公开(公告)号：US20240189462A1

公开(公告)日：2024-06-13

申请号：US18534521

申请日：2023-12-08

Applicant: TWENTY TWENTY THERAPEUTICS LLC

Inventor： Timothy Stowe

IPC: A61L2/00 ,  A61F9/00 ,  A61K9/08 ,  A61K41/17 ,  A61L2/26

CPC classification number: A61L2/0076 ,  A61F9/0008 ,  A61K9/08 ,  A61K41/17 ,  A61L2/0047 ,  A61L2/26 ,  A61L2202/11 ,  A61L2202/121 ,  A61L2202/122 ,  A61L2202/21

Abstract: A sterilizing fluid dispenser cartridge is described. The cartridge includes a reservoir configured to retain an aqueous fluid comprising an exogenic sterilizing light absorber; a dispensing head comprising a nozzle; and a polymeric nozzle cover movably coupled to the dispensing head. At least a region of the fluid dispenser cartridge is partially transparent. The fluid dispenser cartridge can be used as part of a fluid dispensing system, and methods of administering a sterilized aqueous fluid are also described.

公开(公告)号：US20230248795A1

公开(公告)日：2023-08-10

申请号：US18102554

申请日：2023-01-27

Applicant: Botanic Tonics, LLC

Inventor： Jerry Wayne Ross

IPC: A61K36/67 ,  A61K31/366 ,  A61K36/74 ,  A61K31/4375 ,  A61K9/16 ,  A61K41/17

CPC classification number: A61K36/67 ,  A61K31/366 ,  A61K36/74 ,  A61K31/4375 ,  A61K9/1688 ,  A61K41/17 ,  A61K2236/15 ,  A61K2236/53 ,  A61K2236/17

Abstract: Kava and kratom compositions are described herein along with the methods of producing the same. The description contained herein describes methods for making a purified kava composition that is free or substantially free of flavokavain A and flavokavain B. In some embodiments, the kava composition is formulated as a ready-to-drink beverage. Certain compositions comprise a combination of a kava composition and a kratom composition made in accordance with the methods described herein.

公开(公告)号：US20230094393A1

公开(公告)日：2023-03-30

申请号：US17759594

申请日：2021-02-05

Applicant: Elektrofi, Inc.

Inventor： Lyndon Fitzgerald Charles ,  Chase Spenser Coffman ,  Daniel Benjamin Dadon ,  Chaitanya Sudrik

IPC: A61K9/16 ,  A61K38/03 ,  A61K41/17

Abstract: The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles comprising biologically active peptides.

公开(公告)号：US20230022419A1

公开(公告)日：2023-01-26

申请号：US17797470

申请日：2021-02-03

Applicant: KOREA ATOMIC ENERGY RESEARCH INSTITUTE

Inventor： Sang-Hyun PARK ,  Muhammad Asim RAZA

IPC: A61K9/06 ,  A61K31/7036 ,  A61K31/43 ,  A61K51/06 ,  A61K41/17 ,  A61K47/36 ,  A61K47/24 ,  A61K47/32

Abstract: The present disclosure provides a hydrogel having excellent drug delivery ability and having antibacterial properties as well as pH-dependent, biocompatible and biodegradable properties, and a method for preparing the same. The hydrogel including radiated chitosan, a natural gelling polymer, a hydrophilic synthetic polymer and (3-mercaptopropyl)trimethoxysilane (MPTMS), and the method for preparing the same are provided.

公开(公告)号：US20220347207A1

公开(公告)日：2022-11-03

申请号：US17855435

申请日：2022-06-30

Applicant: Azura Ophthalmics Ltd.

Inventor： Hila EPSTEIN-BARASH ,  Shimon NAHUM ,  Shimon AMSELEM ,  Yair ALSTER

IPC: A61K33/04 ,  A61K41/17 ,  A61K9/06 ,  A61K47/06 ,  A61K47/44 ,  A61K47/14 ,  A61K47/34 ,  A61K47/12

Abstract: Described herein are methods for the manufacture of compositions useful for the treatment of meibomian gland dysfunction. Said methods utilize rheological properties of petrolatum induced by a high shear mixing feature of the method. The products of the methods of manufacture described herein are stable anhydrous composition of selenium disulfide which are substantially free of selenium disulfide agglomerates and degradation products.

公开(公告)号：US20220226234A1

公开(公告)日：2022-07-21

申请号：US17614881

申请日：2020-05-29

Applicant: LG CHEM, LTD.

Inventor： Sung Won KIM ,  Jae Uk BAEK ,  Hyun Seo PARK ,  Myung Won JIN ,  Jung Gyu PARK ,  Bok Tae KIM ,  Sei Hyun CHOI

IPC: A61K9/00 ,  A61K31/4725 ,  A61K9/16 ,  A61K9/19 ,  A61K41/17

Abstract: The present invention relates to an injectable pharmaceutical composition containing a prodrug of caspase inhibitors, and a preparation method therefor. More specifically, the present invention relates to an injectable pharmaceutical composition, and a preparation method therefor, the composition comprising, as an active ingredient, (2S,3S)-2-(fluoromethyl)-3-((R)-5-isopropyl-3-(isoquinolin-1-yl)-4,5-dihydroisoxazole-5-carboxamido)-5-oxotetrahydrofuran-2-yl acetate, which is a prodrug of caspase inhibitors, or a pharmaceutically acceptable salt or isomer thereof, and comprising, as a biocompatible polymer, microspheres containing poly(lactide-co-glycolide).

公开(公告)号：US20220096507A1

公开(公告)日：2022-03-31

申请号：US17423210

申请日：2021-06-29

Applicant: Sandoz AG

Inventor： Arpad Toldy ,  Eva Littringer ,  Katri Rouvali Oberer

IPC: A61K31/706 ,  A61K47/20 ,  A61K9/00 ,  A61K41/17 ,  A61K9/08

Abstract: The invention relates to a parenteral pharmaceutical composition comprising azacitidine and dimethyl sulfoxide.

公开(公告)号：US11219677B2

公开(公告)日：2022-01-11

申请号：US15970540

申请日：2018-05-03

Applicant: Rosalind Franklin Univ. of Medicine and Science

Inventor： Kwang-Poo Chang ,  Laura Manna ,  Raffaele Corso ,  Bala K. Kolli

IPC: A61K39/008 ,  A61K41/00 ,  A61K41/17 ,  A61K39/00

Abstract: The present invention provides a method for treating canine leishmaniasis by immunotherapy.

公开(公告)号：US20220001013A1

公开(公告)日：2022-01-06

申请号：US17482846

申请日：2021-09-23

Applicant: Hemanext Inc.

Inventor： Samuel O. SOWEMIMO-COKER ,  Jeffrey SUTTON ,  Tatsuro YOSHIDA

IPC: A61K41/17 ,  A61L2/00 ,  A61K35/18

Abstract: A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles.

公开(公告)号：US11135445B2

公开(公告)日：2021-10-05

申请号：US16277191

申请日：2019-02-15

Applicant: The General Hospital Corporation

Inventor： Daniela Vecchio ,  Michael R. Hamblin ,  Yingying Huang ,  Liyi Huang ,  Giacomo Landi ,  Jeffrey A. Gelfand ,  Timothy Brauns

IPC: A61N5/06 ,  A61B18/24 ,  A61K41/00 ,  A61K41/17 ,  A61K31/045 ,  A61K31/43 ,  G02B23/26

Abstract: A problem of incomplete inhibition of harmful cells/bacteria and short duration of time, after the photodynamic treatment, during which such cells may re-grow, is solved by exposing the target bacteria with a multi-component photosensitizer material formed by adding a predetermined potentiating chemical to a conventional single-component photosensitizer at the target, prior to irradiating the target with light. The multi-component photosensitizer is effectuated by forming a mix of the two chemical compositions or by sequential exposure of the bacteria to a single-component photosensitizer and the potentiating chemical of choice.