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公开(公告)号：US20170173017A1
公开(公告)日：2017-06-22
申请号：US15451960
申请日：2017-03-07
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier (deceased) , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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2.发明授权Fused bicyclic 2,4-diaminopyrimidine derivative as a dual ALK and FAK inhibitor 有权稠合双环2,4-二氨基嘧啶衍生物作为双重ALK和FAK抑制剂公开(公告)号：US09132128B2
公开(公告)日：2015-09-15
申请号：US14474928
申请日：2014-09-02
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506 , C07D403/04 , C07D403/12
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
Abstract translation: 本发明提供式（I）化合物或其盐形式。 式（I）化合物具有ALK和FAK抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：US09623026B2
公开(公告)日：2017-04-18
申请号：US15146164
申请日：2016-05-04
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506 , C07D403/04 , C07D403/12
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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公开(公告)号：US09339502B2
公开(公告)日：2016-05-17
申请号：US14824750
申请日：2015-08-12
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506 , C07D403/04 , C07D403/12
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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公开(公告)号：US20150011561A1
公开(公告)日：2015-01-08
申请号：US14474928
申请日：2014-09-02
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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Patent Agency Ranking
公开(公告)号：US20190328735A1
公开(公告)日：2019-10-31
申请号：US16172368
申请日：2018-10-26
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506 , C07D403/04
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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7.发明申请FUSED BICYCLIC 2,4-DIAMINOPYRIMIDINE DERIVATIVE AS A DUAL ALK AND FAK INHIBITOR 有权双金属双酚A衍生物双酚A和双酚A衍生物公开(公告)号：US20160243119A1
公开(公告)日：2016-08-25
申请号：US15146164
申请日：2016-05-04
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier (deceased) , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
Abstract translation: 本发明提供式（I）化合物或其盐形式。 式（I）化合物具有ALK和FAK抑制活性，可用于治疗增殖性疾病。
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![Solid State Forms of 6-[4-[3-((R)-2-Methylpyrrolidine-1-yl)-propoxy]phenyl] 2H-pyridazine-3-one Hydrochloride](/abs-image/US/2014/09/18/US20140275102A1/abs.jpg.150x150.jpg)
8.发明申请Solid State Forms of 6-[4-[3-((R)-2-Methylpyrrolidine-1-yl)-propoxy]phenyl] 2H-pyridazine-3-one Hydrochloride 审中-公开6- [4- [3 - （（R）-2-甲基吡咯烷-1-基） - 丙氧基]苯基] -2H-哒嗪-3-酮盐酸盐的固体形式公开(公告)号：US20140275102A1
公开(公告)日：2014-09-18
申请号：US14207465
申请日：2014-03-12
Applicant: Cephalon Inc.
Inventor： Stephen J. Bierlmaier , Laurent Courvoisier , Ralph C. Haltiwanger , Martin J. Jacobs
IPC: C07D403/12
CPC classification number: C07D403/12
Abstract: Solid state forms of the compound 6-[4-[3-((R)-2-methylpyrrolidine-1-yl)-propoxy]phenyl]2H-pyridazine-3-one hydrochloride (Compound 1), processes for preparing the solid state forms, and pharmaceutical compositions thereof, are provided. Compound 1 is a histamine H3 receptor antagonist/inverse agonist. Thus the provided solid state forms are useful, for example, for the manufacture of a medicament for the treatment of disorders mediated by the H3 receptor.
Abstract translation: 化合物6- [4- [3 - （（R）-2-甲基吡咯烷-1-基） - 丙氧基]苯基] -2H-哒嗪-3-酮盐酸盐（化合物1）的固体形式，制备固体的方法 状态及其药物组合物。 化合物1是组胺H3受体拮抗剂/反向激动剂。 因此，提供的固态形式可用于例如制备用于治疗由H3受体介导的病症的药物。
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公开(公告)号：US10150772B2
公开(公告)日：2018-12-11
申请号：US15529883
申请日：2015-11-25
Applicant: CEPHALON, INC.
Inventor： Stephen J. Bierlmaier , Ralph C. Haltiwanger , Martin J. Jacobs
IPC: C07D487/04 , C07C59/06 , C07C53/10 , C07C59/245 , C07D207/28 , C07C57/15
Abstract: The present disclosure relates to crystalline forms of 4,5,6,7-tetrahydro-11-methoxy-2-[(4-methyl-1-piperazinyl)methyl]-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione, including salts forms and free base forms.
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公开(公告)号：US10111872B2
公开(公告)日：2018-10-30
申请号：US15451960
申请日：2017-03-07
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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