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公开(公告)号：US09463235B2
公开(公告)日：2016-10-11
申请号：US14655227
申请日：2013-12-16
发明人： Lisset Hermida Cruz , Lázaro Gil González , Alienys Izquierdo Oliva , Ernesto Marcos López , Edith Suzarte Portal , Gerardo Enrique Guillén Nieto , María Guadalupe Guzmán Tirado , Iris Valdés Prado , Laura Lazo Vazquez , Angelica de la Caridad Garcia Arechavaleta , Mayling Alvarez Vera , Jorge Castro Velazco , Lázaro López Fernández , Rosa Liset Ramírez Bartutis , Yusleidi de la Caridad Pérez Fuentes , Olga Lidia Pérez Guevara , Yaremy Romero Fernández
IPC分类号： A61K39/12 , C07K14/005 , C07K16/10 , A61K39/00 , C12N7/00
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/55505 , A61K2039/55561 , A61K2039/70 , C07K14/005 , C07K16/10 , C12N7/00 , C12N2770/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24151 , C12N2770/24161 , Y02A50/386
摘要： Vaccine compositions that comprise at least one antigen based on the dengue virus (DV) capsid protein and the oligonucleotide identified as SEQ ID NO 1. The vaccine composition that comprises a fusion protein formed by the DV2 capsid and domain III of the envelope protein of the same serotype, together with the oligonucleotide identified as SEQ ID NO 1, gives rise to higher levels of cellular immune response and protection in mice as compared with that produced by formulations of the same antigen together with oligonucleotides with potential adjuvant capacity which were reported previously. The efficacy of the compositions that comprise the SEQ ID NO 1 oligonucleotide has been demonstrated in non-human primates. These compositions may be monovalent, bivalent or tetravalent and are combined in different immunization regimes with a view to inducing a functional immune response to the four viral serotypes.
摘要翻译： 包含至少一种基于登革病毒（DV）衣壳蛋白的抗原和鉴定为SEQ ID NO 1的寡核苷酸的疫苗组合物。该疫苗组合物包含由DV2衣壳和III型包膜蛋白形成的融合蛋白 与以前报道的具有潜在的佐剂能力的寡核苷酸相比，同样的血清型连同被鉴定为SEQ ID NO 1的寡核苷酸一起导致小鼠细胞免疫应答和保护水平的提高。 包含SEQ ID NO 1寡核苷酸的组合物的功效已在非人灵长类动物中证实。 这些组合物可以是一价的，二价的或四价的，并且在不同的免疫方案中组合，以诱导对四种病毒血清型的功能性免疫应答。
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公开(公告)号：US20150328304A1
公开(公告)日：2015-11-19
申请号：US14655227
申请日：2013-12-16
发明人： Lisset Hermida Cruz , Lázaro Gil González , Alienys Izquierdo Oliva , Ernesto Marcos López , Edith Suzarte Portal , Gerardo Enrique Guillén Nieto , María Guadalupe Guzmán Tirado , Iris Valdés Prado , Laura Lazo Vazquez , Angelica de la Caridad García Arechavaleta , Mayling Alvarez Vera , Jorge Castro Velazco , Lázaro López Fernández , Rosa Liset Ramírez Bartutis , Yusleidi de la Caridad Pérez Fuentes , Olga Lidia Pérez Guevara , Yaremy Romero Fernández
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/55505 , A61K2039/55561 , A61K2039/70 , C07K14/005 , C07K16/10 , C12N7/00 , C12N2770/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24151 , C12N2770/24161 , Y02A50/386
摘要： Vaccine compositions that comprise at least one antigen based on the dengue virus (DV) capsid protein and the oligonucleotide identified as SEQ ID NO 1. The vaccine composition that comprises a fusion protein formed by the DV2 capsid and domain III of the envelope protein of the same serotype, together with the oligonucleotide identified as SEQ ID NO 1, gives rise to higher levels of cellular immune response and protection in mice as compared with that produced by formulations of the same antigen together with oligonucleotides with potential adjuvant capacity which were reported previously. The efficacy of the compositions that comprise the SEQ ID NO 1 oligonucleotide has been demonstrated in non-human primates. These compositions may be monovalent, bivalent or tetravalent and are combined in different immunization regimes with a view to inducing a functional immune response to the four viral serotypes.
摘要翻译： 包含至少一种基于登革病毒（DV）衣壳蛋白的抗原和鉴定为SEQ ID NO 1的寡核苷酸的疫苗组合物。该疫苗组合物包含由DV2衣壳和III型包膜蛋白形成的融合蛋白 与以前报道的具有潜在的佐剂能力的寡核苷酸相比，同样的血清型连同被鉴定为SEQ ID NO 1的寡核苷酸一起导致小鼠细胞免疫应答和保护水平的提高。 包含SEQ ID NO 1寡核苷酸的组合物的功效已在非人灵长类动物中证实。 这些组合物可以是一价的，二价的或四价的，并且在不同的免疫方案中组合，以诱导对四种病毒血清型的功能性免疫应答。
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