公开(公告)号：US20090317469A1

公开(公告)日：2009-12-24

申请号：US12488996

申请日：2009-06-22

申请人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

发明人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

IPC分类号： A61K9/10

CPC分类号： A61L27/56 ,  A61L27/3633

摘要： Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non-expanded collagenous materials. Methods for their preparation and use are also disclosed. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

摘要翻译： 在某些方面描述的是复合细胞外基质材料产品，包括扩张的胶原材料与非扩张胶原材料的组合。 还公开了其制备和使用方法。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。 扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

公开(公告)号：US20090318934A1

公开(公告)日：2009-12-24

申请号：US12488974

申请日：2009-06-22

申请人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

发明人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

IPC分类号： A61B17/28 ,  A61K9/00 ,  A61K38/18

摘要： Described are expanded collagenous materials useful in hemostatic applications. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, recovering the expanded material, processing the expanded material to provide a foam, and chemically crosslinking the foam. Expanded materials can exhibit beneficial resilience, persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

摘要翻译： 描述了可用于止血应用的扩张胶原材料。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下处理具有碱性物质的第一胶原材料，回收膨胀的材料，加工膨胀的材料以提供泡沫和化学交联泡沫来制备。 膨胀的材料可以在植入时显示出有益的弹性，持续性和组织生成特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

公开(公告)号：US08741354B2

公开(公告)日：2014-06-03

申请号：US12488996

申请日：2009-06-22

申请人： Chad E. Johnson ,  David M. J. Ernst ,  Amy Overby

发明人： Chad E. Johnson ,  David M. J. Ernst ,  Amy Overby

IPC分类号： A61K9/14 ,  A61K35/37 ,  A61K38/18 ,  A61K38/00

CPC分类号： A61L27/56 ,  A61L27/3633

摘要： Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non-expanded collagenous materials. Methods for their preparation and use are also disclosed. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

摘要翻译： 在某些方面描述的是复合细胞外基质材料产品，包括扩张的胶原材料与非扩张胶原材料的组合。 还公开了其制备和使用方法。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。 扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

公开(公告)号：US20110093088A1

公开(公告)日：2011-04-21

申请号：US12938474

申请日：2010-11-03

申请人： Steve Chen ,  Ryan Dempsey ,  Jeffrey Miller ,  Amy Overby

发明人： Steve Chen ,  Ryan Dempsey ,  Jeffrey Miller ,  Amy Overby

IPC分类号： A61F2/02 ,  A61M5/32

CPC分类号： A61F2/0059 ,  A61B17/3468 ,  A61B2017/00792 ,  A61B2017/00862 ,  A61B2017/00969 ,  A61B2017/061 ,  A61F2/0077

摘要： Described, in certain inventive embodiments, are unique devices and methods for introducing implants into soft tissue of a patient. One of these devices includes a tissue-penetrating member that is configured to pass in its entirety through a volume of patient tissue. The tissue-penetrating member has a leading end and a trailing end, and provides a receiving space for receipt of an implant body portion for carrying the implant body portion into the volume of patient tissue. The device also includes an implant that has an implant body portion removably received in the receiving space of the tissue-penetrating member. The implant body portion is configured for deployment from the receiving space in the volume of patient tissue so as to remain deployed there along a passageway traversed by the tissue-penetrating member.

摘要翻译： 在某些发明实施例中描述了用于将植入物引入患者的软组织中的独特装置和方法。 这些装置中的一个包括组织穿透构件，所述组织穿透构件被构造成整体穿过患者组织的体积。 组织穿透构件具有前端和后端，并且提供用于接收用于将植入物主体部分携带到患者组织体积中的植入物主体部分的接收空间。 该装置还包括植入物，其具有可拆卸地容纳在组织穿透构件的容纳空间中的植入物主体部分。 植入物主体部分构造成从患者组织体积中的接收空间展开，以便沿着由组织穿透构件穿过的通道保持展开。

公开(公告)号：US08652216B2

公开(公告)日：2014-02-18

申请号：US12938474

申请日：2010-11-03

申请人： Steve Chen ,  Ryan Dempsey ,  Jeffrey Miller ,  Amy Overby

发明人： Steve Chen ,  Ryan Dempsey ,  Jeffrey Miller ,  Amy Overby

IPC分类号： A61F2/02

CPC分类号： A61F2/0059 ,  A61B17/3468 ,  A61B2017/00792 ,  A61B2017/00862 ,  A61B2017/00969 ,  A61B2017/061 ,  A61F2/0077

摘要： Described, in certain inventive embodiments, are unique devices and methods for introducing implants into soft tissue of a patient. One of these devices includes a tissue-penetrating member that is configured to pass in its entirety through a volume of patient tissue. The tissue-penetrating member has a leading end and a trailing end, and provides a receiving space for receipt of an implant body portion for carrying the implant body portion into the volume of patient tissue. The device also includes an implant that has an implant body portion removably received in the receiving space of the tissue-penetrating member. The implant body portion is configured for deployment from the receiving space in the volume of patient tissue so as to remain deployed there along a passageway traversed by the tissue-penetrating member.

摘要翻译： 在某些发明实施例中描述了用于将植入物引入患者的软组织中的独特装置和方法。 这些装置中的一个包括组织穿透构件，所述组织穿透构件被构造成整体穿过患者组织的体积。 组织穿透构件具有前端和后端，并且提供用于接收用于将植入物主体部分携带到患者组织体积中的植入物主体部分的接收空间。 该装置还包括植入物，其具有可拆卸地容纳在组织穿透构件的容纳空间中的植入物主体部分。 植入物主体部分构造成从患者组织体积中的接收空间展开，以便沿着由组织穿透构件穿过的通道保持展开。