愈合的结果，从而预测受损组织在体内愈合的结果。 还提供了在计算设备上实现这些方法。 根据本文所述的方法适于模拟的疾病和/或病症的非限制性实例包括：糖尿病，糖尿病足溃疡，坏死性小肠结肠炎，溃疡性结肠炎，克罗恩病，炎性肠病，再狭窄（血管成形术或支架后 植入），切口伤口，切除伤口，手术，意外创伤，压力性溃疡，淤滞性溃疡，腱断裂，声带折叠，中耳炎和胰腺炎。
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公开(公告)号：US20120271611A1
公开(公告)日：2012-10-25
申请号：US13423714
申请日：2012-03-19
申请人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
发明人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
IPC分类号： G06G7/60
摘要： Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.
摘要翻译： 提供了模拟组织愈合的方法。 该方法包括使用炎症，组织损伤或功能障碍和组织愈合的相关作用的机械计算机模型来预测受损组织在体内愈合的结果，从而预测受损组织在体内愈合的结果。 还提供了在计算设备上实现这些方法。 根据本文所述的方法适于模拟的疾病和/或病症的非限制性实例包括：糖尿病，糖尿病足溃疡，坏死性小肠结肠炎，溃疡性结肠炎，克罗恩病，炎性肠病，再狭窄（血管成形术或支架后 植入），切口伤口，切除伤口，手术，意外创伤，压力性溃疡，淤滞性溃疡，腱断裂，声带折叠，中耳炎和胰腺炎。
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公开(公告)号：US08165819B2
公开(公告)日：2012-04-24
申请号：US11869852
申请日：2007-10-10
申请人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
发明人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
摘要： Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.
摘要翻译： 提供了模拟组织愈合的方法。 该方法包括使用炎症，组织损伤或功能障碍和组织愈合的相关作用的机械计算机模型来预测受损组织在体内愈合的结果，从而预测受损组织在体内愈合的结果。 还提供了在计算设备上实现这些方法。 根据本文所述的方法适于模拟的疾病和/或病症的非限制性实例包括：糖尿病，糖尿病足溃疡，坏死性小肠结肠炎，溃疡性结肠炎，克罗恩病，炎性肠病，再狭窄（血管成形术或支架后 植入），切口伤口，切除伤口，手术，意外创伤，压力性溃疡，淤滞性溃疡，腱断裂，声带折叠，中耳炎和胰腺炎。
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公开(公告)号：US20080228456A1
公开(公告)日：2008-09-18
申请号：US11869852
申请日：2007-10-10
申请人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
发明人： Gilles Clermont , Patricia A. Hebda , Yee Key Li , Qi Mi , David L. Steed , Joshua Thomas Sullivan , Katherine Verdolini Abbott , Yoram Vodovotz , Ivan Petrov Yotov , Gary An
摘要： Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.
摘要翻译： 提供了模拟组织愈合的方法。 该方法包括使用炎症，组织损伤或功能障碍和组织愈合的相关作用的机械计算机模型来预测受损组织在体内愈合的结果，从而预测受损组织在体内愈合的结果。 还提供了在计算设备上实现这些方法。 根据本文所述的方法适于模拟的疾病和/或病症的非限制性实例包括：糖尿病，糖尿病足溃疡，坏死性小肠结肠炎，溃疡性结肠炎，克罗恩病，炎性肠病，再狭窄（血管成形术或支架后 植入），切口伤口，切除伤口，手术，意外创伤，压力性溃疡，淤滞性溃疡，腱断裂，声带折叠，中耳炎和胰腺炎。
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6.发明申请Diagnostic And Therapeutic Uses Of Augmenter Of Liver Regeneration In Inflammatory Conditions 审中-公开肝脏再生增强剂在炎症条件下的诊断和治疗用途公开(公告)号：US20090208513A1
公开(公告)日：2009-08-20
申请号：US12205417
申请日：2008-09-05
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/53 , A61P29/00
CPC分类号： G01N33/573 , A01K2207/20 , A01K2207/30 , A01K2227/105 , A01K2267/0337 , A61K31/00 , C07K16/18 , C07K16/22 , C12N15/113 , C12N2310/11 , G01N33/6893 , G01N2333/71 , G01N2333/90212 , G01N2800/24 , G01N2800/26 , G01N2800/7095
摘要： The present invention provides for methods and kits for detecting sepsis, trauma/hemorrhage or inflammation in a subject. It is based, at least in part, on the discovery that Augmenter of Liver Regeneration (“ALR”) is an early marker of these conditions. Accordingly, in other embodiments, the present invention provides for a method of treating sepsis, traumatic/hemorrhagic shock and inflammation by inhibiting ALR.
摘要翻译： 本发明提供了用于检测受试者中败血症，创伤/出血或炎症的方法和试剂盒。 至少部分基于发现肝脏再生增强剂（“ALR”）是这些病症的早期标志。 因此，在其它实施方案中，本发明提供了通过抑制ALR来治疗败血症，创伤/出血性休克和炎症的方法。
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公开(公告)号：US20110190680A1
公开(公告)日：2011-08-04
申请号：US13121013
申请日：2009-09-29
申请人： Yoram Vodovotz , Gregory Constantine , Jorg Christian Gerlach , Qi Mi , Maxim Mikheev , David Okonkwo , Alexey Solovyev
发明人： Yoram Vodovotz , Gregory Constantine , Jorg Christian Gerlach , Qi Mi , Maxim Mikheev , David Okonkwo , Alexey Solovyev
CPC分类号： A61M1/3489 , A61M1/0088 , A61M1/3472 , A61M1/3482 , A61M1/367 , B01D63/026
摘要： A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.
摘要翻译： 提供了一种生物反应器，其包含能够响应于细胞因子产生细胞因子抑制剂的细胞，其方式由单个患者的局部或全身环境调节并通过机械计算模拟预测。 生物反应器将细胞因子抑制剂转移到需要控制炎症过程的患者中，作为患者的疾病或病症的一部分，例如败血症，创伤，创伤性脑损伤或伤口愈合。 还提供了相关方法。
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公开(公告)号：US20130197893A1
公开(公告)日：2013-08-01
申请号：US13700244
申请日：2011-06-07
申请人： Joyeeta Dutta-Moscato , Liang-I Kang , Qi Mi , Kari Nejak-Bowen , Yoram Vodovotz
发明人： Joyeeta Dutta-Moscato , Liang-I Kang , Qi Mi , Kari Nejak-Bowen , Yoram Vodovotz
IPC分类号： G06F19/00
摘要： Provided herein are in silico methods of modeling hepatic inflammation, fibrosis/cirrhosis, and cancer. The models are computer-implemented agent-based models and are useful in determining patient prognoses in hepatic conditions, including viral infections, damage, inflammation, and cancer. The modeling system also is useful in modeling the effects of active agents on normal hepatic tissue or hepatic tissue perturbed by inflammation, infection, damage, fibrosis/cirrhosis, and cancer.
摘要翻译： 本文提供了模拟肝脏炎症，纤维化/肝硬化和癌症的电子方法。 这些模型是基于计算机实施的基于药物的模型，并且可用于确定患者在肝脏病况中的预后，包括病毒感染，损伤，炎症和癌症。 建模系统还可用于模拟活性剂对炎症，感染，损伤，纤维化/肝硬化和癌症引起的正常肝组织或肝组织的影响。
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公开(公告)号：US20120134971A1
公开(公告)日：2012-05-31
申请号：US13322066
申请日：2010-05-21
申请人： Victor Maltsev , Edward G. Lakatta , Ihor Zahanich , Syevda Sirenko , Maxim Milkheev , Yoram Vodovotz
发明人： Victor Maltsev , Edward G. Lakatta , Ihor Zahanich , Syevda Sirenko , Maxim Milkheev , Yoram Vodovotz
CPC分类号： C12N5/0657 , A61K48/005 , C12N15/86 , C12N2500/14 , C12N2501/01 , C12N2506/02 , C12N2510/00 , C12N2740/15043 , C12N2830/002
摘要： Biological pacemakers engineered to intrinsically generate rhythmic excitations are disclosed. In addition, methods of producing the biological pacemakers are disclosed. Methods of treating or preventing arrhythmia and heart disease associated with a defective pacemakers are also disclosed.
摘要翻译： 公开了设计用于固有地产生节奏兴奋的生物起搏器。 此外，公开了生产起搏器的方法。 还公开了治疗或预防与起搏器不良相关的心律失常和心脏病的方法。
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公开(公告)号：US09506032B2
公开(公告)日：2016-11-29
申请号：US13322066
申请日：2010-05-21
申请人： Victor Maltsev , Edward G. Lakatta , Ihor Zahanich , Syevda Sirenko , Maxim Mikheev , Yoram Vodovotz
发明人： Victor Maltsev , Edward G. Lakatta , Ihor Zahanich , Syevda Sirenko , Maxim Mikheev , Yoram Vodovotz
摘要： Biological pacemakers engineered to intrinsically generate rhythmic excitations are disclosed. In addition, methods of producing the biological pacemakers are disclosed. Methods of treating or preventing arrhythmia and heart disease associated with a defective pacemakers are also disclosed.
摘要翻译： 公开了设计用于固有地产生节奏兴奋的生物起搏器。 此外，公开了生产起搏器的方法。 还公开了治疗或预防与起搏器不良相关的心律失常和心脏病的方法。
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