公开(公告)号：US20240363787A1

公开(公告)日：2024-10-31

申请号：US18648930

申请日：2024-04-29

申请人： ALMAE TECHNOLOGIES ,  Centre national de la recherche scientifique ,  Université Paris-Saclay

发明人： Deeb Claire ,  Pelouard Jean-Luc ,  Pardo Fabrice

IPC分类号： H01L31/108 ,  H01L31/0224 ,  H01L31/028 ,  H01L31/18

CPC分类号： H01L31/1085 ,  H01L31/022408 ,  H01L31/028 ,  H01L31/1804

摘要： The present disclosure relates to a metal-semiconductor-metal photodetector configured to detect incident light in a given range of wavelengths comprising: an absorbing semiconductor layer (325); a first semiconductor layer (321) made of a first semiconductor material and in electrical contact with said absorbing semiconductor layer; a first metal electrode (340) in electrical contact with the first semiconductor layer (321), configured to produce with the first semiconductor layer (321), an electron Schottky junction, wherein the first semiconductor layer is arranged between said first metal electrode and the absorbing semiconductor layer; a second semiconductor layer (322) made of a second semiconductor material different from the first semiconductor material, in electrical contact with said absorbing semiconductor layer; a second metal electrode (330) in electrical contact with the second semiconductor layer configured to produce with the second semiconductor layer, a hole Schottky junction, wherein the second semiconductor layer is arranged between said second metal electrode and the absorbing semiconductor layer.

公开(公告)号：US20240361321A1

公开(公告)日：2024-10-31

申请号：US18685111

申请日：2022-08-23

申请人： INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Thierry ROSE ,  Sophie GOYARD ,  Yves JANIN ,  Pierre LAFAYE ,  Gabriel AYME ,  Nicolas ESCRIOU ,  Marion GRANSAGNE

IPC分类号： G01N33/569 ,  C07K16/10 ,  C12Q1/66 ,  G01N33/68

CPC分类号： G01N33/56988 ,  C07K16/1003 ,  C07K16/1054 ,  C12Q1/66 ,  G01N33/6854 ,  C07K2317/22 ,  C07K2317/569 ,  C07K2319/61 ,  G01N2333/161 ,  G01N2333/165 ,  G01N2333/90241

摘要： System for detecting an antigen comprising: —a first fusion protein with no luciferase activity comprising: —a N-terminal domain which comprises a first single domain antibody which is directed against a first epitope of said antigen and —a C-terminal domain which comprises a first fragment of a luciferase having the amino acid sequence SEQ ID NO: 1 or is a variant thereof and —a second fusion protein with no luciferase activity comprising: —a N-terminal domain which comprises a second single domain antibody which is directed against a second epitope of said antigen and —a C-terminal domain which comprises a second fragment of a luciferase having the amino acid sequence SEQ ID NO: 2 or is a variant thereof. Luminescence is emitted in the presence of a substrate when both the first fusion protein and the second fusion protein bind to said antigen.

公开(公告)号：US20240360401A1

公开(公告)日：2024-10-31

申请号：US18287728

申请日：2022-04-21

申请人： ETABLISSEMENT FRANÇAIS DU SANG ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE DE STRASBOURG ,  AVIGNON UNIVERSITE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'AIX MARSEILLE ,  ECOLE CENTRALE DE MARSEILLE

发明人： Catherine STRASSEL ,  Léa MALLO ,  Valentin DO SACRAMENTO ,  Eric BERTRAND ,  Yannick KNAPP

IPC分类号： C12M1/00 ,  C12M3/04

CPC分类号： C12M47/04 ,  C12M23/34 ,  C12M27/10

摘要： The disclosure relates to a method for releasing platelets from megakaryocytes contained in a fluid (F), the method being carried out by means of a system comprising two concentric cylinders, an inner cylinder comprising a cylindrical wall and a hollow outer cylinder located radially external to the inner cylinder, the outer cylinder comprising a cylindrical wall of a base at which the second cylinder is closed, the cylinders being separated by a space devoid of any mechanical parts, the space being intended to receive the fluid (F), the method comprising the following steps: supplying the space with a fluid (F) comprising megakaryocytes, rotating the inner cylinder about its axis, the outer cylinder being stationary, or moving the two cylinders in opposite directions about their axes, so as to generate an at least partially turbulent flow of fluid (F) in the space and obtain a second fluid (F′) enriched in platelets.

公开(公告)号：US20240353666A1

公开(公告)日：2024-10-24

申请号：US18685292

申请日：2022-08-24

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'AIX MARSEILLE ,  ECOLE CENTRALE DE MARSEILLE ,  UNIVERSITE DE MONTPELLIER

发明人： Anita MOUTTOU ,  Julien LUMEAU ,  Aude LEREU ,  Cyril FAVARD

IPC分类号： G02B21/16 ,  G02B5/26 ,  G02B21/08 ,  G02B21/34 ,  G02B27/56

CPC分类号： G02B21/16 ,  G02B5/265 ,  G02B21/082 ,  G02B21/34 ,  G02B27/56

摘要： An optical slide intended to receive a biological sample for the purposes of total internal reflection microscopy. Such an optical slide includes a glass base substrate and a stack of thin layers of alternating dielectric materials which is arranged on the substrate, the free layer of the stack being biocompatible. The stack has index and layer thickness characteristics for supporting the surface waves at the interface between the free layer and the sample, such that the imaging sensitivity and resolution of total internal reflection microscopy are improved.

公开(公告)号：US12123076B2

公开(公告)日：2024-10-22

申请号：US17421554

申请日：2020-01-14

申请人： SAFRAN ,  UNIVERSITE DE NANTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Jérémy Rame ,  Edern Menou ,  Clara Desgranges ,  Franck Tancret

IPC分类号： C22C19/05 ,  F01D5/28

CPC分类号： C22C19/057 ,  F01D5/28 ,  F05D2300/175 ,  F05D2300/607

摘要： A nickel-based superalloy includes, in weight percent, 6 to 8% aluminum, 12 to 15% cobalt, 4 to 8% chromium, 0 to 0.2% hafnium, 0.5 to 4% molybdenum, 3.5 to 6% rhenium, 4 to 6% tantalum, 1 to 3% titanium, 0 to 2% tungsten, 0 to 0.1% silicon, the balance being nickel and unavoidable impurities.

公开(公告)号：US20240346263A1

公开(公告)日：2024-10-17

申请号：US18701072

申请日：2022-10-11

申请人： INSTITUT POLYTECHNIQUE DE GRENOBLE ,  UNIVERSITE GRENOBLE ALPES ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON ,  ECOLE CENTRALE DE LYON ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Smail TEDJINI ,  Dahmane ALLANE ,  Yvan DUROC

IPC分类号： G06K7/10

CPC分类号： G06K7/10316 ,  G06K7/10366

摘要： A novel RFID communication device is proposed which allows the detection and electronic processing not only of the response signal backscattered at the fundamental frequency f0 of the reader, but also at least one response signal backscattered at a harmonic frequency, before feeding them to the conventional receive chain of an RFID reader. The joint use of the signal at the fundamental frequency of the reader and at least one signal at a harmonic frequency allows the reader's performance to be improved. The RFID reader can additionally be provided with novel functionalities by virtue of suitable software processing. It is applicable to the field of communications between a reader and passive transponders in UHF RFID and to the field of the Internet of Things.

公开(公告)号：US20240336580A1

公开(公告)日：2024-10-10

申请号：US18580545

申请日：2022-07-19

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITÉ DE STRASBOURG

发明人： Laurent DOUCE ,  Nicolas DEL GIUDICE ,  Alexander KANE ,  Louise STUTTGE

IPC分类号： C07D263/32 ,  G01T1/203 ,  G01T1/204 ,  G01T3/06

CPC分类号： C07D263/32 ,  G01T1/2033 ,  G01T1/2042 ,  G01T3/06

摘要： The invention relates to a compound having one of the following ionic chemical structures (I), “R” represents an “alkyl” or “O-alkyl” group optionally comprising one or more unsaturations, as a linear or branched chain, of 1 to 30 carbon atoms, optionally substituted; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 represent, independently of one another, an atom or a group of atoms; “(Het)aryl” independently represents an aryl or heteroaryl group; and “A” represents an anion.

公开(公告)号：US12112853B2

公开(公告)日：2024-10-08

申请号：US17611997

申请日：2020-05-29

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  UNIVERSITE PARIS-SACLAY ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—

发明人： Irène Buvat

IPC分类号： G06N3/08 ,  G06T7/00 ,  G16H20/10 ,  G16H50/30

CPC分类号： G16H50/30 ,  G06T7/0014 ,  G16H20/10 ,  G06T2207/10104 ,  G06T2207/30096

摘要： The present invention relates to a method for assisting with lymphoma prognosis. The prognosis of therapeutic response of patients with lymphoma is difficult. Based on a study of advanced stage DLBCL patients, the inventors showed that medical imaging such as 18F-FDG-PET/CT can provide a prognostic radiomic signature combining metrics reflecting tumor dissemination and tumor burden. In another aspect, the invention relates to a computer software comprising instructions to implement at least a part of a method according to the invention. In yet another aspect, the invention relates to a computer-readable non-transient recording medium on which a software is registered to implement a method according to the invention.

公开(公告)号：US12110551B2

公开(公告)日：2024-10-08

申请号：US17563107

申请日：2021-12-28

申请人： BIO-RAD EUROPE GMBH ,  ARIANA PHARMACEUTICALS ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Bénédicte Watelet ,  Tarik Asselah ,  Ivan Bieche ,  Isabelle Catherine Batxelli ,  Nathalie Jullian ,  Michel Vidaud ,  Patrick Marcellin ,  Daniel Laune ,  Mohammad Afshar ,  Eve Mathieu Dupas

IPC分类号： C12Q1/68 ,  C12Q1/6876 ,  C12Q1/6883 ,  G01N33/576 ,  C12Q1/70

CPC分类号： C12Q1/6876 ,  C12Q1/6883 ,  G01N33/576 ,  C12Q1/706 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2800/085 ,  G01N2800/60 ,  G01N2800/7052

摘要： The application concerns means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score of subjects infected with one or more hepatitis viruses. In particular, the means of the invention involve measuring the levels of expression of selected genes, said selected genes being:



SPP1, and
at least one gene from among A2M and VIM, and
at least one gene from among IL8, CXCL10 and ENG, and
optionally, at least one gene from among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.

公开(公告)号：US20240328025A1

公开(公告)日：2024-10-03

申请号：US18703202

申请日：2022-10-21

申请人： SAFRAN AIRCRAFT ENGINES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE ,  UNIVERSITE PAUL SABATIER-TOULOUSE III

发明人： Julien Pierre WAGNER ,  Léa Rébecca GANI ,  Stéphane KNITTEL ,  Florence ANSART ,  Pierre-Louis TABERNA

IPC分类号： C25D13/02 ,  C25D13/14 ,  C25D13/22

CPC分类号： C25D13/02 ,  C25D13/14 ,  C25D13/22

摘要： A method for forming a cathodic protection coating on a substrate forming a turbomachine part, includes deposition, on the substrate, of particles for cathodic protection of the substrate, this deposition being performed by electrophoresis from an organic electrolyte including the particles, and forming an inorganic matrix in pores of the deposit of particles produced in this way, including impregnating the deposit with an impregnation composition, drying heat treatment of the deposit impregnated by the impregnation composition, and densifying the deposit by mechanical compacting, after the drying heat treatment, in order to make the deposit electrically conductive.