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    Nanostructures Suitable for Sequestering Cholesterol and Other Molecules
    4.
    发明申请
    Nanostructures Suitable for Sequestering Cholesterol and Other Molecules 有权
    适用于螯合胆固醇和其他分子的纳米结构

    公开(公告)号：US20090324706A1

    公开(公告)日：2009-12-31

    申请号：US12429560

    申请日：2009-04-24

    申请人： Chad A. Mirkin ,  C. Shad Thaxton ,  David A. Giljohann ,  Weston Daniel

    发明人： Chad A. Mirkin ,  C. Shad Thaxton ,  David A. Giljohann ,  Weston Daniel

    IPC分类号： A61K9/127 ,  A61K31/7088 ,  A61P9/10

    CPC分类号： A61K9/127 ,  A61K9/1271 ,  A61K9/1275 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/7088

    摘要： Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels.

    摘要翻译： 提供了与纳米结构相关的制品，组合物，试剂盒和方法，包括可以螯合分子如胆固醇的物质，组合物，试剂盒和方法。 本文描述的某些实施例包括具有核 - 壳型布置的结构; 例如，纳米颗粒核心可以被包含可与胆固醇和/或其他脂质相互作用的材料（例如脂质双层）的壳包围。 在一些实施方案中，当引入受试者时，结构可以螯合胆固醇和/或其它脂质并将其从循环中除去。 因此，本文所述的结构可用于诊断，预防，治疗或管理某些疾病或身体状况，特别是与异常脂质水平相关的疾病或身体状况。

    Nanostructures suitable for sequestering cholesterol and other molecules
    5.
    发明授权
    Nanostructures suitable for sequestering cholesterol and other molecules 有权
    适用于螯合胆固醇和其他分子的纳米结构

    公开(公告)号：US08323686B2

    公开(公告)日：2012-12-04

    申请号：US12429560

    申请日：2009-04-24

    申请人： Chad A. Mirkin ,  C. Shad Thaxton ,  David A. Giljohann ,  Weston Daniel

    发明人： Chad A. Mirkin ,  C. Shad Thaxton ,  David A. Giljohann ,  Weston Daniel

    IPC分类号： A61K9/127 ,  A61K9/14

    CPC分类号： A61K9/127 ,  A61K9/1271 ,  A61K9/1275 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/7088

    摘要： Articles, compositions, kits and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids, and an apolipoprotein may be bound to at least the outer surface of the shell. In some embodiments, the structures, when introduced to a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels.

    摘要翻译： 提供了与纳米结构相关的制品，组合物，试剂盒和方法，包括可以螯合分子如胆固醇的物质，组合物，试剂盒和方法。 本文描述的某些实施例包括具有核 - 壳型布置的结构; 例如，纳米颗粒核心可以被包含可与胆固醇和/或其它脂质相互作用的材料（例如脂质双层）的壳包围，并且载脂蛋白可以结合至壳的至少外表面。 在一些实施方案中，当引入受试者时，结构可以螯合胆固醇和/或其它脂质并将其从循环中除去。 因此，本文所述的结构可用于诊断，预防，治疗或管理某些疾病或身体状况，特别是与异常脂质水平相关的疾病或身体状况。

    Nanostructures Suitable for Sequestering Cholesterol and Other Molecules
    6.
    发明申请
    Nanostructures Suitable for Sequestering Cholesterol and Other Molecules 有权
    适用于螯合胆固醇和其他分子的纳米结构

    公开(公告)号：US20110059156A9

    公开(公告)日：2011-03-10

    申请号：US12429560

    申请日：2009-04-24

    申请人： Chad A. Mirkin ,  C. Shad Thaxton ,  David A. Giljohann ,  Weston Daniel

    发明人： Chad A. Mirkin ,  C. Shad Thaxton ,  David A. Giljohann ,  Weston Daniel

    IPC分类号： A61K9/127 ,  A61K31/7088 ,  A61P9/10

    CPC分类号： A61K9/127 ,  A61K9/1271 ,  A61K9/1275 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/7088

    摘要： Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels.

    摘要翻译： 提供了与纳米结构相关的制品，组合物，试剂盒和方法，包括可以螯合分子如胆固醇的物质，组合物，试剂盒和方法。 本文描述的某些实施例包括具有核 - 壳型布置的结构; 例如，纳米颗粒核心可以被包含可与胆固醇和/或其他脂质相互作用的材料（例如脂质双层）的壳包围。 在一些实施方案中，当引入受试者时，结构可以螯合胆固醇和/或其它脂质并将其从循环中除去。 因此，本文所述的结构可用于诊断，预防，治疗或管理某些疾病或身体状况，特别是与异常脂质水平相关的疾病或身体状况。

    BIO-BARCODE BASED DETECTION OF TARGET ANALYTES
    9.
    发明申请
    BIO-BARCODE BASED DETECTION OF TARGET ANALYTES 审中-公开
    基于BIO-BARCODE的目标分析检测

    公开(公告)号：US20100081134A1

    公开(公告)日：2010-04-01

    申请号：US12348909

    申请日：2009-01-05

    申请人： Chad A. Mirkin ,  Jwa-Min Nam ,  C. Shad Thaxton

    发明人： Chad A. Mirkin ,  Jwa-Min Nam ,  C. Shad Thaxton

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/58 ,  C12Q1/6816 ,  C12Q2563/179

    摘要： The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or other target analytes in a solution.

    摘要翻译： 本发明涉及用于检测一种或多种目标分析物的存在或不存在的筛选方法，组合物和试剂盒，例如， 生物分子。 特别地，本发明涉及利用报告寡核苷酸作为检测多种蛋白质结构或溶液中其它目标分析物的生化条形码的方法。