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6 条记录 (耗时 0.079 秒)

    Method of predicting drug-food interaction
    2.
    发明授权
    Method of predicting drug-food interaction 失效
    预测药物 - 食物相互作用的方法

    公开(公告)号：US07097967B2

    公开(公告)日：2006-08-29

    申请号：US10280587

    申请日：2002-10-24

    申请人： Aeri Kim ,  Kwan Hyung Cho ,  Sun Hwa Lee ,  Suk Kyoon Yoon ,  Hee Dong Park ,  Kyung Ha Chung ,  Ho Jun Kim ,  Han Joo Maeng ,  Tae Hun Kim ,  Bong Chan Kim ,  Sung Ji Kim

    发明人： Aeri Kim ,  Kwan Hyung Cho ,  Sun Hwa Lee ,  Suk Kyoon Yoon ,  Hee Dong Park ,  Kyung Ha Chung ,  Ho Jun Kim ,  Han Joo Maeng ,  Tae Hun Kim ,  Bong Chan Kim ,  Sung Ji Kim

    IPC分类号： C12Q1/00

    CPC分类号： C12Q1/37

    摘要： The present invention provides a method of predicting a food-drug interaction in vivo, in the case of an orally administered drug interactive with digestive enzymes in the gastrointestinal tract, by measuring the activity of the drug to the digestive enzymes in vitro, which is based on the fact that the ingestion of foods causes the absorption of drug in vivo to decrease due to the above interaction between a drug and digestive enzymes. The present invention further provides methods of minimizing the change of absorption in vivo caused by the ingestion of foods by reducing the action of digestive enzymes, for example, introduction of prodrugs, modification of the chemical structure of drug, design of drug formulation, etc.

    摘要翻译： 本发明提供了一种在体外预测食物 - 药物相互作用的方法，在口服给药的药物与胃肠道中的消化酶相互作用的情况下，通过测量药物对体外消化酶的活性，其基于 关于食物的摄取导致药物在体内的吸收由于药物和消化酶之间的上述相互作用而降低。 本发明还提供了通过减少消化酶的作用，例如引入前药，药物化学结构的改变，药物制剂的设计等，最小化摄入食物引起的体内吸收变化的方法。

    Preparing green phosphor based on zinc orthosilicate
    3.
    发明授权
    Preparing green phosphor based on zinc orthosilicate 失效
    基于原硅酸锌制备绿色荧光粉

    公开(公告)号：US06716369B1

    公开(公告)日：2004-04-06

    申请号：US09979314

    申请日：2002-02-20

    申请人： Ha-Kyun Jung ,  Bu Young Sung ,  Hee Dong Park

    发明人： Ha-Kyun Jung ,  Bu Young Sung ,  Hee Dong Park

    IPC分类号： C09K1154

    CPC分类号： C09K11/595 ,  C09K11/646

    摘要： This invention relates to a process for preparing a spherical green-emitting phosphor based on zinc orthosilicate and more particularly, to the process for a zinc orthosilicate-based green-emitting phosphor demonstrating an emission spectrum at visible regions, when excited by electron beam, via a new application of ‘the homogeneous precipitation method’ comprising the following steps such as i) a solution of tetraethylorthosilicate (TEOS) diluted in ethanol is hydrolyzed to obtain a hydrated silica, ii) said hydrated silica is dispersed together with the solution containing zinc and manganese components, iii) a precipitant selected from oxalic acid and oxalates is added to said dispersed solution together with a basic solution, while precipitating zinc and manganese components, iv) said admixture precipitate, so filtered off and dried, is calcined in the air and reheated under the reducing atmosphere to generate a phosphor powder; hence, the above-described phosphor particle is quite effective in a variety of display fields of industry including PDP, since it has a spherical shape with less agglomeration and homogeneous distribution of manganese, an activator, thus proving superior to the conventional phosphor prepared by the solid state reaction method in terms of brightness.

    摘要翻译： 本发明涉及一种制备基于原硅酸锌的球形绿色荧光体的方法，更具体地说，本发明涉及一种在电子束激发时通过可见光区域发射的基于原硅酸锌的绿色发光荧光体的发光光谱的方法， “均相沉淀法”的新应用包括以下步骤：i）将在乙醇中稀释的原硅酸四乙酯溶液（TEOS）水解，得到水合二氧化硅，ii）所述水合二氧化硅与含锌溶液和 锰组分，iii）将草酸和草酸盐的沉淀剂与碱性溶液一起加入到所述分散溶液中，同时沉淀锌和锰组分，iv）将所述混合物沉淀物滤出并干燥，在空气中煅烧， 在还原气氛下再加热，生成荧光粉; 因此，上述荧光体颗粒在包括PDP的工业的各种显示领域中是非常有效的，因为它具有较少的聚集和均匀分布的锰，活化剂的球形，因此证明优于由 固态反应方法在亮度方面。

    Strontium silicate-based phosphor, fabrication method thereof, and LED using the phosphor
    4.
    发明授权
    Strontium silicate-based phosphor, fabrication method thereof, and LED using the phosphor 有权
    硅酸锶系荧光体及其制造方法以及使用该荧光体的LED

    公开(公告)号：US07045826B2

    公开(公告)日：2006-05-16

    申请号：US10532094

    申请日：2004-03-26

    申请人： Chang Hae Kim ,  Joung Kyu Park ,  Hee Dong Park

    发明人： Chang Hae Kim ,  Joung Kyu Park ,  Hee Dong Park

    IPC分类号： H01L27/15

    CPC分类号： C09K11/7734 ,  H01L33/502

    摘要： A strontium silicate-based phosphor, a fabrication method thereof, and an LED using the strontium silicate-based phosphor are provided. The phosphor is applied to a long wavelength ultraviolet LED, an active luminous LCD, etc., to enable an improvement in the color purity and to enhance the luminous efficiency. The strontium silicate-based phosphor is expressed by a chemical formula: Sr3-xSiO5Eu2+x wherein x is 0

    摘要翻译： 提供了硅酸锶基荧光体及其制造方法以及使用硅酸锶系磷光体的LED。 将荧光体应用于长波长紫外线LED，有源发光LCD等，以提高色纯度并提高发光效率。 硅酸锶基荧光体由以下化学式表示：Sr 3-x SiO 2 O 2 O 2 + / / SO 2 >其中x是0