公开(公告)号：US20140323435A1

公开(公告)日：2014-10-30

申请号：US14285007

申请日：2014-05-22

Applicant: Cancer Research Technology Limited ,  Cephalon, Inc.

Inventor： Bruce D. Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R. Ott ,  Jonathan R.A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC: C07D495/04 ,  C07D495/20 ,  C07F7/08 ,  C07D495/14

CPC classification number: C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07D519/00 ,  C07F7/0812

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

Abstract translation: 本申请提供式（I）化合物或其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，A，G，M，Q和X如本文所定义。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。

公开(公告)号：US09238656B2

公开(公告)日：2016-01-19

申请号：US14446411

申请日：2014-07-30

Applicant: Cephalon, Inc.

Inventor： Henry J. Breslin ,  Matthew A. Curry ,  Diane E. Gingrich ,  Keith S. Learn ,  Gregory R. Ott ,  Jason C. Wagner

IPC: C07D493/08 ,  C07D491/107 ,  C07D471/04 ,  A61K31/47 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61P35/00

CPC classification number: C07D493/08 ,  C07D471/04 ,  C07D491/107

Abstract: This application relates to compounds of the Formula I as defined herein, and/or salts thereof. This application further relates to compositions and methods of using these compounds and/or salts thereof. The compounds of Formula I are useful as ALK and JAK modulators for the treatment of proliferative disorders.

Abstract translation: 本申请涉及本文定义的式I化合物和/或其盐。 本申请还涉及使用这些化合物和/或其盐的组合物和方法。 式I的化合物可用作治疗增殖性疾病的ALK和JAK调节剂。

公开(公告)号：US20140350011A1

公开(公告)日：2014-11-27

申请号：US14446411

申请日：2014-07-30

Applicant: Cephalon, Inc.

Inventor： Henry J. Breslin ,  Matthew A. Curry ,  Diane E. Gingrich ,  Keith S. Learn ,  Gregory R. Ott ,  Jason C. Wagner

IPC: C07D493/08 ,  C07D491/107 ,  C07D471/04

CPC classification number: C07D493/08 ,  C07D471/04 ,  C07D491/107

Abstract: This application relates to compounds of the Formula I as defined herein, and/or salts thereof. This application further relates to compositions and methods of using these compounds and/or salts thereof. The compounds of Formula I are useful as ALK and JAK modulators for the treatment of proliferative disorders.

Abstract translation: 本申请涉及本文定义的式I化合物和/或其盐。 本申请还涉及使用这些化合物和/或其盐的组合物和方法。 式I的化合物可用作治疗增殖性疾病的ALK和JAK调节剂。