公开(公告)号：US20190292546A1

公开(公告)日：2019-09-26

申请号：US16348775

申请日：2017-11-10

申请人： Centre Léon-Bérard ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  Centre national de la recherche scientifique ,  Université Claude Bernard Lyon 1 ,  HOSPICES CIVILS DE LYON

发明人： Serge LEBECQUE ,  Toufic RENNO ,  Béatrice VANBERVLIET ,  Yann ESTORNES

IPC分类号： C12N15/117 ,  C12N5/09 ,  A61K31/337 ,  A61N5/10

摘要： The present invention relates to a TLR3 agonist for use for inducing apoptosis in senescent cancer cells, in particular to a TLR3 agonist for use as a medicament for inducing apoptosis in senescent cancer cells. In particular, it relates to a TLR3 agonist for use for the treatment of cancer, optionally in combination with a chemotherapeutic agent or with radiotherapy. It further relates to a pharmaceutical composition comprising a TLR3 agonist and a chemotherapeutic agent.

公开(公告)号：US20210292328A1

公开(公告)日：2021-09-23

申请号：US16334513

申请日：2017-09-20

申请人： CENTRE LEON BERARD ,  HOSPICES CIVILS DE LYON ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Toufic RENNO ,  Isabelle COSTE-INVERNIZZI ,  Stéphane GIRAUD ,  Serge LEBECQUE

IPC分类号： C07D487/04 ,  C07D235/18 ,  C07D401/12 ,  C07D403/12 ,  C07D401/04 ,  C07D413/12 ,  C07D405/12 ,  C07D403/04 ,  C07D401/14 ,  A61K45/06 ,  C07D417/12

摘要： The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.

公开(公告)号：US20220348587A1

公开(公告)日：2022-11-03

申请号：US17831592

申请日：2022-06-03

申请人： CENTRE LEON BERARD ,  HOSPICES CIVILS DE LYON ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHESCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Toufic RENNO ,  Isabelle COSTE-INVERNIZZI ,  Stéphane GIRAUD ,  Serge LEBECQUE

IPC分类号： C07D487/04 ,  A61K45/06 ,  C07D235/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing the compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.