公开(公告)号：US20060110370A1

公开(公告)日：2006-05-25

申请号：US10996156

申请日：2004-11-23

申请人： Chandrashenkhar Pathak ,  Mark Moore ,  Charles Simpson ,  Thomas Simpson ,  Sallie McLaughlin

发明人： Chandrashenkhar Pathak ,  Mark Moore ,  Charles Simpson ,  Thomas Simpson ,  Sallie McLaughlin

IPC分类号： A61K35/12 ,  A01N1/02

CPC分类号： A61L27/24 ,  A01N1/0231 ,  A01N63/00 ,  A61L2/0088 ,  A61L27/3687 ,  A61L27/56

摘要： A method for treating biomaterial is provided in which a biological tissue, typically after being cross-linked, is contacted with an anticalcification treatment solution under condition effective to render the biomaterial resistant to in vivo calcification upon implantation in a host animal. The anticalcification treatment solutions comprise higher alcohol solutions, a polyol solutions and/or a polar aprotic organic solvent solutions. Methods of reducing cytotoxicity to host tissue of bioprostheses that comprise fixed animal tissues, and treatments to reduce viral contamination of implantable medical devices are disclosed herein.

摘要翻译： 提供了一种治疗生物材料的方法，其中通常在交联后的生物组织在有效使得生物材料在植入宿主动物体内抵抗体内钙化的条件下与抗细胞治疗溶液接触。 抗化学处理溶液包含高级醇溶液，多元醇溶液和/或极性非质子有机溶剂溶液。 本文公开了减少包含固定动物组织的生物假体的宿主组织的细胞毒性的方法以及用于减少可植入医疗装置的病毒污染的治疗方法。