公开(公告)号：US10336718B2

公开(公告)日：2019-07-02

申请号：US15739498

申请日：2016-06-24

Applicant: Central Glass Company, Limited

Inventor： Tetsuro Nishii ,  Ayumi Yamaguchi ,  Takashi Ootsuka ,  Naoki Sawai

IPC: C07D307/89 ,  C07D301/26 ,  C07C29/143 ,  C07C31/34 ,  C07B53/00 ,  C07D303/08 ,  C12P7/04 ,  C07C31/42 ,  C07C29/10 ,  C12R1/72 ,  C12R1/645

Abstract: It is possible to produce an optically active fluoroalkyl chloromethyl alcohol with a high optical purity and a good yield by treating a fluoroalkyl chloromethyl ketone with a microorganism having an activity for asymmetrically reducing the ketone or an enzyme having the activity. Then, it is possible to obtain a fluoroalkyl ethylene oxide by treating the alcohol with a base. Industrial implementation of the production method of the present invention is easy.