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1.发明申请公开(公告)号：US20200377892A1
公开(公告)日：2020-12-03
申请号：US16643293
申请日：2018-08-31
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , HOSPICES CIVILS DE LYON , Centre Léon-Bérard , Centre national de la recherche scientifique , Université Claude Bernard Lyon 1
IPC分类号： C12N15/113
摘要： The present invention concerns an inhibitor for use for preventing and/or treating an infection with hepatitis B virus (HBV) and an in vitro screening method for the identification of a candidate compound suitable for preventing and/or treating an infection with hepatitis B virus. Inventors show that the knock-down of histone chaperone HIRA before HBV inoculation led to a strong decrease in HBV cccDNA (covalently closed circular DNA) accumulation and stable rcDNA (relaxed circular DNA) levels, in HepG2-NTCP cell line, indicating either a possible incomplete or delayed rcDNA to cccDNA transition. This effect was independent from HBx protein expression in Primary human hepatocytes (PHH). HIRA is able to interact with cccDNA and its recruitment is concomitant with deposition of histone variant H3.3 in HepG2-NTCP cell line. HIRA was able to interact with HBc (HBV capsid protein) in infected hepatocytes and in an HepaRG cell line expressing HBc in an inducible manner.
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2.发明公开公开(公告)号：US20230306598A1
公开(公告)日：2023-09-28
申请号：US18091988
申请日：2022-12-30
申请人： Owkin Inc. , Owkin France SAS , Centre Léon Bérard
发明人： Gilles WAINRIB , Thomas CLOZEL , Pierre COURTIOL , Charles MAUSSION , Jean-Yves BLAY , Françoise GALATEAU SALLE
CPC分类号： G06T7/0014 , G06N3/08 , G06T7/11 , G06T7/194 , G16H30/20 , G06T2207/10056 , G06T2207/20021 , G06T2207/20081 , G06T2207/20084 , G06T2207/30024
摘要： A method and apparatus of a device that classifies a mesothelioma image is described. In an exemplary embodiment, the device segments the mesothelioma image into a region of interest that includes information useful for classification, and a background region, by applying a first convolutional neural network. In addition, the device tiles the region of interest into a set of tiles. For each tile, the device extracts a feature vector of that tile by applying a second convolutional neural network, where the features of the feature vectors represent local descriptors of the tile. Furthermore, the device processes the extracted feature vectors of the set of tiles to classify the image.
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公开(公告)号：US11589838B2
公开(公告)日：2023-02-28
申请号：US16980875
申请日：2019-03-15
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE LÉON-BÉRARD , UNIVERSITÉ CLAUDE BERNARD LYON 1
摘要： This method, for determining the local intensity (I0) of an acoustic field propagating in a target region of a soft solid, at a position located within said target region, includes at least the following steps: determining (102) a value of an ultrasound attenuation coefficient (α) of the soft body in the target region; determining (104) a value of the shear modulus (μ) of the soft body in the target region; determining (106) a value of the speed of sound (c) in the target region of the soft body; and building (110), with the values determined in steps a), b) and c), a viscoelastic model (M) of a steady-state displacement induced by an acoustic field having a time invariant shape or a viscoelastic model of a difference between two steady-state displacements induced by an acoustic field having a time invariant shape. Moreover, this method also includes the following steps: applying (112) to the target region the acoustic field emitted by an ultrasound source, for a duration such that the acoustic field induces a steady-state localized deformation (Formula (I)) of the soft body in the target region; measuring (114) at least one steady state displacement induced by the acoustic field at a given position in the target region; and computing (116) the amplitude of the intensity of the acoustic field at said given position by inverting the viscoelastic model (M) at said given position, for the displacement(s) measured at step f).
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公开(公告)号：US11544851B2
公开(公告)日：2023-01-03
申请号：US17185924
申请日：2021-02-25
申请人： Owkin Inc. , Owkin France SAS , Centre Léon Bérard
发明人： Gilles Wainrib , Thomas Clozel , Pierre Courtiol , Charles Maussion , Jean-Yves Blay , Françoise Galateau Sallé
摘要： A method and apparatus of a device that classifies a mesothelioma image is described. In an exemplary embodiment, the device segments the mesothelioma image into a region of interest that includes information useful for classification, and a background region, by applying a first convolutional neural network. In addition, the device tiles the region of interest into a set of tiles. For each tile, the device extracts a feature vector of that tile by applying a second convolutional neural network, where the features of the feature vectors represent local descriptors of the tile. Furthermore, the device processes the extracted feature vectors of the set of tiles to classify the image.
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公开(公告)号：US11540806B2
公开(公告)日：2023-01-03
申请号：US15763717
申请日：2016-09-29
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITÉ CLAUDE BERNARD LYON 1 , CENTRE LÉON-BÉRARD
摘要： This device (2) for generating ultrasonic waves in a target region of a soft solid, includes at least two ultrasound sources (32), light sources (40) distributed around a central axis (X2) of the device (2), for enlightening a zone of the soft solid via subsurface scattering, and a video camera (50), for capturing images of the zone enlightened by the lighting means. The ultrasound source (32), the light sources (40) and the video camera (50) are mounted on a body of the device (20) and oriented toward a common target zone which includes a focal point of the ultrasound sources (32). A boresight of the video camera is aligned on the central axis (X2).
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公开(公告)号：US20210256699A1
公开(公告)日：2021-08-19
申请号：US17185924
申请日：2021-02-25
申请人： Owkin Inc. , Owkin France SAS , Centre Léon Bérard
发明人： Gilles Wainrib , Thomas Clozel , Pierre Courtiol , Charles Maussion , Jean-Yves Blay , Françoise Galateau Sallé
摘要： A method and apparatus of a device that classifies a mesothelioma image is described. In an exemplary embodiment, the device segments the mesothelioma image into a region of interest that includes information useful for classification, and a background region, by applying a first convolutional neural network. In addition, the device tiles the region of interest into a set of tiles. For each tile, the device extracts a feature vector of that tile by applying a second convolutional neural network, where the features of the feature vectors represent local descriptors of the tile. Furthermore, the device processes the extracted feature vectors of the set of tiles to classify the image.
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公开(公告)号：US20190292546A1
公开(公告)日：2019-09-26
申请号：US16348775
申请日：2017-11-10
申请人： Centre Léon-Bérard , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre national de la recherche scientifique , Université Claude Bernard Lyon 1 , HOSPICES CIVILS DE LYON
IPC分类号： C12N15/117 , C12N5/09 , A61K31/337 , A61N5/10
摘要： The present invention relates to a TLR3 agonist for use for inducing apoptosis in senescent cancer cells, in particular to a TLR3 agonist for use as a medicament for inducing apoptosis in senescent cancer cells. In particular, it relates to a TLR3 agonist for use for the treatment of cancer, optionally in combination with a chemotherapeutic agent or with radiotherapy. It further relates to a pharmaceutical composition comprising a TLR3 agonist and a chemotherapeutic agent.
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公开(公告)号：US20200232974A1
公开(公告)日：2020-07-23
申请号：US16090006
申请日：2017-03-30
申请人： Centre Léon-Bérard
发明人： Christine MENETRIER-CAUX , Nicolas GOURDIN , Christophe CAUX , Selena VIGANO , Pedro ROMERO , Marion BOSSENEC
IPC分类号： G01N33/50 , G01N33/574
摘要： The invention discloses a method for selecting a human patient for CD73 antagonist therapy, preferably immunotherapy, comprising the step of determination in a patient's biological sample, that lymphocytes, preferably CD4+ T cells, express CD73, wherein, upon a determination that lymphocytes, preferably CD4+ T cells, express CD73 in patient's biological sample, the patient is declared sensitive to immunotherapy using an antagonist of CD73, preferably an anti-CD73 antibody. Combined therapy with immunotherapy against an inhibitory ICP and/or with a chemotherapeutic agent sensitive to MDR1 exclusion activity is proposed.
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公开(公告)号：US20180348168A1
公开(公告)日：2018-12-06
申请号：US15778703
申请日：2016-11-25
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITÉ CLAUDE BERNARD LYON 1 , CENTRE LÉON-BÉRARD
CPC分类号： G01N29/041 , A61B8/085 , A61B8/0858 , A61B8/4444 , A61B8/485 , A61B8/5223 , A61N7/02 , A61N2007/0052 , A61N2007/0095 , G01N2291/0231 , G01N2291/0427 , G01S7/52022 , G01S7/52042 , G01S15/8922 , G01S15/8927
摘要： This method for determining a mechanical property of a layered soft material, includes steps of a) generating an ultrasound wave (W1) focused towards a first point (P1) of the material, said wave, upon interacting with a layer of said material, generating in turn a Lamb (L1) wave propagating into said layer of the material, b) measuring, at a second point (P2) of the material belonging to said layer, a physical parameter of the generated Lamb wave, c) automatically determining the mechanical property of the layered soft material, based on the measured physical parameter. Step a) is performed by exciting a first ultrasonic transducer (401) with a first excitation signal (S401) during at most 50 ms, step b) is performed by exciting a second ultrasonic transducer (402) with a second excitation signal (S402) during at most 0.5 ms, to generate multiple excitation ultrasound waves (W2) focused towards said second point (P2) and, then, collecting multiple reflected waves (W2′) emitted in response, said first and second ultrasonic transducers each comprises an oscillator having a quality factor equal to or superior to 100, preferably equal or superior to 1000.
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10.发明申请公开(公告)号：US20180317884A1
公开(公告)日：2018-11-08
申请号：US15763717
申请日：2016-09-29
申请人： INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITÉ CLAUDE BERNARD LYON 1 , CENTRE LÉON-BÉRARD
CPC分类号： A61B8/4483 , A61B90/36 , A61B90/37 , A61B2017/22008 , A61B2090/378 , A61N7/02 , A61N2007/0078
摘要： This device (2) for generating ultrasonic waves in a target region of a soft solid, includes at least two ultrasound sources (32), light sources (40) distributed around a central axis (X2) of the device (2), for enlightening a zone of the soft solid via subsurface scattering, and a video camera (50), for capturing images of the zone enlightened by the lighting means. The ultrasound source (32), the light sources (40) and the video camera (50) are mounted on a body of the device (20) and oriented toward a common target zone which includes a focal point of the ultrasound sources (32). A boresight of the video camera is aligned on the central axis (X2).
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