公开(公告)号：US20160129151A1

公开(公告)日：2016-05-12

申请号：US14534869

申请日：2014-11-06

Applicant: Case Western Reserve University

Inventor： Matthew J. Fullana ,  Daniel J. Brannum ,  Gary E. Wnek

IPC: A61L27/24 ,  A61L24/00 ,  A61L27/56 ,  A61L24/10

CPC classification number: A61L27/24 ,  A61L24/0036 ,  A61L24/102 ,  A61L27/56 ,  A61L2400/06

Abstract: Gels and films can be formed from protein dissolved into a benign solvent that comprises alcohol, water, and salt. In one example, the protein can be collagen. In one example, the benign solvent can include a water to alcohol ratio of between ninety-nine-to-one and one-to-ninety-nine by volume, a salt concentration between zero moles per liter and the maximum salt concentration soluble in water, and a protein amount of between near zero percent and about 25 percent by weight as compared to the mixture of water and alcohol. Once the protein is dissolved in the benign solvent, secondary processing steps can be conducted to form protein based bioadhesives, gels, and films with desirable physical properties. Additional process steps can include washings that improve the properties of the protein structures.

Abstract translation: 凝胶和膜可以由溶解成包含醇，水和盐的良性溶剂的蛋白质形成。 在一个实例中，蛋白质可以是胶原蛋白。 在一个实例中，良溶剂可以包括体积比为九十九比一至九十九的水与醇比，每升零摩尔之间的盐浓度和可溶于水的最大盐浓度 ，并且与水和醇的混合物相比，蛋白质量在接近零％至约25重量％之间。 一旦蛋白质溶解在良性溶剂中，可以进行二次加工步骤以形成具有所需物理性质的蛋白质基生物粘附剂，凝胶和膜。 另外的方法步骤可以包括改善蛋白质结构性质的洗涤液。