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公开(公告)号：US20080299109A1
公开(公告)日：2008-12-04
申请号：US12022510
申请日：2008-01-30
CPC分类号： G01N33/5058 , G01N2333/70571 , G01N2333/726
摘要： The present invention relates to a novel communication mechanism between astrocytes and neurons at a synapse. More specifically, the present invention relates to a signaling mechanism between astrocytes and neurons, by activating astrocytic G-protein coupled receptors, thereby activating glutamate receptors on a membrane of neighboring postsynaptic neurons, resulting in increasing the level of intracellular Ca2+ and inducing a depolarization inward current to control neurotransmission in neurons.
摘要翻译： 本发明涉及星形胶质细胞和突触间神经元之间的新型通讯机制。 更具体地说，本发明涉及星形胶质细胞和神经元之间的信号传导机制，通过激活星形细胞G蛋白偶联受体，从而激活相邻突触后神经元膜上的谷氨酸受体，导致细胞内Ca 2+的水平升高并引起向内的去极化 目前用于控制神经元中的神经传递。
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2.发明申请PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE AND METHOD OF SCREENING THE SAME 审中-公开用于预防或治疗变应性脑病的药物组合物及其筛选方法公开(公告)号：US20130046093A1
公开(公告)日：2013-02-21
申请号：US13588383
申请日：2012-08-17
申请人： Changjoon Justin LEE , Seonmi Jo , Boeun Yoon , Hyunah Choo , Ji Yoon Kim , Daesoo Kim
发明人： Changjoon Justin LEE , Seonmi Jo , Boeun Yoon , Hyunah Choo , Ji Yoon Kim , Daesoo Kim
IPC分类号： C07D498/04 , C07D513/04 , G01N33/53
CPC分类号： C07D498/04 , C07D513/04 , C12N2503/02 , G01N33/5058 , G01N33/6896 , G01N33/9426 , G01N2800/2814 , G01N2800/302
摘要： A pharmaceutical composition for preventing or treating a degenerative brain disease, and a method of screening a material for preventing or treating a degenerative brain disease. The method may effectively screen a prophylactic or therapeutic candidate material for preventing or treating a degenerative brain disease. A variety of degenerative brain diseases may be effectively prevented or treated using the pharmaceutical composition including a screened material for preventing or treating a degenerative brain disease.
摘要翻译： 用于预防或治疗退行性脑病的药物组合物，以及筛选用于预防或治疗退行性脑病的材料的方法。 该方法可以有效地筛选用于预防或治疗退行性脑病的预防性或治疗性候选物质。 可以使用包括用于预防或治疗退行性脑病的筛选材料的药物组合物来有效地预防或治疗各种退行性脑疾病。
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