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    COMPOSITE EXTRACELLULAR MATRIX MATERIALS AND MEDICAL PRODUCTS FORMED THEREFROM
    1.
    发明申请
    COMPOSITE EXTRACELLULAR MATRIX MATERIALS AND MEDICAL PRODUCTS FORMED THEREFROM 有权
    复合细胞基质材料和形成的医药产品

    公开(公告)号：US20090317469A1

    公开(公告)日：2009-12-24

    申请号：US12488996

    申请日：2009-06-22

    申请人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

    发明人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

    IPC分类号： A61K9/10

    CPC分类号： A61L27/56 ,  A61L27/3633

    摘要： Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non-expanded collagenous materials. Methods for their preparation and use are also disclosed. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

    摘要翻译： 在某些方面描述的是复合细胞外基质材料产品，包括扩张的胶原材料与非扩张胶原材料的组合。 还公开了其制备和使用方法。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。 扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

    COMPRESSIBLE/EXPANDABLE MEDICAL GRAFT PRODUCTS, AND METHODS FOR APPLYING HEMOSTASIS
    2.
    发明申请
    COMPRESSIBLE/EXPANDABLE MEDICAL GRAFT PRODUCTS, AND METHODS FOR APPLYING HEMOSTASIS 审中-公开
    可压缩/可扩展的医用产品，以及应用HEMOSTASIS的方法

    公开(公告)号：US20090318934A1

    公开(公告)日：2009-12-24

    申请号：US12488974

    申请日：2009-06-22

    申请人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

    发明人： Chad E. Johnson ,  David M.J. Ernst ,  Amy Overby

    IPC分类号： A61B17/28 ,  A61K9/00 ,  A61K38/18

    摘要： Described are expanded collagenous materials useful in hemostatic applications. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, recovering the expanded material, processing the expanded material to provide a foam, and chemically crosslinking the foam. Expanded materials can exhibit beneficial resilience, persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

    摘要翻译： 描述了可用于止血应用的扩张胶原材料。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下处理具有碱性物质的第一胶原材料，回收膨胀的材料，加工膨胀的材料以提供泡沫和化学交联泡沫来制备。 膨胀的材料可以在植入时显示出有益的弹性，持续性和组织生成特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

    PHYSICALLY MODIFIED EXTRACELLULAR MATRIX MATERIALS AND USES THEREOF
    3.
    发明申请
    PHYSICALLY MODIFIED EXTRACELLULAR MATRIX MATERIALS AND USES THEREOF 有权
    物理改性的细胞基质材料及其用途

    公开(公告)号：US20090326577A1

    公开(公告)日：2009-12-31

    申请号：US12489199

    申请日：2009-06-22

    申请人： Chad E. Johnson ,  David M.J. Ernst ,  Michael Hiles ,  F. Joseph Obermiller

    发明人： Chad E. Johnson ,  David M.J. Ernst ,  Michael Hiles ,  F. Joseph Obermiller

    IPC分类号： A61B17/12 ,  A61F2/04

    CPC分类号： A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00641 ,  A61B2017/00654

    摘要： Described are expanded collagenous materials and methods for their preparation and use. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

    摘要翻译： 描述了扩张的胶原材料及其制备和使用的方法。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。 扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

    Composite extracellular matrix materials and medical products formed therefrom
    4.
    发明授权
    Composite extracellular matrix materials and medical products formed therefrom 有权
    复合细胞外基质材料和由此形成的医疗产品

    公开(公告)号：US08741354B2

    公开(公告)日：2014-06-03

    申请号：US12488996

    申请日：2009-06-22

    申请人： Chad E. Johnson ,  David M. J. Ernst ,  Amy Overby

    发明人： Chad E. Johnson ,  David M. J. Ernst ,  Amy Overby

    IPC分类号： A61K9/14 ,  A61K35/37 ,  A61K38/18 ,  A61K38/00

    CPC分类号： A61L27/56 ,  A61L27/3633

    摘要： Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non-expanded collagenous materials. Methods for their preparation and use are also disclosed. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

    摘要翻译： 在某些方面描述的是复合细胞外基质材料产品，包括扩张的胶原材料与非扩张胶原材料的组合。 还公开了其制备和使用方法。 某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。 扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

    Methods For Producing ECM-Based Biomaterials
    5.
    发明申请
    Methods For Producing ECM-Based Biomaterials 有权
    生产基于ECM的生物材料的方法

    公开(公告)号：US20110150998A1

    公开(公告)日：2011-06-23

    申请号：US12644607

    申请日：2009-12-22

    申请人： Laura-Lee Farrell ,  Chad E. Johnson

    发明人： Laura-Lee Farrell ,  Chad E. Johnson

    IPC分类号： A61K9/14 ,  B29C41/04 ,  A61P17/02

    CPC分类号： A61K9/0087 ,  A61K38/39 ,  A61L27/3633 ,  A61L31/005 ,  B29C39/08 ,  B29C67/20

    摘要： A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid medium, including at least one population of expanded ECM particles. The ECM composition is combined in a fluid medium to form a flowable ECM composition. The flowable ECM composition is subjected to a centrifugal force in a mold for a period of time sufficient to distribute the ECM particles according to differences in their physical characteristics. The ECM composition is dried to form a dried ECM material having a density gradient extending from a less dense region to a more dense region. The dried ECM material may formed as a porous, substantially acellular ECM material expandable in an aqueous fluid environment by at least 100% in volume.

    摘要翻译： 用于形成细胞外基质材料（ECM）材料的方法包括提供至少一种含有ECM颗粒的ECM组合物，其中ECM颗粒的能力通过流体介质（包括至少一个扩展的ECM颗粒群体）迁移。 ECM组合物在流体介质中组合以形成可流动的ECM组合物。 可流动的ECM组合物在模具中经受足够的离心力足以根据它们的物理特性的差异分布ECM颗粒。 将ECM组合物干燥以形成具有从较不密集区域延伸至更致密区域的密度梯度的干燥的ECM材料。 干燥的ECM材料可以形成为在水性流体环境中可膨胀至少100体积的多孔，基本上无细胞的ECM材料。

    Remodelable Prosthetic Valve
    6.
    发明申请
    Remodelable Prosthetic Valve 有权
    可重塑假肢瓣膜

    公开(公告)号：US20090138078A1

    公开(公告)日：2009-05-28

    申请号：US12273284

    申请日：2008-11-18

    申请人： Ram H. Paul, JR. ,  Sean D. Chambers ,  Chad E. Johnson

    发明人： Ram H. Paul, JR. ,  Sean D. Chambers ,  Chad E. Johnson

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2230/0026 ,  A61F2230/0095 ,  A61F2250/0031

    摘要： Prosthetic medical devices with delayed valve function and in situ remodeling of a portion thereof are provided, as well as methods of manufacturing the medical devices and methods of treatment using the medical devices. The medical devices may be adapted to initially maintain a remodelable material within a body vessel in a first configuration suitable to contact the remodelable material with a body fluid contacting the remodelable material for a first time period or a second configuration adapted to regulate the flow of body fluid contacting the remodelable material. The medical devices may include a releasable holding member configured to retain the remodelable material in the first configuration.

    摘要翻译： 提供具有延迟阀功能和其一部分的原位重塑的假体医疗装置，以及制造医​​疗装置的方法和使用医疗装置的治疗方法。 医疗装置可以适于以适于使可重塑材料接触第一时间段接触可重塑材料的体液或适于调节身体流动的第二构型的第一构型在体体容器内最初维持可重塑材料 液体接触可重塑材料。 医疗装置可以包括被配置为将可重塑材料保持在第一构造中的可释放保持构件。

    Devices and methods for treating fistulae and other bodily openings and passageways
    10.
    发明授权
    Devices and methods for treating fistulae and other bodily openings and passageways 有权
    用于治疗瘘管和其他身体开口和通道的装置和方法

    公开(公告)号：US09474514B2

    公开(公告)日：2016-10-25

    申请号：US13247156

    申请日：2011-09-28

    申请人： Charles W. Agnew ,  Mark Duncan ,  Chad E. Johnson

    发明人： Charles W. Agnew ,  Mark Duncan ,  Chad E. Johnson

    IPC分类号： A61B17/08 ,  A61B17/00 ,  A61B17/12

    CPC分类号： A61B17/0057 ,  A61B17/12099 ,  A61B17/12159 ,  A61B17/12181 ,  A61B17/1219 ,  A61B2017/00004 ,  A61B2017/00579 ,  A61B2017/00601 ,  A61B2017/00628 ,  A61B2017/00641 ,  A61B2017/0065 ,  A61B2017/00884

    摘要： Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.

    摘要翻译： 本发明的一些方面涉及用于治疗瘘管和身体其它通道和开口的独特产品和方法。 在一些优选形式中，本发明的构造将包括结合有多个片状或片状片段的细长移植体。 在一些布置中，多个片状或片状片段将沿着插塞体的长度沿大致纵向的方向堆叠，并且可选地，片段将被接收在一个或多个细长元件上。 这种细长的元件可以采取各种形式，包括缝合线，丝线，细丝或其他相对细长的细长构件，尽管在某些形式中，细长元件将是或包括一些较高的结构，例如可生物降解的或不可生物降解的 可生物降解的三维体。