公开(公告)号：US20230145155A1

公开(公告)日：2023-05-11

申请号：US18050401

申请日：2022-10-27

Applicant: Cercacor Laboratories, Inc.

Inventor： Venkatramanan Krishnamani ,  Anando Devadoss

IPC: A61B5/1473 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61B5/1473 ,  A61B5/14532 ,  A61B5/4839 ,  A61B2562/028

Abstract: A disease management system including an microelectrochemical cell configured to be implanted into a patient. The microelectrochemical cell may include a tube which may include at least one sidewall, a closed end configured to be implanted in the patient, and open end configured to receive a feedthrough for at least one electrode lead. The microelectrochemical cell may further include a fluid medium in fluid communication with bodily fluid, an analyte sensor configured to measure at least one analyte within the bodily fluid, and at least one electrical connection to the analyte sensor at the feedthrough.

公开(公告)号：US20240016418A1

公开(公告)日：2024-01-18

申请号：US18352742

申请日：2023-07-14

Applicant: Cercacor Laboratories, Inc.

Inventor： Anando Devadoss ,  Venkatramanan Krishnamani ,  Qiurong Shi ,  David Shimomoto ,  Ngoc Nhu Ly

IPC: A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/14532 ,  A61B5/1486

Abstract: The present disclosure provides devices, systems, and methods capable of optimizing in vivo electrochemical measurement of a molecule of interest, for example glucose. Disclosed aspects may include an interference zapping layer, to which an electric potential may be applied to prevent or minimize various interfering molecules from reaching a working electrode. Aspects of the present disclosure may additionally or alternatively include a sensor including multiple working electrodes. The sensors having multiple working electrodes may measure background current during sensing in order to determine background current specific to each electrode, current due to electrochemical interferents, and current due to the molecule of interest. Sensors may also be capable of executing a measurement mode whereby a plurality of currents are measured over a range of interference zapping layer potentials and a range of working electrode potentials.

公开(公告)号：US20240016419A1

公开(公告)日：2024-01-18

申请号：US18352850

申请日：2023-07-14

Applicant: Cercacor Laboratories, Inc.

Inventor： Anando Devadoss ,  Venkatramanan Krishnamani

IPC: A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/14532 ,  A61B5/1486

Abstract: Aspects of the present disclosure provide devices and methods capable of optimizing in vivo electrochemical measurement of a molecule of interest, for example glucose. Such aspects may include an engineered binding protein, for example an engineered glucose binding protein. The engineered binding protein may change conformation in response to binding or unbinding to a ligand and/or analyte, for example glucose. Such conformational changes may either expose or occlude a redox molecule attached to the binding protein. When exposed, the redox molecule may generate a redox signal dependent upon the binding protein's conformational state. The redox signal may be measurable, for example by cyclic voltammetry. The protein may be incorporated into a sensor that can be used as an implantable continuous glucose monitoring device.

公开(公告)号：US20230389837A1

公开(公告)日：2023-12-07

申请号：US18143469

申请日：2023-05-04

Applicant: Cercacor Laboratories, Inc.

Inventor： Venkatramanan Krishnamani ,  Anando Devadoss ,  Sahand Pirbadian ,  Nan Hu

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532

Abstract: A physiological sensor system that may include an analyte sensor configured to measure at least one analyte at varying depths at a tissue site of a user. The analyte sensor may include a plurality of electrodes patterned on a semi-rigid substrate meant to penetrate the skin of a user. The substrate may be varying lengths to increase the number of electrodes at the penetration site of the user and decrease the likelihood of a bad reading due to poor placement of the electrodes. The electrodes may be patterned on both sides of the substrate to increase number of measurement sites. The analyte sensor can be positioned in an electrochemical cell disposed in the body of the user.

公开(公告)号：US20220151521A1

公开(公告)日：2022-05-19

申请号：US17528630

申请日：2021-11-17

Applicant: Cercacor Laboratories, Inc.

Inventor： Venkatramanan Krishnamani ,  Sahand Pirbadian ,  Kevin Hughes Pauley ,  Sergei Petrovich Balashov ,  Anando Devadoss

IPC: A61B5/145 ,  G16H20/17 ,  A61B5/1486 ,  G01N27/327

Abstract: Embodiments of the present disclosure relate to a temperature independent glucose sensor and methods of making the same. Such glucose monitoring device may comprise a working electrode, a reference electrode, an glucose oxidase containing enzymatic layer, a first permeability-selective layer, an oxygen-replenishing layer, and an outer protective layer. Additional embodiments relate to a glucose sensor having an enzymatic layer containing glucose oxidase and a polymeric mediator. The sensors may be used as an implantable continuous glucose monitoring device without the need of a temperature sensor.