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公开(公告)号：US20210077832A1
公开(公告)日：2021-03-18
申请号：US16961436
申请日：2019-01-25
发明人： Tibor KELER , Michael YELLIN , Chandan GUHA , Nitin OHRI
摘要： Methods of treating cancer comprising administering to patients a dendritic cell mobilizing agent (e.g., Flt3 ligand) in combination with radiation and/or immunoregulatory agents (e.g., checkpoint inhibitors), are disclosed.
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公开(公告)号：US20220016168A1
公开(公告)日：2022-01-20
申请号：US17298071
申请日：2019-12-10
发明人： Lizhen HE , Tibor KELER , Anna WASIUK
摘要： Methods of performing adoptive immunotherapy comprising administering to patients a CD27 antibody in combination with an adoptive immunotherapy (e.g., genetically modified autogenous and allogenous T-cells) are provided.
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公开(公告)号：US20210139597A1
公开(公告)日：2021-05-13
申请号：US17099547
申请日：2020-11-16
发明人： Vladimir CORIC , Tibor KELER , Thomas DAVIS
摘要： This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.
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公开(公告)号：US20200377606A1
公开(公告)日：2020-12-03
申请号：US16094737
申请日：2017-04-18
发明人： Tibor KELER , Joel GOLDSTEIN , Laura A. VITALE , Lizhen HE , Tom O'NEILL , Andrea CROCKER , Karuna SUNDARAPANDIYAN , Lawrence J. THOMAS , Jenifer WIDGER
IPC分类号： C07K16/28 , A61K39/395 , A61K39/385
摘要： Isolated monoclonal agonistic antibodies which bind to human CD40 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
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5.发明申请MOLECULAR CONJUGATES COMPRISING HUMAN MONOCLONAL ANTIBODIES TO DENDRITIC CELLS 审中-公开将人类单克隆抗体包含在细胞中的分子结合公开(公告)号：US20160024192A1
公开(公告)日：2016-01-28
申请号：US14750057
申请日：2015-06-25
发明人： Yashwant M. DEO , Tibor KELER , John TREML , Michael ENDRES
CPC分类号： C07K16/18 , A01K2267/01 , A61K39/0011 , A61K39/08 , A61K47/646 , A61K47/6849 , A61K2039/505 , A61K2039/6056 , C07K14/33 , C07K14/473 , C07K14/705 , C07K16/28 , C07K16/2851 , C07K16/46 , C07K2317/21 , C07K2317/54 , C07K2317/56 , C07K2317/622 , C07K2317/77 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/55
摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to dendritic cells are disclosed. Also disclosed are bispecifics, immunotoxins and antigen conjugates which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与树突状细胞特异性结合的分离的人单克隆抗体及其抗原结合部分。 还公开了包括抗体或抗体部分的双特异性，免疫毒素和抗原缀合物。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的非人转基因动物，例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
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公开(公告)号：US20220227877A1
公开(公告)日：2022-07-21
申请号：US17507895
申请日：2021-10-22
发明人： Tibor KELER , Henry C. MARSH , Lizhen HE , Laura A. VITALE , Lawrence J. THOMAS
IPC分类号： C07K16/28
摘要： Isolated monoclonal antibodies which bind to human CD27 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
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公开(公告)号：US20220025063A1
公开(公告)日：2022-01-27
申请号：US17405861
申请日：2021-08-18
发明人： Tibor KELER , Joel GOLDSTEIN , Laura A. VITALE , Lizhen HE
摘要： Provided herein are novel anti-CD27 and anti-PD-L1 antibodies, and binding domains thereof, as well as bispecific constructs and anti-CD27 binding domain linked to an anti-PD-L1 binding domain. Also provided herein are methods of stimulating T cell activity, methods of inducing or enhancing an immune response, and methods of treating a disease or condition (e.g., cancer) by administering the bispecific constructs, antibodies, or antigen binding fragments thereof, or compositions described herein to a patient in need thereof.
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公开(公告)号：US20190322743A1
公开(公告)日：2019-10-24
申请号：US16376585
申请日：2019-04-05
发明人： Tibor KELER , Joel GOLDSTEIN , Laura A. VITALE , Lizhen HE , Tom O'NEILL , Andrea CROCKER , Karuna SUNDARAPANDIYAN , Lawrence J. THOMAS , Jenifer WIDGER
IPC分类号： C07K16/28 , C07K14/715 , C07K14/54 , A61K39/395
摘要： Isolated monoclonal agonistic antibodies which bind to human CD40 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
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公开(公告)号：US20240360235A1
公开(公告)日：2024-10-31
申请号：US18628224
申请日：2024-04-05
发明人： Vladimir CORIC , Tibor KELER , Thomas DAVIS
CPC分类号： C07K16/2878 , A61K39/00 , A61K39/0008 , A61K39/0011 , A61K39/001129 , A61K39/00115 , A61K39/39558 , A61K45/06 , A61P35/00 , C07K16/2818 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K16/3069 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K2317/21 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.
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公开(公告)号：US20200369768A1
公开(公告)日：2020-11-26
申请号：US16986613
申请日：2020-08-06
发明人： Tibor KELER , Joel GOLDSTEIN , Laura A. VITALE , Lizhen HE , Tom O'NEILL , Andrea CROCKER , Karuna SUNDARAPANDIYAN , Lawrence J. THOMAS , Jenifer WIDGER
IPC分类号： C07K16/28 , A61K39/395 , C07K14/54 , C07K14/715
摘要： Isolated monoclonal agonistic antibodies which bind to human CD40 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
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