公开(公告)号：US12214092B2

公开(公告)日：2025-02-04

申请号：US18084344

申请日：2022-12-19

Applicant: Cerus Corporation

Inventor： Daniel Church ,  Peter Bringmann ,  Grace Castro ,  Thea Lu ,  Shelby Reinhardt ,  Felicia Santa Maria ,  Adonis Stassinopoulos

IPC: A61L2/00 ,  A01N1/02 ,  A61K31/37 ,  A61K41/17 ,  A61L2/26 ,  A61M1/36 ,  B01J19/12 ,  H01L25/075 ,  A61L2/24

Abstract: Provided are systems and methods for treating a biological fluid, e.g., to inactivate pathogens.

公开(公告)号：US10688166B2

公开(公告)日：2020-06-23

申请号：US15524233

申请日：2015-11-02

Applicant: CERUS CORPORATION

Inventor： Adonis Stassinopoulos ,  William Mariner Greenman

IPC: A61K39/00 ,  A61K35/17 ,  C12N5/0783 ,  A61P35/00 ,  A61K9/00 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  A61K38/00

Abstract: The present invention relates to the preparation and use in recipients of CAR-T cell-derived effector cells which are modified to limit their proliferation within the recipient. This is accomplished through the introduction of adducts into the nucleic acids of CAR-T cell-derived effector cells following expansion in vitro to provide expanded and activated CAR-T cell-derived effector cells that retain immunologic function, including the expression of one ore more cytokines.

公开(公告)号：US11554185B2

公开(公告)日：2023-01-17

申请号：US16236193

申请日：2018-12-28

Applicant: Cerus Corporation

Inventor： Daniel Church ,  Peter Bringmann ,  Grace Castro ,  Thea Lu ,  Shelby Reinhardt ,  Felicia Santa Maria ,  Adonis Stassinopoulos

IPC: A61L2/00 ,  A61M1/36 ,  A61L2/26 ,  A61K31/37 ,  A01N1/02 ,  B01J19/12 ,  H01L25/075 ,  A61K41/17 ,  A61L2/24

Abstract: Provided are systems and methods for treating a biological fluid, e.g., to inactivate pathogens.