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公开(公告)号：US20170173017A1
公开(公告)日：2017-06-22
申请号：US15451960
申请日：2017-03-07
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier (deceased) , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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2.发明授权Fused bicyclic 2,4-diaminopyrimidine derivative as a dual ALK and FAK inhibitor 有权稠合双环2,4-二氨基嘧啶衍生物作为双重ALK和FAK抑制剂公开(公告)号：US09132128B2
公开(公告)日：2015-09-15
申请号：US14474928
申请日：2014-09-02
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506 , C07D403/04 , C07D403/12
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
Abstract translation: 本发明提供式（I）化合物或其盐形式。 式（I）化合物具有ALK和FAK抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：US20150011561A1
公开(公告)日：2015-01-08
申请号：US14474928
申请日：2014-09-02
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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公开(公告)号：US09623026B2
公开(公告)日：2017-04-18
申请号：US15146164
申请日：2016-05-04
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506 , C07D403/04 , C07D403/12
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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公开(公告)号：US09339502B2
公开(公告)日：2016-05-17
申请号：US14824750
申请日：2015-08-12
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506 , C07D403/04 , C07D403/12
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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Patent Agency Ranking
公开(公告)号：US20130123499A1
公开(公告)日：2013-05-16
申请号：US13678886
申请日：2012-11-16
Applicant: Cephalon, Inc. , Cephalon France
Inventor： Shawn P. Allwein , Arnaud Grandeury , Guy Piacenza , Sebastien Rose
IPC: C07D487/14
CPC classification number: C07D487/14
Abstract: The present invention relates a method for purifying a fused pyrrolocarbazole compound known as 11-isobutyl-2-methyl-8-(2-pyrimidinylamino)-2,5,6,11,12,13-hexahydro-4Hindazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one using an acid complex thereof. The present invention also relates to a crystalline form of the acid complex.
Abstract translation: 本发明涉及一种纯化称为11-异丁基-2-甲基-8-（2-嘧啶基氨基）-2,5,6,11,12,13-六氢-4H-吲唑并[5,4-噻唑并[ a]吡咯并[3,4-c]咔唑-4-酮。 本发明还涉及酸络合物的结晶形式。
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公开(公告)号：US10111872B2
公开(公告)日：2018-10-30
申请号：US15451960
申请日：2017-03-07
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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8.发明申请Fused Bicyclic 2,4-diaminopyrimidine Derivative as a Dual ALK and FAK Inhibitor 有权稠合双环2,4-二氨基嘧啶衍生物作为双重ALK和FAK抑制剂公开(公告)号：US20150374693A1
公开(公告)日：2015-12-31
申请号：US14824750
申请日：2015-08-12
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506
CPC classification number: A61K31/506 , C07D403/04 , C07D403/12
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
Abstract translation: 本发明提供式（I）化合物或其盐形式。 式（I）化合物具有ALK和FAK抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：US20150368257A1
公开(公告)日：2015-12-24
申请号：US14831998
申请日：2015-08-21
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , George C. Morton , Gerard C. Rosse , Yi Wang
IPC: C07D491/052
CPC classification number: C07D491/052
Abstract: This application relates to tricyclic compounds of Formula I: including all stereoisomeric forms, all mixtures of stereoisomeric forms, and salts of these compounds. This application also relates to compositions comprising compounds of Formula I, stereoisomeric forms, all mixtures of stereoisomeric forms, and salts thereof and uses therefor.
Abstract translation: 本申请涉及式I的三环化合物：包括所有立体异构形式，立体异构形式的所有混合物和这些化合物的盐。 本申请还涉及包含式I化合物，立体异构形式，立体异构形式的所有混合物及其盐的组合物和用途。
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公开(公告)号：US20190328735A1
公开(公告)日：2019-10-31
申请号：US16172368
申请日：2018-10-26
Applicant: Cephalon, Inc.
Inventor： Shawn P. Allwein , Laurent Courvoisier , Martin J. Jacobs , Gregory R. Ott
IPC: A61K31/506 , C07D403/04
Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.
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