公开(公告)号：US20160095955A1

公开(公告)日：2016-04-07

申请号：US14821964

申请日：2015-08-10

申请人： Cerapedics, Inc.

发明人： James J. BENEDICT ,  Greg Allen BREWSTER ,  Donald Barclay FREEMAN

IPC分类号： A61L27/36 ,  A61L27/54 ,  A61L27/20

CPC分类号： A61L27/3608 ,  A61L27/20 ,  A61L27/28 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02 ,  C08L1/28

摘要： A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist environment of the body, it will hold its shape well, for an extended time. Because the lyophilized pliable medical device is porous, it adsorbs blood and other beneficial cells containing body fluids, such as bone marrow, contributing to its superior bone repair efficacy in comparison to an analogous putty that has not been lyophilized. In addition these lyophilized pliable medical devices are easier to terminally steam sterilize than the analogous putty because there is no moisture present to boil and ‘blow-out’ of the containment device (syringe). The glycerin that is present in the formulation lends pliability but has a low vapor pressure.

摘要翻译： 用作骨移植物替代物或骨移植物延长剂的牢固但柔韧的医疗装置保持其形状，而不需要诸如注射器的容纳装置。 因为该装置是固体，所以很容易在体内定位或定位，并且在身体的潮湿环境中，其将保持良好的形状，长时间。 因为冻干的柔韧的医疗装置是多孔的，因此与没有被冻干的类似的腻子相比，它吸收含有体液如骨髓的血液和其它有益细胞，有助于其优异的骨修复功效。 此外，这些冻干的柔韧的医疗设备比类似的油灰更容易终止蒸汽灭菌，因为没有水分存在，以使容器（注射器）沸腾和“吹出”。 存在于制剂中的甘油具有柔韧性但具有低蒸气压。