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    GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF
    5.
    发明申请
    GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF 审中-公开

    公开(公告)号：US20190292598A1

    公开(公告)日：2019-09-26

    申请号：US15935506

    申请日：2018-03-26

    申请人： Celera Corporation

    发明人： Olga IAKOUBOVA ,  James J. DEVLIN

    IPC分类号： C12Q1/6883 ,  A61K31/70

    摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual having a cardiovascular disorder to treatment of the disorder with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

    GENETIC POLYMORPHISMS ASSOCIATED WITH STROKE, METHODS OF DETECTION AND USES THEREOF
    6.
    发明申请
    GENETIC POLYMORPHISMS ASSOCIATED WITH STROKE, METHODS OF DETECTION AND USES THEREOF 审中-公开
    与STROKE相关的遗传多态性，检测方法及其用途

    公开(公告)号：US20130303558A1

    公开(公告)日：2013-11-14

    申请号：US13655905

    申请日：2012-10-19

    申请人： CELERA CORPORATION

    发明人： May LUKE ,  James J. DEVLIN

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  A61K31/22 ,  A61K31/35 ,  A61K31/40 ,  A61K31/404 ,  A61K31/435 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with vascular diseases such as stroke. In particular, the present invention relates to genetic polymorphisms that have utility for such uses as predicting disease risk or predicting an individual's response to a treatment such as statins, including groups of polymorphisms that may be used as a signature marker set for such uses, as well as nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

    摘要翻译： 本发明提供了与诸如中风等血管疾病相关的遗传多态性的组合物和方法。 特别地，本发明涉及对预测疾病风险或预测个体对治疗的反应（例如他汀类药物）的用途的遗传多态性，所述治疗包括可以用作为此类用途设定的签名标记的多形性组，如 以及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态性核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用试剂进行检测的方法。

    GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF
    10.
    发明申请
    GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDERS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF 审中-公开
    与心血管疾病相关的遗传多态性与药物反应，检测方法及其用途

    公开(公告)号：US20150111775A1

    公开(公告)日：2015-04-23

    申请号：US14479916

    申请日：2014-09-08

    申请人： Celera Corporation

    发明人： Olga IAKOUBOVA ,  James J. DEVLIN

    IPC分类号： C12Q1/68

    摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual having a cardiovascular disorder to treatment of the disorder with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

    摘要翻译： 本发明基于与心血管疾病特别是急性冠状动脉事件（例如心肌梗死和中风）相关的遗传多态性的发现，以及与具有心血管疾病的个体的反应性相关的遗传多态性与该疾病的治疗相关 他汀 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。