公开(公告)号：US10548874B2

公开(公告)日：2020-02-04

申请号：US14200292

申请日：2014-03-07

申请人： Charite-Universitatsmedizin Berlin

发明人： Susanne Wagner ,  Matthias Taupitz ,  Eyk Schellenberger ,  Jorg Schnorr ,  Monika Ebert ,  Gesche Genter ,  Harald Kratz

IPC分类号： C01G49/02 ,  A61K9/51 ,  B82Y30/00 ,  C01G49/06 ,  A61K45/06 ,  A61K31/375 ,  A61K33/26 ,  A61K9/50

摘要： The present invention relates to a phosphate adsorbent on the basis of maghemite or maghemite/magnetite comprising (i) an iron oxide core comprising a crystal structure of inverse spinel iron oxide, (ii) a coating selected from monomeric carbohydrates, in particular monosaccharides or disaccharides, alditols, or mixtures thereof, and/or (iii) a pharmaceutical excipient selected from polymeric carbohydrates, wherein the phosphate adsorbent has the form of nanoparticles with a particle size of the iron oxide core (i) of less than 20 nm. The present invention further relates to a method for the production of a phosphate adsorbent on the basis of maghemite or maghemite/magnetite, to pharmaceutical compositions comprising the phosphate adsorbent, and to medical uses thereof, especially for the prevention and/or treatment of hyperphosphatemia.