公开(公告)号：US10988809B2

公开(公告)日：2021-04-27

申请号：US16553592

申请日：2019-08-28

申请人： Celera Corporation

发明人： Olga Iakoubova ,  James J. Devlin ,  Carmen Tong ,  Charles Rowland

IPC分类号： C12Q1/6883 ,  G01N33/68

摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.

公开(公告)号：US10435749B2

公开(公告)日：2019-10-08

申请号：US15150636

申请日：2016-05-10

申请人： Celera Corporation

发明人： Olga Iakoubova ,  James J. Devlin ,  Carmen Tong ,  Charles Rowland

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12Q1/6883 ,  G01N33/68

摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.

公开(公告)号：US11814684B2

公开(公告)日：2023-11-14

申请号：US17215307

申请日：2021-03-29

申请人： Celera Corporation

发明人： Olga Iakoubova ,  James J. Devlin ,  Carmen Tong ,  Charles Rowland

IPC分类号： C12Q1/6883 ,  G01N33/68

CPC分类号： C12Q1/6883 ,  G01N33/6893 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/172 ,  G01N2333/914 ,  G01N2500/04 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/329 ,  Y10T436/143333

摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.