公开(公告)号：US20160296642A1

公开(公告)日：2016-10-13

申请号：US14783684

申请日：2014-08-26

申请人： CELSENSE, INC.

发明人： Brooke M. Helfer ,  Anthony G. Balducci ,  Charles F. O'Hanlon, III

IPC分类号： A61K49/12 ,  A61K49/18

CPC分类号： A61K49/126 ,  A61B5/055 ,  A61K49/12 ,  A61K49/1896 ,  A61K51/0423 ,  A61K51/1203

摘要： Compositions and methods for assessing inflammation in a subject. The present disclosure provides compositions for labeling leukocytes with a 19F-containing perfluoropolyether molecule ex vivo. In some examples, the leukocytes are obtained from the patient, enriched in a whole blood fraction, and then labeled. The labeled cells may be re-introduced into the patient. The leukocytes may accumulate at a site of inflammation, thus permitting non-invasive evaluation of inflammation in patients. The present methods provide a tool for assessing inflammation in a wide variety of autoimmune diseases and may have particular utility in intestinal diseases such as Crohn's disease, ulcerative colitis, inflammatory bowel disease, and cardio myositis.

摘要翻译： 用于评估受试者炎症的组合物和方法。 本公开内容提供了离子用含19F的全氟聚醚分子标记白细胞的组合物。 在一些实例中，从患者获得白细胞，富集全血分数，然后标记。 可以将标记的细胞重新导入患者体内。 白细胞可能积聚在炎症部位，从而允许对患者的炎症进行非侵入性评估。 本发明的方法提供了用于评估多种自身免疫疾病中的炎症的工具，并且可以在诸如克罗恩病，溃疡性结肠炎，炎性肠病和心脏肌炎的肠道疾病中具有特别的用途。

公开(公告)号：US20160235872A1

公开(公告)日：2016-08-18

申请号：US15043004

申请日：2016-02-12

申请人： Celsense, Inc.

发明人： Brooke M. Helfer ,  Anthony G. Balducci ,  Charles F. O'Hanlon, III

IPC分类号： A61K51/12 ,  A61B5/055 ,  A61K51/04

CPC分类号： A61K49/126 ,  A61B5/055 ,  A61K49/12 ,  A61K49/1896 ,  A61K51/0423 ,  A61K51/1203

摘要： Compositions and methods for assessing inflammation in a subject. The preset disclosure provides compositions for labeling leukocytes with a 19F-containing perfluoropolyether molecule ex vivo. In some examples, the leukocytes are obtained from the patient, enriched in a whole blood fraction, and then labeled. The labeled cells may be re-introduced into the patient. The leukocytes may accumulate at a site of inflammation, thus permitting non-invasive evaluation of inflammation in patients. The present methods provide a tool for assessing inflammation in a wide variety of autoimmune diseases and may have particular utility in intestinal diseases such as Crohn's disease, ulcerative colitis, inflammatory bowel disease, and cardio myositis.

摘要翻译： 用于评估受试者炎症的组合物和方法。 该预设的公开内容提供了用离子标记含有19F的全氟聚醚分子标记白细胞的组合物。 在一些实例中，从患者获得白细胞，富集全血分数，然后标记。 可以将标记的细胞重新导入患者体内。 白细胞可能积聚在炎症部位，从而允许对患者的炎症进行非侵入性评估。 本发明的方法提供了用于评估多种自身免疫疾病中的炎症的工具，并且可以在诸如克罗恩病，溃疡性结肠炎，炎性肠病和心脏肌炎的肠道疾病中具有特别的用途。